[1]吴琼,杨爱玲,周端,等.扩张型心肌病左室逆重构的研究进展[J].心血管病学进展,2019,(6):885-889.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.012]
 WU Qiong,YANG Ailing,ZHOU Duan,et al.Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy[J].Advances in Cardiovascular Diseases,2019,(6):885-889.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.012]
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年6期
页码:
885-889
栏目:
综述
出版日期:
2019-09-25

文章信息/Info

Title:
Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy
作者:
吴琼 杨爱玲 周端 王佑华
(上海中医药大学附属龙华医院,上海 200032)
Author(s):
WU QiongYANG AilingZHOU DuanWANG Youhua
(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
关键词:
扩张型心肌病左室逆重构预测因子
Keywords:
Dilated cardiomyopathy Left ventricular inverse reconstructionPredictive factors
DOI:
10.16806/j.cnki.issn.1004-3934.2019.06.012
摘要:
药物或器械治疗能使心力衰竭患者左心室容积和质量发生不同程度的降低,部分心室甚至恢复至正常形态大小,这种生物学改变称为“左室逆重构”。如今左室逆重构是否出现已被认为是评价扩张型心肌病治疗是否有效以及评估其预后的重要依据,然现关于扩张型心肌病左室逆重构的认识还不够充分。本文围绕逆重构的意义、与扩张型心肌病病因及心功能的关系,临床预测因子等方面,就扩张型心肌病左室逆重构研究进展进行综述。
Abstract:
Treatment in drug or instrument can reduce the volume and quality of the left ventricle of patients with heart failure to varying degrees, and some ventricles even return to normal shape and size. This biological change is called "left ventricular reverse remodeling".Nowadays, the occurrence of left ventricular inverse remodeling has been considered as an important basis for the evaluation of the effectiveness of the treatment of dilated cardiomyopathy and the prognosis of dilated cardiomyopathy. However, the understanding of left ventricular inverse remodeling in dilated cardiomyopathy is still insufficient.This article reviews the progress of left ventricular inverse remodeling in dilated cardiomyopathy in terms of its significance, relationship with etiology and function of dilated cardiomyopathy, and clinical predictors.

参考文献/References:

[1]胡奕然.心脏逆重构的研究进展[J].中国循环杂志,2017,32(7):714-716.

[2]?Mann DL, Barger PM, Burkhoff D. Myocardial recovery and the failingheart[J].J Am Coll Cardiol,2012,60(24):2465-2472.

[3]MerloM,PivettaA,PinamontiB,et al.Long-term prognostic impact of therapeutic strategies in patients withidiopathic dilated cardiomyopathy:changing mortality over the last 30 years[J].EurJ Heart Fail,2014,16(3):317-324.

[4]MerloM, GobboM, StolfoD, et al.The prognostic impact ofthe evolution of RV function in idiopathic DCM[J].?JACC Cardiovasc?Imaging,2016,9(9):1034-1042.

[5]?Matsumura Y,Hoshikawa-Nagai E,Kubo T,et al.?Left ventricular reverse remodeling in long-term (>12 years)survivors with idiopathic dilated cardiomyopathy[J].Am JCardiol,2013,111(1):106-110.

[6]Merlo M,Stolfo D,Anzini M,et al. Persistent recoveryof normal left ventricular function and dimension in idiopathicdilated cardiomyopathy during long-term followup:does real healing exist??[J].J?Am Heart Assoc,2015,4(14):e001504.

[7]Hoshikawa?E, Matsumura?Y,KuboT, et al.Effect of left ventricular reverse remodeling on long-term prognosisafter therapywith angiotensin-converting enzyme inhibitors or angiotensin II receptorblockers and beta blockers in patients with idiopathic dilated cardiomyopathy?[J].Am J Cardiol,2011,107(7):1065-1070.

[8]AdamoL,PerryA,NovakE,et al.?Abnormal globallongitudinal strain predicts future deterioration of left ventricular function inheart failure patients with a recovered left ventricular ejection fraction[J].Circ HeartFail,2017,10(6):e003788.

