[1]张培,综述,刘剑,等.慢性心力衰竭并发肌少症的研究进展[J].心血管病学进展,2016,(3):275-278.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.015]
 ZHANG Pei,LIU Jian.Research Progress in Chronic Heart Failure-induced Sarcopenia[J].Advances in Cardiovascular Diseases,2016,(3):275-278.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.015]
点击复制

慢性心力衰竭并发肌少症的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
275-278
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
Research Progress in Chronic Heart Failure-induced Sarcopenia
作者:
张培综述刘剑审校
重庆医科大学附属第一医院心血管内科,重庆 400016
Author(s):
ZHANG Pei LIU Jian
Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
关键词:
慢性心力衰竭 肌少症 研究进展
Keywords:
Chronic heart failure Sarcopenia Research progress
分类号:
R 541.6+1
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.015
文献标志码:
A
摘要:
肌少症是慢性心力衰竭患者的常见并发症,也是影响慢性心力衰竭患者预后的重要危险因素之一。近年来的研究表明,血管紧张素Ⅱ、肌肉生长抑制素、促炎症因子、胰岛素样生长因子-1、卵泡抑制素和睾酮参与了慢性心力衰竭并发肌少症的病理过程,体育锻炼、血管紧张素转换酶抑制剂和必需氨基酸等可治疗慢性心力衰竭并发的肌少症,对此做一综述。
Abstract:
Sarcopenia is a common complication of chronic heart failure and one of the most important risk factors influencing prognosis of chronic heart failure patients. Research studies in recent years indicate that angiotensinⅡ, pro-inflammatory cytokines, myostatin, insulin-like growth factor-1, follistatin and testosterone play roles in the pathogenesis of sarcopenia induced by chronic heart failure. Moreover, physical exercise, angiotensin converting enzyme inhibitor and essential amino acid have therapeutic effects in the treatment of chronic heart failure-induced sarcopenia. The research progress of these fields was reviewed in this paper.

参考文献/References:

