[1]晏露 李欣 柳志红.不同生物标志物在急性肺血栓栓塞症中的应用价值[J].心血管病学进展,2019,(5):687-692.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.007]
 YAN Lu,LI Xin,LIU Zhihong.The unction of Different Biomarkers in Acute Pulmonary Embolism[J].Advances in Cardiovascular Diseases,2019,(5):687-692.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.007]
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不同生物标志物在急性肺血栓栓塞症中的应用价值()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年5期
页码:
687-692
栏目:
综述
出版日期:
2019-08-25

文章信息/Info

Title:
The unction of Different Biomarkers in Acute Pulmonary Embolism
作者:
晏露 李欣 柳志红
(北京协和医学院 中国医学科学院 国家心血管病中心 阜外医院 肺血管病诊治中心,北京 100037)
Author(s):
YAN Lu LI Xin LIU Zhihong
(Center for ulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing100037,China)
关键词:
急性肺血栓栓塞症生物标志物
Keywords:
cute pulmonary embolism Biomarkers
DOI:
10.16806/j.cnki.issn.1004-3934.2019.05.007
摘要:
急性肺血栓栓塞症是临床上的急危重症,其症状多为胸痛呼吸困难晕厥等,易与其他心血管急症相混淆,在急诊室如何快速诊断并评估患者危险分层以指导临床治疗尤为重要,而其中生物标志物的作用越来越受到重视。目前最常用的生物标志物D-二聚体脑钠肽肌钙蛋白。此外,近年研究发现脂肪酸结合蛋白microRNA也有助于肺栓塞的危险分层和评估预后。一些炎症指标也有助于肺栓塞的预后评估。随着可用于监测的生物标志物的增加,如何合理选用生物标志物并正确分析其内涵尚缺乏系统性的认识。主要对生物标志物在急性肺血栓栓塞症的诊断、危险分层、预后评估等方面的作用进行综述。
Abstract:
Acute pulmonary embolism is a life-threatening disease in the emergency setting, which often presents with chest pain, dyspnea and syncope. Early diagnosis and accurate risk stratification is of great importance under such circumstance. Nowadays, more and more importance is attached to biomarkers. The most commomly used biomarkers are D-Dimer, BNP and troponin. Besides,the heart-type fatty acid-binding protein and microRNA also emerge as helpful biomarkers for risk stratification and prognostic assessment. Many inflammatory factor can also be used for prognosis. With the rapid development of biomarkers, how to choose laboratory examination rationally and interpretate them correctly remain difficult for clinicians. This article aimed to summarize the function of different biomarkers on diagnosis, risk stratification, prognostic assessment for patients suffering from acute pulmonary embolism. ?

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备注/Memo

备注/Memo:
基金项目:(2016YFC0905602)收稿日期:2019-02-15
更新日期/Last Update: 2019-12-23