[9]Merlo M,Pyxaras SA,Pinamonti B,et al. Prevalence andprognostic significance of left ventricular reverse remodelingin dilated cardiomyopathy receiving tailored medicaltreatment[J].J Am Coll Cardiol,2011,57(13):1468-1476.

[10]王世鹏,徐俊波,胡咏梅,.?扩张型心肌病研究进展[J].心血管病学进展,2017,38:229-232.

[11]Zecchin?M, Proclemer?A,Magnani?S,et al.?Long-term outcome of “superresponder”patients to cardiac resynchronization therapy[J].?Europace,2014,16(3):363-371.

[12]Jansweijer JA,Nieuwhof K,Russo F,et al. Truncatingtitin mutations are associated with a mild and treatableform of dilated cardiomyopathy[J].?Eur J Heart Fail,2017,19(4):512-521.

[13]Felkin LE,Walsh R,Ware JS,et al. Recovery of cardiacfunction in cardiomyopathy caused by titin truncation[J].JAMA Cardiol,2016,1(2):234-235.

[14]Ponikowski P,?Voors AA,?Anker SD,et al.?2016 ESC guidelines for the diagnosis andtreatment of acute and chronic heart failure[J].?Eur Heart J,2016,37(27):2129-2200.

[15]MannDL,BargerPM,BurkhoffD.Myocardial recovery and the failing heart:myth,magic, or molecular target?[J].J AmCollCardiol,2012,60(24):2465-2472.

[16]中华医学会心血管病学分会,中国心肌炎心肌病协作组.中国扩张型心肌病诊断和治疗指南[J].临床心血管病杂志,2018,34(5):421-434.

[17]Nerheim P, Birger-Botkin S, Piracha L, et al. Heart failureand sudden death in patients with tachycardia-inducedcardiomyopathy and recurrent tachycardia[J].Circulation,2004,110(3):247-252

[18]Mann DL,Barger PM,Burkhoff D. Myocardialrecovery and the failing heart:myth,magic,or moleculartarget?[J].J Am Coll Cardiol,2012,60(24):2465-2472.

[19]Miles C,?Finocchiaro G,?Papadakis M,et al. Sudden death and left ventricular involvement in arrhythmogenic cardiomyopathy[J].Circulation,2019,10(3):e037230.

[20]Ewer MS,Vooletich MT,Durand JB,et al. Reversibilityof trastuzumab-related cardiotoxicity: new insights basedon clinical course and response to medical treatment[J].J Clin Oncol,2005,23(31):7820-7826.

[21]McNamara DM,Elkayam U,Alharethi R,et al. Clinicaloutcomes for peripartum cardiomyopathy in NorthAmerica: Results of the IPAC Study(Investigations of Pregnancy-Associated Cardiomyopathy)[J].?J Am CollCardiol,2015,66(8):905-914.

[22]Anzini?M,Merlo?M,Sabbadini?G,et al.?Long-term evolutionand prognostic stratification of biopsy-proven active myocarditis[J].Circulation,2013,128(22):2384-2394.

[23]McNamara DM,Starling RC,Cooper LT,et al. Clinicaland demographic predictors of outcomes in recent onsetdilated cardiomyopathy: Results of the IMAC(Intervention in Myocarditis and AcuteCardiomyopathy)-2 study[J].J Am Coll Cardiol,2011,58(11):1112-1118.

[24]巫雪飞,黄燕,房晓楠,.扩张型心肌病患者经标准药物治疗后左心室射血分数恢复正常的发生率及预测因素分析[J].中国循环杂志,2015,30(5):417-421.

[25]Ponikowski P,Voors AA,Anker SD,et al. 2016 ESC guidelines for the diagnosis and

treatment of acute and chronic heart failure[J].Eur Heart J,2016,37(27):2129-2200.

[26]Becker MAJ,?Cornel JH,?van de Ven PM,et al.The Prognostic value of late gadolinium-enhanced cardiac magnetic resonance imaging in nonischemic dilated cardiomyopathy[J]. JACC Cardiovasc Imaging,2018,11(9):1274-1284.

