[1]谭海鹏 高金峰 李琦玉 王樵梓 张宁 陈婧 黄浙勇.MicroRNA促进心肌细胞再生机制的研究进展[J].心血管病学进展,2020,(7):698-700.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.007]
 TAN Haipeng,GAO Jinfeng,LI Qiyu,et al.Mechanism of MicroRNA Promoting Cardiomyocyte Regeneration[J].Advances in Cardiovascular Diseases,2020,(7):698-700.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.007]
点击复制

MicroRNA促进心肌细胞再生机制的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年7期
页码:
698-700
栏目:
出版日期:
2020-07-25

文章信息/Info

Title:
Mechanism of MicroRNA Promoting Cardiomyocyte Regeneration
作者:
谭海鹏 高金峰 李琦玉 王樵梓 张宁 陈婧 黄浙勇
(上海市心血管病研究所 复旦大学附属中山医院心内科,上海 200032)
Author(s):
TAN HaipengGAO JinfengLI QiyuWANG QiaoziZHANG NingCHEN JinHUANG Zheyong
(Shanghai Institute of Cardiovascular Diseases,Department of Cardiology, Zhongshan Hospital, Fudan University,Shanghai 200032,China)
关键词:
急性心肌梗死心肌细胞再生MicroRNA机制Hippo信号通路
Keywords:
Acute myocardial infarctionCardiomyocyteRegenerationMicroRNAMechanismHippo pathway
DOI:
10.16806/j.cnki.issn.1004-3934.2020.07.007
摘要:
急性心肌梗死作为心血管系统最常见的急症之一,其在中国的发病率和死亡率呈逐年上升趋势。为了进一步改善心肌梗死患者预后,成年哺乳动物心肌细胞再生一直是心血管领域研究的热点之一。近年来,microRNA对心肌细胞再生的调控作用正受到越来越多关注,其外源类似物的应用有望成为改善心肌梗死患者预后的一种全新手段,但其作用机制尚不完全清楚。现围绕Hippo信号通路就近年来相关机制的研究进行综述,以探讨microRNA应用于改善心肌梗死患者预后的可能性。
Abstract:
Acute myocardial infarction is one of the most common emergencies of the cardiovascular system, and its morbidity and mortality are still increasing year by year in China. In order to further improve the prognosis of patients with myocardial infarction, the cardiomyocyte regeneration of adult mammalian has been one of the hot topics in the field of cardiovascular research. In recent years, the regulatory effect of microRNA on cardiomyocyte regeneration is getting more and more attention. The application of exogenous microRNA analogues is expected to become a potential method to improve the prognosis of patients with myocardial infarction. But the specific mechanism by which it works is not completely clear. This article reviews the potential mechanism around the Hippo signal pathway in recent years to explore the possibility of applying microRNA to improve the prognosis of patients with myocardial infarction

参考文献/References:

[1] 陈伟伟,高润霖,刘力生,等.《中国心血管病报告2016》概要[J].中国循环杂志,2017,32(6):521-530.

[2] Anderson JL,Morrow DA.Acute myocardial infa rction[J].N Engl J Med,2017,376(21): 2053-2064.

[3] Bergmann O,Bhardwaj RD,Bernard S,et al.Evidence for cardiomyocyte renewal in humans [J].Science,2009,324(5923):98-102.

[4] Senyo SE,Steinhauser ML,Pizzimenti CL,et al.Mammalian heart renewal by pre-existing cardiomyocytes[J].Nature,2013,493(7432):433-436.

[5] Porrello ER,Mahmoud AI,Simpson E,et al.Transient regenerative potential of the neonatal mouse heart[J].Science,2011,331(6020):1078-1080.

[6] Menasche P.Cell therapy trials for heart regeneration—lessons learned and future directions[J].Nat Rev Cardiol,2018,15(11):659-671.

[7] Li Y,He L,Huang X,et al.Genetic lineage tracing of nonmyocyte population by dual recombinases[J].Circulation,2018,138(8):793-805.

[8] Eschenhagen T,Bolli R,Braun T,et al.Cardiomyocyte regeneration: a consensus statement [J].Circulation,2017,136(7):680-686.

[9] Galdos FX,Guo Y,Paige SL,et al.Cardiac regeneration: lessons from development[J]. Circ Res,2017,120(6):941-959.

