[1]孙静美 尹德春 曲秀芬.炎症信号与心房颤动[J].心血管病学进展,2020,(1):31-34.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.009]
 SUN Jingmei,YIN Dechun,QU Xiufen.Inflammatory Signals Associated with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2020,(1):31-34.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.009]
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炎症信号与心房颤动()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年1期
页码:
31-34
栏目:
综述
出版日期:
2020-02-04

文章信息/Info

Title:
Inflammatory Signals Associated with Atrial Fibrillation
作者:
孙静美 尹德春 曲秀芬
(哈尔滨医科大学附属第一临床医学院心内科,黑龙江 哈尔滨 150000)
Author(s):
SUN Jingmei YIN Dechun QU Xiufen
(Department of Cardiology,The First Affiliated Clinical Medical College of Harbin Medical University,Harbin 150000,Heilongjiang,China)
关键词:
心血管病学炎症因子心房颤动危险因素干预及治疗
Keywords:
Cardiovascular diseasesInflammatory cytokinesAtrial fibrillationRisk factorsIntervention and treatment
DOI:
10.16806/j.cnki.issn.1004-3934.2020.01.009
摘要:
心房颤动是病理生理学机制复杂的一种心律失常。大量的实验和临床资料表明,心房重构的病理生理学与炎症密切相关。心房重构和炎症之间的联系机制是复杂的,而不同的潜在疾病和条件均可能影响这些通路。炎症标志物与的发生发展以及射频消融术后复发有关。但最常用的抗炎药,如糖皮质激素,增加了感染、出血和高血糖的风险。另外抑制的治疗方法,如细胞因子,又严重干扰正常的心肌功能,在这种情况下,开发特定的抗炎干预措施似乎更具有挑战性和复杂性。这篇综述简要概述了心房颤动与C反应蛋白、肿瘤坏死因子α、转化生长因子、白介素-6、白介素-10、白介素-37之间的相关性以及探讨可能用于通过减轻炎症反应预防或治疗的药物、减少的危险因素、改变生活方式等方法作为上游治疗思路。
Abstract:
Atrial fibrillation is a kind of arrhythmia with complex pathophysiological mechanism.A large number of experimental and clinical data show that the pathophysiology of atrial remodeling is closely related to inflammation.The mechanism of association between atrial remodeling and inflammation is complex,and different underlying diseases and conditions may affect these pathways.Inflammatory markers are associated with the development of atrial fibrillation and recurrence after radiofrequency catheter ablation.But the most commonly used anti-inflammatory drugs,such as glucocorticoids,increase the risk of infection,bleeding and high blood sugar.In addition,inhibitory therapies,such as cytokines,severely interfere with normal cardiac function,in which case the development of specific anti-inflammatory interventions seems to be more challenging and complex.This review provides a brief overview of the association between atrial fibrillation and C-reactive protein,tumor necrosis factor-α,transforming growth factor,interleukin-6,interleukin-10 and interleukin-37.This review also explores the drugs that may be used to prevent or treat atrial fibrillation by reducing inflammatory response,reducing risk factors of atrial fibrillation,changing lifestyle and other methods as upstream treatment ideas.

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备注/Memo

备注/Memo:
通讯作者:曲秀芬,E-mail:hydxxg@sina.com
更新日期/Last Update: 2020-03-23