[1]陈艳,综述,袁晋青,等.替格瑞洛临床应用新进展[J].心血管病学进展,2016,(3):235-239.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.005]
 CHEN Yan,YUAN Jinqing.The Updates of Ticagrelor Use in Clinical Practice[J].Advances in Cardiovascular Diseases,2016,(3):235-239.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.005]
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替格瑞洛临床应用新进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
235-239
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
The Updates of Ticagrelor Use in Clinical Practice
作者:
陈艳综述袁晋青审校
中国医学科学院 阜外医院,北京 100037
Author(s):
CHEN Yan YUAN Jinqing
Department of Cardiology, Cardiovascular Institute and Fuwai Hospital,Chinese Academy of Medical Sciences, Beijing 100037, China
关键词:
替格瑞洛 P2Y12受体拮抗剂 抗血小板治疗
Keywords:
Ticagrelor P2Y12 receptor antagonist Antiplatelet therapy
分类号:
R973; R541.4
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.005
文献标志码:
A
摘要:
阿司匹林联合氯吡格雷双联抗血小板治疗是急性冠状动脉综合征的基础治疗。氯吡格雷经肝酶激活起效,抗血小板作用因基因多态性而异。替格瑞洛是新一代非噻吩吡啶类抗血小板药,直接选择性与P2Y12受体结合,抑制腺苷二磷酸介导的血小板聚集。研究显示替格瑞洛抗血小板作用更强,改善急性冠状动脉综合征患者心血管结局且不增加主要出血风险,但在PLATO研究美国人群和PHILO研究东亚人群中未见获益。现重点阐述替格瑞洛临床应用新进展。替格瑞洛在稳定性冠心病治疗中的定位尚需更多临床证据。
Abstract:
The clinical benefits of dual antiplatelet therapy(aspirin + clopidogrel)in the management of acute coronary disease are well established.Clopidogrel requires hepatic activation and produces variable platelet inhibition based on genetic polymorphisims. Ticagrelor, the member of the nonthienopyridines, is an orally active, selective P2Y12 receptor antagonist, thereby inhibiting ADP-mediated platelet response. Ticagrelor shows greater platelet inhibition improved cardiovascular outcomes than clopidogrel, while has a comparable major bleeding risk in the management of acute coronary syndrome.We also find the lack of benefits in PHILO population and the patients erolled from USA in the PLATO study. This article focuses on the updates of ticagrelor use in clinical practice. More data required to definitively position ticagrelor in the management of stable coronary heart disease.

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备注/Memo

备注/Memo:
基金项目:“十二五”国家科技支撑计划项目(2011BAI11B07); 国家自然科学基金(81470486) 作者简介:陈艳(1986—),住院医师,博士,主要从事心血管内科研究。Email: chen_yan04@163.com 通信作者:袁晋青(1962—),主任医师,博士生导师,博士,主要从事心血管内科研究。Email: jqyuan29007@sina.com
更新日期/Last Update: 2016-05-25