[10]Sayed D,Abdellatif M.MicroRNAs in development and disease[J].Physiol Rev,2011, 91(3):827-887.

[11] 马天雪,赵玉娟.长链非编码RNA及相关调控通路与急性心肌梗死的研究进展[J].心血管病学进展,2019,40(8):1099-1103.

[12]Hodgkinson CP,Kang MH,Dal-Pra S,et al.MicroRNAs and cardiac regen eration[J].Circ Res,2015,116(10):1700-1711.

[13] Eulalio A,Mano M,Dalferro M,et al.Functional screening identifies miRNAs inducing cardiac regeneration[J].Nature,2012,492(7429):376-381.

[14] Chen J,Huang ZP,Seok HY,et al.miR-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts[J].Circ Res,2013, 112(12):1557-1566.

[15]Tian Y,Liu Y,Wang T,et al.A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice[J].Sci Transl Med,2015,7(279): 279ra38.

[16]Lesizza P,Prosdocimo G,Martinelli V,et al.Single-dose intracardiac injection of pro-regenerative micr oRNAs improves cardiac function after myocardial infarction [J].Circ Res,2017,120(8):1298-1304.

[17]Kwon Y,Vinayagam A,Sun X,et al.The Hippo signaling pathway interactome[J].Science, 2013,342(6159):737-740.

[18]Flinn MA,Link BA,O’Meara CC.Upstream regulation of the Hippo-YAP pathway in cardiomyocyte regeneration[J].Semin Cell Dev Biol, 2020,100:11-19.

[19]Ardestani A,Lupse B,Maedler K.Hippo signaling: key emerging pathway in cellular and whole-body metabolism [J].Trends Endocrinol Metab,2018,29(7):492-509.

[20]von Gise A,Lin Z,Schlegelmilch K,et al.YAP1,the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy[J]. Proc Natl Acad Sci USA,2012,109(7):2394-2399.

[21]Lin Z,von Gise A,Zhou P,et al.Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model[J].Circ Res,2014,115(3): 354-363.

[22] Monroe TO,Hill MC,Morikawa Y,et al.YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in vivo[J].Dev Cell,2019, 48(6):765-779.e7.

[23] Leach JP,Heallen T,Zhang M,et al.Hippo pathway deficiency reverses systolic heart failure after infarction[J].Nature,2017,550(7675):260-264.

[24]Diez-Cunado M,Wei K,Bushway PJ,et al.miRNAs that induce human cardiomyocyte proliferation converge on the Hippo p athway[J].Cell Rep,2018,23(7):2168-2174.

[25] Torrini C,Cubero RJ,Dirkx E,et al.Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation[J].Cell Rep,2019,27(9): 2759-2771.e5.

[26] Zhao B,Li L,Tumaneng K,et al.A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)[J].Genes Dev,2010,24(1):72-85.

[27] Xie Y, Wang Q, Gao N, et al. MircroRNA-10b promotes human embryonic stem cell-derived cardiomyocyte proliferation via novel target gene LATS1 [J]. Mol Ther Nucleic Acids, 2019, 19:437-445.

[28] Dupont S,Morsut L,Aragona M,et al.Role of YAP/TAZ in mechanotransduction[J].Nature, 2011,474(7350):179-183.

[29]Chang L,Azzolin L,di Diagio D,et al.The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ[J].Nature,2018,563(7730):265-269.

[30]Lee JY,Dominguez AA,Nam S,et al.Identification of cell context-dependent YAP-associated proteins reveals beta1 and beta4 integrin mediate YAP translocation independently of cell spreading[J].Sci Rep,2019,9(1):17188.

[31] Lee J,Manoharan V,Cheung L,et al.Nanoparticle-based hybrid scaffolds for deciphering the role of multimodal cues in cardiac tissue engineering[J].ACS Nano, 2019,13(11):12525-12539.

[32] Judd J,Lovas J,Huang GN.Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes[J].Sci Rep,2019,9(1):18830.

[33]Li X,He X,Wang H,et al.Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration[J].Cardiovasc Res,2018,114(12):1642-1655.

[34] Deng S,Zhao Q,Zhen L,et al.Neonatal heart-en riched miR-708 promotes proliferation and stress resistance of cardiomyocytes in rodents[J].Theranostics,2017,7(7): 1953-1965.

