[1]韩月 朱莉 宋桂仙.白介素-12家族在冠状动脉粥样硬化中的研究进展[J].心血管病学进展,2020,(5):508-512.[doi:10.16806/j.cnki.issn.1004-3934.20.05.016]
 HAN Yue,ZHU Li,SONG Guixian.Interleukin-12 Family in Coronary Atherosclerosis[J].Advances in Cardiovascular Diseases,2020,(5):508-512.[doi:10.16806/j.cnki.issn.1004-3934.20.05.016]
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白介素-12家族在冠状动脉粥样硬化中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年5期
页码:
508-512
栏目:
出版日期:
2020-05-25

文章信息/Info

Title:
Interleukin-12 Family in Coronary Atherosclerosis
作者:
韩月1 朱莉 2 宋桂仙2
(1.扬州大学医学院,江苏 扬州225000;2.泰州市人民医院心内科,江苏 泰州225300)
Author(s):
HAN Yue1 ZHU Li2 SONG Guixian2
(1.Yangzhou University,Yangzhou 226000,Jiangsu,China;2.Department of Taizhou Hospital,Taizhou 225300,Jiangsu,China)
关键词:
白介素-12家族冠状动脉粥样硬化细胞因子炎症
Keywords:
Interleukin-12 family Coronary atherosclerotic CytokinesInflammation
DOI:
10.16806/j.cnki.issn.1004-3934.20.05.016
摘要:
近年来研究发现炎症的持续和免疫应答失衡在动脉粥样硬化的发生和发展中起到关键作用。多种炎症细胞其分泌的细胞因子参到冠状动脉粥样硬化的过程中。而-12家族作为重要的炎症细胞因子,其家族成员包括IL-12、IL-23、IL-27、IL-35、IL-39和IL-Y,在冠心病的疾病过程中产生的促进或抑制作用已成为近年来国内外心血管领域的研究热点。主要阐述-12家族各细胞因子对冠状动脉粥样硬化作用的研究现状,可能为冠心病的病情评估和治疗提供新的思路。
Abstract:
In recent years,the persistence of inflammation and the imbalance of immune response have been found to play a key role in the occurrence and development of atherosclerosis.Many inflammatory cells and their secreted cytokines are involved in the process of coronary atherosclerosis.Interleukin(IL)-12 family is as inflammatory cell factor,and the family members include IL-12,IL-23,IL-27,IL-35,IL-39 and IL-Y. The promoting or inhibiting effect produced in the process of coronary heart disease has been a hotspot in the cardiovascular research field in recent years.This article mainly describes the current understanding of the role of IL-12 family cytokines in coronary atherosclerosis,which may provide new ideas for the evaluation and treatment of coronary heart disease

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备注/Memo

备注/Memo:
收稿日期:2019-10-09基金项目:国家自然科学基金(81600223)
更新日期/Last Update: 2020-08-12