[1]罗芩 何庆.TNF凝集素样结构域：高原肺水肿药物治疗新选择罗芩 何庆2[J].心血管病学进展,2019,(9):1301-1304.[doi:10.16806/j.cnki.issn.1004-3934.2019.00.030]
　LUO QinHE Qing.The Lectin-like Domain of TNF:New Drug Treatment Option for HAPE[J].Advances in Cardiovascular Diseases,2019,(9):1301-1304.[doi:10.16806/j.cnki.issn.1004-3934.2019.00.030]
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TNF凝集素样结构域：高原肺水肿药物治疗新选择罗芩 何庆2()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1301-1304
栏目:
综述
出版日期:
2019-12-25

文章信息/Info

Title:
The Lectin-like Domain of TNF:New Drug Treatment Option for HAPE
作者:
罗芩1 何庆2
( 1．西南交通大学医学院,四川 成都 610036 ;2．西南交通大学医学院 西南交通大学附属医院 成都市第三人民医院,四川 成都 610036)
Author(s):
LUO Qin1HE Qing2
(1. Southwest Jiaotong University College of Medcine, Chengdu 610036, Sichuan, China;2.Southwest Jiaotong University College of Medcine, The Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu 610036, Sichuan, China)
关键词:
高原肺水肿; TNF凝集素样结构域; 药物治疗
Keywords:
High altitude pulmonary edema; The lectin-like domain of TNF; Pharmacotherapy
DOI:
10.16806/j.cnki.issn.1004-3934.2019.00.030
摘要:
高原肺水肿是高原地区人群常见的高原疾病之一，严重威胁着人们的生命健康。它的发病机制目前尚未完全清楚，主要与驱动水进入肺泡的力量和清除肺泡液的能力两者失衡有关。目前用于治疗高原肺水肿的药物大多作用机制不明且不良反应较多。而TNF凝集素样结构域一方面能直接激活Ⅱ型肺泡上皮顶端钠通道，加速水肿肺的肺泡液清除；另一方面还具有抗炎作用，能减慢肺水肿的形成，是高原肺水肿药物治疗的一种新选择。
Abstract:
High altitude pulmonary edema is one of the common diseases in high altitude area, which seriously threatens people’s life and health. Its pathogenesis is still not fully understood and is related to an imbalance between the force that drives water into the alveoli and the ability to clear alveolar fluid. At present, most drugs used to treat high altitude pulmonary edema have an unclear mechanism of action and many adverse reactions. The lectin-like domain of TNF on the one hand can directly activate type Ⅱ alveolar epithelial sodium channel to accelerate the clearance of alveolar fluid; and on the other hand, it has anti-inflammatory effect and can slow down the formation of pulmonary edema. So, the lectin-like domain of TNF is a new option for the pharmacotherapy of high-altitude pulmonary edema

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更新日期/Last Update: 2020-02-06