[1]孙洋.基质金属蛋白酶与心肌梗死后心脏重构[J].心血管病学进展,2019,(8):1094-1098.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.006]
 SUN Yang.Matrix Metalloproteinases in Cardiac Remodeling after Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(8):1094-1098.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.006]
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基质金属蛋白酶与心肌梗死后心脏重构()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年8期
页码:
1094-1098
栏目:
综述
出版日期:
2019-11-25

文章信息/Info

Title:
Matrix Metalloproteinases in Cardiac Remodeling after Myocardial Infarction
作者:
孙洋
(国家心血管病中心 中国医学科学院阜外医院实验诊断中心,北京 100037)
Author(s):
SUN Yang
(Diagnostic Laboratory Service, Fuwai Hospital, National Center for Cardiovascular Disease, Beijing 100037, China)
关键词:
基质金属蛋白酶心肌梗死心脏重构
Keywords:
Matrix metalloproteinases Myocardial infarction Cardiac remodeling
DOI:
10.16806/j.cnki.issn.1004-3934.2019.08.006
摘要:
心肌梗死后心脏重构与心力衰竭、心律失常密切相关,影响患者预后。基质金属蛋白酶作为细胞外基质成分的重要调节因子,在心肌梗死后心脏重构过程中发挥重要作用。现通过综述心肌梗死后心脏重构过程中各种基质金属蛋白酶表达量的改变、检测方法和针对基质金属蛋白酶的治疗现状,探讨基质金属蛋白酶作为心肌梗死或心力衰竭生物标志物的有效性,以及作为治疗靶点的前景。
Abstract:
Cardiac remodeling after myocardial infarction is closely related to heart failure and arrhythmia,and affects the prognosis of patients. Matrix metalloproteinase(MMPs) is an important regulator of extracellular matrix components and plays an important role in cardiac remodeling after myocardial infarction. To investigate the efficacy of MMPs as biomarkers for myocardial infarction or heart failure and its prospect as therapeutic targets ,the expression changes, detection methods and treatment status of MMPs in the process of cardiac remodeling after myocardial infarction were reviewed in this article .

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更新日期/Last Update: 2020-01-19