[35]Borden A,Kurian J,Nickoloff E,et al.Transient introduction of miR-294 in the heart promotes cardiomyocyte cell cycle reentry after injury[J].Circ Res,2019,125(1): 14-25.

[36] Wang J,Chen X,Shen D,et al.A long noncoding RNA NR_045363 controls cardiomyocyte proliferation and cardiac repair[J].J Mol Cell Cardiol,2019,127:105-114.

[37]Trivedi CM,Zhu W,Wang Q,et al.Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation[J].Dev Cell,2010,19(3):450-459.

[38]Gabisonia K,Prosdocimo G,Aquaro GD,et al.MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs[J].Nature,2019,569(7756): 418-422.

[39] Ikeda S,Mizushima W,Sciarretta S,et al.Hippo deficiency leads to cardiac dysfunction accompanied by cardiomyocyte dedifferentiation during pressure overload[J].Circ Res,2019,124(2):292-305.

相似文献/References:

[1]林远龙,刘现亮.无复流现象:从基础到临床[J].心血管病学进展,2016,(1):53.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.014]
 LIN Yuanlong,LIU Xianliang.From Bench to Bed:No-reflow Phenomenon[J].Advances in Cardiovascular Diseases,2016,(7):53.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.014]
[2]赵劲东,综述,董平栓,等.合并多支血管病变的急性ST段抬高型心肌梗死介入术治疗策略的研究进展[J].心血管病学进展,2016,(3):295.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.021]
 ZHAO Jindong,DONG Pingshuan.Research Progress of Interventional Therapy in Patients with ST-elevation Myocardial Infarction and Multivessel Disease[J].Advances in Cardiovascular Diseases,2016,(7):295.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.021]
[3]余正春,综述,马小静,等.急性心肌梗死并发心源性休克的治疗进展[J].心血管病学进展,2016,(4):441.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.029]
 YU Zhengchun,MA Xiaojing.Treatment of Cardiogenic Shock Complicating Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2016,(7):441.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.029]
[4]袁帅,毛玉琳,钱志敏,等.经皮冠脉介入术在高龄老年患者治疗中的研究新进展[J].心血管病学进展,2019,(6):864.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.007]
 YUAN Shuai,MAO Yulin,QIAN Zhimin,et al.New Progress in Study of PCI in treatment of Elderly Patients[J].Advances in Cardiovascular Diseases,2019,(7):864.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.007]
[5]元洋洋 李波.Selvester QRS评分系统研究进展[J].心血管病学进展,2019,(7):985.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.005]
 YUAN YangyangLI Bo.Research Progress of Selvester QRS Scoring System[J].Advances in Cardiovascular Diseases,2019,(7):985.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.005]
[6]翁子骞 于波.血栓抽吸在急性ST段抬高型心肌梗死中的研究进展[J].心血管病学进展,2019,(7):1035.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.018]
 WENG ZiqianYU Bo.Thrombus aspiration in acute ST-segment elevation myocardial infarction[J].Advances in Cardiovascular Diseases,2019,(7):1035.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.018]
[7]林莉 韦铁民.急性心肌梗死后心脏破裂[J].心血管病学进展,2019,(7):1039.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.019]
 LIN LiWEI Tiemin.Post-infarction Cardiac Rupture[J].Advances in Cardiovascular Diseases,2019,(7):1039.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.019]
[8]黄淮滨 刘甲兴.肥厚型心肌病治疗新靶点——钙脱敏治疗[J].心血管病学进展,2019,(7):1047.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.021]
 HUANG HuaibinLIU Jiaxing.A Novel Target for Therapy in Hypertrophic Cardiomyopathy: Ca2+ desensitizer[J].Advances in Cardiovascular Diseases,2019,(7):1047.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.021]
[9]杨颜瑜,苏星,谭敏,等.炎症指标与急性心肌梗死研究进展[J].心血管病学进展,2019,(6):947.[doi:10.16806/j.cnki.issn.1004-3934.2019.0.027]
 YANG Yanyu,SU Xing,TAN Min,et al.Relationship Between Inflammation Index and Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(7):947.[doi:10.16806/j.cnki.issn.1004-3934.2019.0.027]
[10]崔小豪 杨志明.和肽素在急性心肌梗死中的研究进展[J].心血管病学进展,2019,(5):726.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.016]
 CUI Xiaohao,YANG Zhiming.Copeptin in Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(7):726.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.016]

更新日期/Last Update: 2020-10-09