[1]王辉 蒋永兴 田野.下肢动脉硬化闭塞症:炎症机制与抗炎治疗的研究进展[J].心血管病学进展,2020,(2):179-182.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.020]
 WANG HuiJIANG YongxingTIAN Ye.Peripheral Arterial DiseaseA Research Progress Review of Inflammatory Mechanism and Anti-inflammatory Therapy[J].Advances in Cardiovascular Diseases,2020,(2):179-182.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.020]
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下肢动脉硬化闭塞症:炎症机制与抗炎治疗的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年2期
页码:
179-182
栏目:
综述
出版日期:
2020-02-25

文章信息/Info

Title:
Peripheral Arterial DiseaseA Research Progress Review of Inflammatory Mechanism and Anti-inflammatory Therapy
作者:
王辉 蒋永兴 田野
(哈尔滨医科大学第一附属医院心内科,黑龙江 哈尔滨 150000 )
Author(s):
WANG HuiJIANG YongxingTIAN Ye
(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150000 ,Heilongjiang,China)
关键词:
下肢动脉硬化闭塞症炎症抗炎治疗声动力疗法
Keywords:
Peripheral arterial disease Inflammation Anti-inflammatory treatment Sonodynamic therapy
DOI:
10.16806/j.cnki.issn.1004-3934.2020.02.020
摘要:
下肢动脉硬化闭塞症(peripheral arterial disease,PAD)是由于下肢动脉管腔狭窄或闭塞,而引起患者间歇性跛行与静息痛的一种动脉粥样硬化性疾病。其发病率在世界范围内逐年增高,可导致心血管事件高发。现综述动脉粥样硬化炎症在PAD发生发展过程中的作用,讨论有间歇性跛行症状的PAD患者的介入治疗及抗炎治疗的效果。最后,展望探讨了一种新的治疗方式,即声动力疗法,通过靶向清除动脉粥样硬化斑块内巨噬细胞来减轻动脉炎症反应,从而改善PAD患者的跛行症状。
Abstract:
Peripheral arterial disease (PAD) is an atherosclerotic disease caused by intermittent claudication and rest pain of patients due to stenosis or occlusion of arterial lumen of lower limbs. Worldwide, its incidence is increasing year by year, involving a large number of patients, and can lead to a high incidence of cardiovascular events. This article reviews the role of atherosclerotic inflammation in the development of PAD and discusses the efficacy of interventional therapy and anti-inflammatory therapy in PAD patients with intermittent claudication. Additionally, we introduce a novel approach, sonodynamic therapy,which can alleviate arterial inflammation by targeted removing macrophages in atherosclerotic plaques, thereby improving claudication in PAD patients

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更新日期/Last Update: 2020-04-14