[1] Loncar G,Fülster S,von Haehling S,et al.Metabolism and the heart: an overview of muscle, fat,and bone metabolism in heart failure[J].Int J Cardiol,2013,162(2):77-85.
[2] Fülster S,Tacke M,Sandek A, et al.Muscle wasting in patients with chronic heart failure:results from the studies investigating comorbidities aggravating heart failure(SICA-HF)[J]. J Eur Heart,2013,34(7):512-519.
[3] Haykowsky MJ,Brubaker PH,Morgan TM,et al.Impaired aerobic capacity and physical functional performance in older heart failure patients with preserved ejection fraction: role of lean body mass[J]. J Gerontol A Biol Sci Med Sci,2013,68(8):968-975.
[4] Narumi T,Watanabe T,Kadowaki S,et al.Sarcopenia evaluated by fat-free mass index is an important prognostic factor in patients with chronic heart failure[J]. Eur J Intern Med,2015,26(2):118-122.
[5] Cabello-Verrugio C, Córdova G, Salas JD.Angiotensin Ⅱ: role in skeletal muscle atrophy[J]. Curr Protein Pept Sci,2012,13(6):560-569.
[6] Sukhanov S,Semprun-Prieto L,Yoshida T,et al.AngiotensinⅡ,oxidative stress and skeletal muscle wasting[J].Am J Med Sci,2011,342(2):143-147.
[7] Yoshida T,Galvez S,Tiwari S,et al.AngiotensinⅡ inhibits satellite cell proliferation and prevents skeletal muscle regeneration[J]. J Biol Chem,2013,288(33):23823-23832.
[8] Yoshida T, Huq TS, Delafontaine P. Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration[J]. J Biol Chem,2014,289(38):26239-26248.
[9] Elkina Y, von Haehling S, Anker SD, et al.The role of myostatin in muscle wasting:an overview[J]. J Cachexia Sarcopenia Muscle,2011,2(3):143-151.
[10] Heineke J, Auger-Messier M, Xu J,et al.Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure[J].Circulation,2010,121(3):419-425.
[11] Gielen S, Sandri M, Kozarez I,et al.Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig exercise intervention in chronic heart failure and aging catabolism study[J]. Circulation,2012,125(22):2716-2727.
[12] Lenk K, Erbs S, Höllriegel R,et al.Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure[J]. Eur J Cardiovasc Prev Rehabil,2012,19(3):404-411.
[13] Murphy KT,Koopman R,Naim T,et al. Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function[J]. FASEB J,2010,24(11):4433-4442.
[14] Busquets S, Toledo M, Orpí M,et al.Myostatin blockage using actRⅡB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance[J]. J Cachexia Sarcopenia Muscle,2012,3(1):37-43.
[15] Reid MB, Li YP. Tumor necrosis factor-alpha and muscle wasting: a cellular perspective[J]. Respir Res, 2001,2(5):269-272.
[16] Schulze PC, Gielen S, Adams V,et al. Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulin like growth factor-I in chronic heart failure[J]. Basic Res Cardiol,2003,98(4):267-274.
[17] Toth MJ, Ades PA, Tischler MD, et al.Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failure[J]. Int J Cardiol,2006,109(2):179-187.
[18] Schiaffino S, Mammucari C. Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models[J]. Skeletal Muscle,2011,1(1):4.
[19] Hambrecht R, Schulze PC, Gielen S, et al. Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure[J]. Eur J Cardiovasc Prev Rehabil,2005,12(4):401-406.
[20] Iellamo F, Volterrani M, Calminti G, et al.Testosterone therapy in women with chronic heart failure. A pilot double-blind, randomized, placebo-controlled study[J]. J Am Coll Cardiol,2015,56(16):1310-1316.
[21] Lima AR, Martinez PF, Okoshi K,et al. Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure[J]. Int J Exp Pathol,2010,91(1):54-62.
[22] Jankowska EA, Biel B, Majda J, et al. Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival[J]. Circulation,2006,114(17):1829-1837.
[23] Jankowska EA, Filippatos G, Ponikowska B,et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure[J]. J Card Fail,2009,15(5):442-450.
[24] Cunha TF, Bacurau AV, Moreira JB,et al.Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure[J].PLoS One,2012,7(8):e41701.
[25] Smart NA, Steele M. The effect of physical training on systemic proinflammatory cytokine expression in heart failure patients: a systematic review[J]. Congest Heart Fail, 2011,17(3):110-114.
[26] Hsieh PL, Wu YT, Chao WJ. Effects of exercise training in heart transplant recipients:a meta-analysis[J]. Cardiology,2011,120(1):27-35.
[27] Onder G, Penninx BW, Balkrishnan R,et al.Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women:an observational study[J]. Lancet,2002,359(9310):926-930.
[28] Aquilani R, Opasich C, Gualco A,et al. Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure[J]. Eur J Heart Fail,2008,10(11):1127-1135.
[29] Wandrag L,Brett SJ,Frost G,et al. Impact of supplementation with amino acids or their metabolites on muscle wasting in patients with critical illness or other muscle wasting illness:a systematic review[J]. J Hum Nutr Diet,2015,28(4):313-330.
[30] Caminiti G, Volterrani M, Iellamo F,et al.Effect of long-acting testosterone treatment on functional capacity, skeletal muscle performance, and baroreflex sensitivity in elderly patients with chronic heart failure[J].J Am Coll Cardiol,2009,54(10):919-927.
[31] Palus S, Schur R, Akashi YJ, et al.Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model[J]. PLoS One,2011,6(11):e26865.