[27]Kubanek M,Sramko M,Maluskova J,et al. Novel predictorsof left ventricular reverse remodeling in individualswith recent-onset dilated cardiomyopathy[J].J Am CollCardiol,2013,61(1):54-63.

[28]Leong DP,Chakrabarty A,Shipp N,et al. Effects ofmyocardial fibrosis and ventricular dyssynchronyonresponse to therapy in new-presentation idiopathic dilatedcardiomyopathy:?insights from cardiovascular magneticresonance and echocardiography[J].Eur Heart J,2012,33(5):640-648.

[29]Amorim S,Campelo M,Martins E,et al. Prevalence,predictors and prognosis of ventricular reverse remodelingin idiopathic dilated cardiomyopathy[J].?Rev PortCardiol,2016,35(5):253-260.

[30]Broch K,Murbraech K,Andreassen AK,et al.Contemporary outcome in patients with idiopathicdilated cardiomyopathy[J].AmJCardiol,2015,116(6):952-959.

[31]Hoit BD. The Pythian left atrium:predicting LV reverseremodeling and cardiovascular events in new-onset dilatedcardiomyopathy[J].J Card Fail,2016,22(4):280-282.

[32]Moon J,Shim CY,Kim YJ,et al. Left atrial volume as apredictor of left ventricular functional recovery inpatients with dilated cardiomyopathy and absence ofdelayed enhancement in cardiac magnetic resonance[J].J Card Fail,2016,22(4):265-271.

[33]Ikeda Y,Inomata T,Fujita T,et al. Cardiac fibrosisdetected by magnetic resonance imaging on predictingtime course diversity of left ventricular reverse remodelingin patients with idiopathic dilated cardiomyopathy[J].Heart Vessels,2016,31(11):1817-1825.

[34]Merlo?M, Gobbo?M,Stolfo?D,?et al.?The prognostic impact ofthe evolution of RV function in idiopathic DCM[J].JACC Cardiovasc Imaging,2016,9(9):1034-1042.

[35]Stolfo?D,Merlo?M, Pinamonti?B,?et al.?Early improvement of functional mitral regurgitation in patients withidiopathic dilated cardiomyopathy[J].?Am J Cardiol,2015,115(8):1137-1143

[36]Ahmad?F, SeidmanJG,SeidmanCE.The genetic basis for cardiac remodeling[J].Annu Rev Genomics Hum Genet,2005,6(1):185-216.

[37]Dal Ferro?M, Stolfo?D,Altinier?A,?et al.?Association betweenmutation status and left ventricular reverse remodelling in dilated cardiomyopathy[J].Heart,2017,103(21):1704-1710.

[38]Rossi?A, Dini?FL,Faggiano?P,?et al.?Independent prognosticvalue of functional mitral regurgitation in patients with heart failure. A quantitativeanalysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopath[J].Heart,2011,97(20):1675-1680.

[39]Merlo?M,PyxarasSA,Pinamonti?B,et al.?Prevalenceand prognostic significance ofleft ventricular reverse remodeling in dilated cardiomyopathyreceiving tailored medical treatment[J].J AmColl Cardiol,2011,57(13):1468-1476.

[40]Aleksova?A, Carriere?C, Zecchin?M,?et al.?New-onset left bundle branch block independently predicts long-term mortalityin patients with idiopathic dilated cardiomyopathy:data from the TriesteHeartMuscleDisease Registry[J].?Europace,2014,16(10):1450-1459.

[41]Aleksova?A, Merlo?M,Zecchin?M,?et al.?Impact of atrial fibrillation on outcome of patientswith idiopathic dilatedcardiomyopathy:data from the Heart Muscle Disease Registry of Trieste[J].?Clin MedRes,2010,8(3-4):142-149.


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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81328025、81873264);上海市科委科研计划项目(17401901600)
通讯作者:王佑华,E-mail:doctorwyh@163.com
更新日期/Last Update: 2019-12-11