参考文献/References:
[1] Wang X,Yu C,Zhang B,et al. The injurious effects of hyperinsulinism on blood vessels[J]. Cell Biochem Biophys,2014,69(2):213-218.
[2] Marini MA,Frontoni S,Succurro E,et al. Insulin clearance is associated with carotid artery intima-media thickness[J]. Atherosclerosis,2013,229(2):453-458.
[3] Durham TB,Toth JL,Klimkowski VJ,et al. Dual exosite-binding inhibitors of insulin-degrading enzyme challenge its role as the primary mediator of insulin clearance in vivo[J]. J Biol Chem,2015,290(33):20044-20059.
[4] Kotronen A, Vehkavaara S, Seppala-Lindroos A, et al. Effect of liver fat on insulin clearance[J]. Am J Physiol Endocrinol Metab,2007,293(6):E1709-E1715.
[5] Lee CC,Lorenzo C,Haffner SM, et al. The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study(IRAS)[J]. Diabetologia,2013,56(1):112-120.
[6] Goodarzi MO, Guo X, Cui J, et al. Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance[J]. Diabetologia,2013,56(6):1282-1290.
[7] Natali A, Ribeiro R, Baldi S, et al. Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion[J]. Diabetologia,2013, 56(5):1183-1191.
[8] Jinnouchi H,Sugiyama S,Yoshida A,et al. Liraglutide,a glucagon-like peptide-1 analog,increased insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp examination in patients with uncontrolled type 2 diabetes mellitus[J]. J Diabetes Res, 2015,2015:706416.
[9] Pivovarova O,Bernigau W,Bobbert T,et al. Hepatic insulin clearance is closely related to metabolic syndrome components[J]. Diabetes Care,2013,36(11):3779-3785.
[10] Rudovich N, Pivovarova O, Fisher E, et al. Polymorphisms within insulin-degrading enzyme(IDE)gene determine insulin metabolism and risk of type 2 diabetes[J]. J Mol Med(Berl),2009,87(11):1145-1151.
[11] Lee CC, Haffner SM, Wagenknecht LE, et al. Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans:the IRAS Family Study[J]. Diabetes Care,2013,36(4):901-907.
[12] Lorenzo C, Hanley AJ, Wagenknecht LE, et al. Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in a multiethnic population: the Insulin Resistance Atherosclerosis Study[J]. Diabetes Care,2013,36(1):101-103.
[13] Tamaki M,Fujitani Y,Hara A,et al. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance[J]. J Clin Invest,2013,123(10):4513-4524.
[14] Kim MK, Reaven GM, Chen YI, et al. Hyperinsulinemia in individuals with obesity: role of insulin clearance[J]. Obesity(Silver Spring),2015,23(12):2430-2434.
[15] Ader M, Stefanovski D, Kim SP, et al. Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog[J]. Obesity(Silver Spring), 2014, 22(5):1238-1245.
[16] Lee CC, Haffner SM, Wagenknecht LE, et al. Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans:the IRAS Family Study[J]. Diabetes Care,2013,36(4):901-907.
[17] Penesova A, Koska J, Ortega E, et al. Salsalate has no effect on insulin secretion but decreases insulin clearance:a randomized, placebo-controlled trial in subjects without diabetes[J]. Diabetes Obes Metab,2015,17(6):608-612.
[18] Wei X, Ke B, Zhao Z, et al. Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice[J]. PLoS One,2014,9(4):e95399.
[19] Abraham A, Rubin M, Accili D, et al. Hypoglycemia secondary to sulfonylurea ingestion in a patient with end stage renal disease: results from a 72-hour fast[J]. Case Rep Endocrinol,2015,2015:742781.
[20] Nadkarni GN, Yacoub R, Coca SG. Update on glycemic control for the treatment of diabetic kidney disease[J]. Curr Diab Rep,2015,15(7):42.
[21] Mittelman SD,van Citters GW,Kim SP,et al. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response[J]. Diabetes,2000,49(12):2116-2125.
[22] 涂晶,洪涛,文格波. 高胰岛素血症与动脉粥样硬化研究现状与进展[J]. 中国动脉硬化杂志,2013,(01):79-83.
[23] Wang X,Yu C,Zhang B,et al. The injurious effects of hyperinsulinism on blood vessels[J]. Cell Biochem Biophys,2014,69(2):213-218.
[24] Joseph JJ, Donner TW. Long-term insulin glargine therapy in type 2 diabetes mellitus: a focus on cardiovascular outcomes[J]. Vasc Health Risk Manag,2015,11:107-116.
[25] Potenza MA, Marasciulo FL, Chieppa DM, et al. Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production[J]. Am J Physiol Heart Circ Physiol,2005,289(2):H813-H822.
[26] Zhang Y,Wang Y,Wang X,et al. Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated downregulation of p21[J]. J Hypertens,2011,29(8):1560-1568.
[27] Tsiotra PC, Boutati E, Dimitriadis G, et al. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells[J]. Biomed Res Int,2013,2013:487081.
[28] Lee CC,Lorenzo C,Haffner SM,et al. The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study(IRAS)[J]. Diabetologia,2013,56(1):112-120.
[29] Caravaggio JW, Hasu M, Maclaren R, et al. Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice[J]. Cardiovasc Pathol,2013,22(6):458-464.