[1]汪羚利 李昭屏.盐皮质激素受体拮抗剂在难治性高血压中的应用现状[J].心血管病学进展,2020,(10):1026.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.007]
 WANG Lingli,LI Zhaoping.Application Status of Mineralocorticoid-receptor Antagonists in Resistant Hypertension[J].Advances in Cardiovascular Diseases,2020,(10):1026.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.007]
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盐皮质激素受体拮抗剂在难治性高血压中的应用现状()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年10期
页码:
1026
栏目:
综述
出版日期:
2020-10-25

文章信息/Info

Title:
Application Status of Mineralocorticoid-receptor Antagonists in Resistant Hypertension
作者:
汪羚利 李昭屏
(北京大学第三医院心内科,血管医学研究所,卫生部心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京 100191)
Author(s):
WANG LingliLI Zhaoping
(1.Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Ministry of Health; Key Laboratory of Molecular Cardiovascular Science,Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research ,Beijing 100191 ,China)
关键词:
难治性高血压 盐皮质激素受体拮抗剂螺内酯依普利酮
Keywords:
Resistant hypertensionMineralocorticoid-receptor antagonistsSpironolactoneEplerenone
DOI:
10.16806/j.cnki.issn.1004-3934.2020.10.007
摘要:
难治性高血压在临床上并不少见,其发生发展过程机制复杂,其中肾素-血管紧张素-醛固酮系统起重要作用。醛固酮是肾素-血管紧张素-醛固酮系统中的关键激素,对醛固酮具有拮抗作用的盐皮质激素受体拮抗剂是治疗难治性高血压的最佳药物选择之一。现主要对盐皮质激素受体拮抗剂在难治性高血压中的作用机制、相关临床研究及不良反应进行总结,以便临床医生更规范地使用该类药物。
Abstract:
Resistant hypertension (RHTN) is not uncommon in clinical practice. Among the complicated development mechanism of RHTN ,renin-angiotensin-aldosterone system(RAAS) play an important role. Aldosterone is a key pivotal hormone in RAAS,as a result,mineralocorticoid-receptor antagonist (MRAs),which has an antagonistic effect on aldosterone,is one of the best choice for treatment of RHTN. This review will summarize the mechanism,clinical studies and adverse reactions of MRAs in RHTN,and help physicians make better use of MRAs

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更新日期/Last Update: 2020-12-21