相似文献/References:

[1]戴玫,付珞,胡建英,等.慢性心力衰竭患者应用高强度间歇性有氧训练研究进展[J].心血管病学进展,2016,(3):271.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.014]
 DAI Mei,FU Luo,HU Jianying,et al.Advances in Research on High-intensity Interval Training in Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2016,(3):271.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.014]
[2]田晶,张青,张岩波,等.慢性心力衰竭结局评价指标研究进展[J].心血管病学进展,2019,(6):931.[doi:10.16806/j.cnki.issn.1004-3934.2019.0.023]
 TIAN Jing,ZHANG qing,ZHANG Yanbo,et al.Outcome Indicators for Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2019,(3):931.[doi:10.16806/j.cnki.issn.1004-3934.2019.0.023]
[3]胡威,苏芳菊,张卫泽.左室四极导线在心脏再同步化治疗中的应用进展[J].心血管病学进展,2020,(3):268.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.013]
 HU Wei,SU Fangju,ZHANG Weize.Application of Left Ventricular Quadrupole in Cardiac Resynchronization Therapy[J].Advances in Cardiovascular Diseases,2020,(3):268.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.013]
[4]郭岐龙 芦颜美 张玲 张疆华 邢强 祖克拉·吐尔洪 李耀东 周贤惠 汤宝鹏.新疆地区老年慢性心力衰竭住院患者的病因、合并症及药物治疗的多中心回顾性分析[J].心血管病学进展,2020,(4):414.[doi:10.16806/j.cnki.issn.1004-3934.2020.04.021]
 GUO Qilong,LU Yanmei,ZHANG Ling,et al.Etiology, Comorbidity and Drug Treatment of Elderly Inpatients with Chronic Heart Failure in Xinjiang: A Multi-center Retrospective Study[J].Advances in Cardiovascular Diseases,2020,(3):414.[doi:10.16806/j.cnki.issn.1004-3934.2020.04.021]
[5]毛玉琳 何胜虎.2型糖尿病和慢性心力衰竭[J].心血管病学进展,2020,(5):491.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.012]
 MAO Yulin,HE Shenghu.Type 2 Diabetes Mellitus and Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2020,(3):491.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.012]
[6]郭曦滢,孙煌,樊朝美,等.非奈利酮治疗慢性心力衰竭的研究进展[J].心血管病学进展,2020,(10):1021.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.006]
 GUO XiyingSUN HuangFAN ChaomeiZHANG Jian.Finerenone in the Treatment of Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2020,(3):1021.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.006]
[7]吴燕婷 李萍 吴寒.慢性心力衰竭再住院率研究进展[J].心血管病学进展,2021,(8):691.[doi:10.16806/j.cnki.issn.1004-3934-2021.08.005]
 WU Yanting,LI Ping,WU Han.Rehospitalization Rate of Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2021,(3):691.[doi:10.16806/j.cnki.issn.1004-3934-2021.08.005]
[8]陈晓梅 陈巧玮 曾纪娟 张庆.可穿戴设备在慢性心力衰竭患者管理中的应用进展[J].心血管病学进展,2023,(3):233.[doi:10.16806/j.cnki.issn.1004-3934.2023.03.010]
 CHEN Xiaomei,CHEN Qiaowei,ZENG Jijuan,et al.Application of Wearable Devices in Management of Patients with Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2023,(3):233.[doi:10.16806/j.cnki.issn.1004-3934.2023.03.010]
[9]李彤 呼海娟 崔炜.慢性心力衰竭患者脑钠肽抵抗机制的研究进展[J].心血管病学进展,2023,(3):238.[doi:10.16806/j.cnki.issn.1004-3934.2023.03.011]
 LI Tong,HU Haijuan,CUI Wei.Mechanism of Brain Natriuretic Peptide Tolerance in Patients with Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2023,(3):238.[doi:10.16806/j.cnki.issn.1004-3934.2023.03.011]
[10]高亮 芦颜美.慢性心力衰竭并发肌少症和恶病质的诊治进展[J].心血管病学进展,2023,(7):598.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.006]
 GAO Liang,LU Yanmei.Diagnosis and Treatment of Chronic Heart Failure Complicated with Sarcopenia and Cachexia[J].Advances in Cardiovascular Diseases,2023,(3):598.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.006]

备注/Memo

备注/Memo:
作者简介:张培(1990—),住院医师,硕士,主要从事心血管研究。Email:zhangpei0813@126.com 通信作者:刘剑(1996—),副主任医师,副教授,研究生导师,主要从事心血管研究。Email: liujian819@126.com
更新日期/Last Update: 2016-05-25