[1]王宏宇.肥胖相关的代谢综合征及其心脏和血管损伤[J].心血管病学进展,2016,(4):331-333.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.001]
　WANG Hongyu.Obesity-Related Metabolic Syndrome and Its Heart and Vascular Damage[J].Advances in Cardiovascular Diseases,2016,(4):331-333.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.001]
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肥胖相关的代谢综合征及其心脏和血管损伤()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
331-333
栏目:
主题综述
出版日期:
2016-08-15

文章信息/Info

Title:
Obesity-Related Metabolic Syndrome and Its Heart and Vascular Damage
作者:
王宏宇
北京大学首钢医院血管医学中心 北京大学医学部血管疾病社区防治中心 北大医疗心脏和血管健康管理中心,北京 100144
Author(s):
WANG Hongyu
Centre of Vascular Medicine,Peking University Shougang Hospital,Beijing 100144,China
关键词:
肥胖;  交感神经系统;  代谢综合征;  血管损伤
Keywords:
Obesity;  Sympathetic nervous system;  Metabolic syndrome;  Vascular damage
分类号:
R54; R589.2
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.001
文献标志码:
A
摘要:
代谢综合征近年的发病率在全球范围内明显增加。交感神经系统过度激活是代谢综合征患者发生高血压及其相关心脏和血管损伤的基本机制。交感神经活性的激活可通过动脉压力感受器受损激发,也可通过一些代谢异常的通道激活。长期交感神经系统过度激活致胰岛素敏感性下降并形成一个恶性循环,最终引发高血压和代谢综合征,并产生心脏、血管和肾脏疾病。选择性肾脏消融术是近期出现的临床用于控制肥胖相关高血压的新技术。现综述交感神经过度激活与代谢综合征的关系,以及其继发性心脏和血管损害。
Abstract:
The prevalence of metabolic syndrome has increased worldwide over the past several years.Sympathetic nervous system overactivity is a key mechanism leading to hypertension and its related heart and vascular damage in patients with metabolic syndrome.Sympathetic activation can be triggered by reflex mechanisms as arterial baroreceptor impairment,by metabolic factors as insulin resistance,and by dysregulated adipokine production and secretion from the visceral fat with a mainly permissive role of leptin and antagonist role of adiponectin.Chronic sympathetic nervous system overactivity contributes to a further vicious circle that may contructure to the development of hypertension and of the metabolic syndrome and favor cardiovascular and kidney disease.Slective renal denervation is an emerging area of interest in the clinical management of obesity-related hypertension.This review focuses on current understanding of some mechanisms through which sympathetic overactivity may be related to metabolic syndrome,with particular regard to the role of insulin resistance and of some adipokines.

参考文献/References:

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更新日期/Last Update: 2016-07-25