[1]肖亚楠 高传玉 朱中玉.低剂量替格瑞洛在冠心病中的应用前景[J].心血管病学进展,2020,(7):706-709.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.009]
 XIAO Yanan,GAO Chuanyu,ZHU Zhongyu.Application Prospects of Low-dose Ticagrelor in Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2020,(7):706-709.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.009]
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低剂量替格瑞洛在冠心病中的应用前景()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年7期
页码:
706-709
栏目:
出版日期:
2020-07-25

文章信息/Info

Title:
Application Prospects of Low-dose Ticagrelor in Coronary Heart Disease
作者:
肖亚楠 高传玉 朱中玉
(郑州大学人民医院 河南省人民医院心脏中心,河南 郑州 450003)
Author(s):
XIAO Yanan GAO Chuanyu ZHU Zhongyu
(Peoples Hospital of Zhengzhou University, Heart Center of Henan Provincial Peoples Hospital,Zhengzhou 450003,Henan,China)
关键词:
替格瑞洛低剂量冠状动脉粥样硬化性心脏病
Keywords:
TicagrelorLow-doseCoronary atherosclerotic heart disease
DOI:
10.16806/j.cnki.issn.1004-3934.2020.07.009
摘要:
血小板聚集所致的急性血栓形成是急性冠脉综合征发病的重要机制,在高缺血风险的慢性冠心病患者中也存在血小板过度激活。因此,抗血小板治疗是冠状动脉粥样硬化疾病治疗的基石。PEGASUS-TIMI 54研究首次证明与标准剂量相比,低剂量的替格瑞洛同样可降低缺血事件,且不良反应发生率较低。自此,国内外开展了一些针对低剂量替格瑞洛在冠心病患者中的疗效与安全性的研究。现对低剂量替格瑞洛的临床药理学特点、循证医学证据及临床应用前景进行综述。 【
Abstract:
Acute thrombosis induced by platelet aggregation is an important mechanism of acute coronary syndrome, and there is excessive activation of platelet in patients with chronic coronary heart disease with high ischemic risk. Therefore, antiplatelet therapy is the cornerstone of the treatment of coronary atherosclerotic diseases. PEGASUS-TIMI 54 showed for the first time that a lower dose of ticagrelor can also reduced ischemic events compared to standard doses, and the incidence of adverse events was lower. Since then, some studies on the efficacy and safety of low-dose ticagrelor in patients with coronary heart disease have been carried out at home and abroad. This article will review the clinical pharmacology features, evidence-based medical evidence and clinical application prospects of low-dose ticagrelor.

参考文献/References:

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更新日期/Last Update: 2020-10-09