[1]胡康新,潘洁,姚文亮.Brugada综合征若干临床进展[J].心血管病学进展,2016,(1):94-97.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.025]
 HU Kangxin,PAN Jie,YAO Wenliang.Clinical Advances on Brugada Syndrome[J].Advances in Cardiovascular Diseases,2016,(1):94-97.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.025]
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Brugada综合征若干临床进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年1期
页码:
94-97
栏目:
综述
出版日期:
2016-02-20

文章信息/Info

Title:
Clinical Advances on Brugada Syndrome
作者:
胡康新潘洁姚文亮
南昌市医学科学研究所,江西 南昌 330001
Author(s):
HU KangxinPAN JieYAO Wenliang
Nanchang City Institute of Medical Science, Nanchang 330001, Jiangxi, China
关键词:
Brugada综合征 早期复极 J波综合征 射频导管消融
Keywords:
Brugada syndrome Early repolarization J wave syndrome Radiofrequency catheter ablation
分类号:
R5442.8
DOI:
10.16806/j.cnki.issn.1004-3934.2016.01.025
文献标志码:
A
摘要:
Brugada综合征是一遗传性致心律失常疾病,显示右心前导联(V1~V2)ST段抬高与T波倒置,而心脏结构正常。易发生心室颤动和心脏性猝死。晕厥、夜间濒死性呼吸和心脏停搏是其常见症状。近年来,Brugada综合征的研究取得了一些进展:如揭示隐匿性Brugada 1型心电图的方法,除了药物实验外,还发现将右心前导联放置在第2肋间; 用24 小时动态心电图监测; 早期复极(J波)对Brugada综合征预后判断有很大价值。以前,射频导管消融只针对右室流出道的外膜,现在
Abstract:
Brugada syndrome is an inherited arrhythmogenic disorder that exhibits electrocadiographic ST-segment elevation with a negative T-wave in the right precordial leads(V1~V2)with normal heart structure, predisposing to ventricular fibrillation and sudden cardiac death.Its symptoms include syncope, nocturnal agonal respiration and cardiac arrest. Recently research on Brugada syndrome has achieved several advances, such as early repolarization(J wave)to aid prognosis of Brugada syndrome and the change from radiofrequency catheter ablation only applied in the epicardium of right ventricular outflow tract in the past to application in the endocardium of right ventricular outflow tract today. Therefore the endocardium of right ventricular outflow tract can be considered as an alternative site in the treatment of recurrent ventricular fibrillation in Brugada syndrome. Regarding exposing concealed Brugada 1 type electrogram,besides pharmacological provocation, there are two other methods: putting right precordial leads on the second intercostal space or Holter monitoring.

参考文献/References:

[1] Brugada R,Campuzano O,Serguella-Brugada G,et al.Brugada syndrome[J].Methodist Debakeg Cardiovasc, 2014,10(1):25-28.
[2] Antzelevitch C,Nof E.Burgada syndrome:recent advance and controversies[J].Curr Cardiol Rep,2008, 10(5):376-383.
[3] Cerrato N,Givstetto C,Gribaude E,et al.Prevalence of type 1 Brugada electrocardiographic pattern evaluated by twelve lead twenty-four-hour Holter monitoring[J].Am J Cardiol,2015,115(1):52-56.
[4] Antzelevitch C,Brugada P,Brugada J,et al.Brugada syndrome:from cell to bedside[J].Curr Probl Cardiol, 2005,30(1):9-54.
[5] 李翠兰,胡大一.心脏离子通道病引起的晕厥[J].心血管病学进展,2006,27(4):409-410.
[6] Uzieblo-Zyczkowsk B,Gielerak G,Michalkiewicz D.Usefulness of patients history and noninvasive electrocardiographic patterns in prediction of ajmaline test results in patients with suspected Brugada syndrome[J].Arch Med Sci,2014,10(5):899-912.
[7] Conte G,Sieira J,Sarkozy A,et al.Life-threatening ventricular arrhythmias during ajmaline challenge in patients with Brugada syndrome:incidencs,clinical feature and prognosis[J].Heart Rhythm,2013,10(12):1869-1874.
[8] Dubner S,Azocar D,Gallino S,et al.Single oral flecainide does to unmask type 1 Brugada syndrome electrocardiographic pattern[J].Ann Noninvasive Electrocardiol,2013,18(3):256-261.
[9] Calvo D,Rubin JM,Perez D,et al.Time-dependent response to provocative testing with flecainide in the diagnosis of Brugada syndrome[J].Heart Rhythm,2015,12(2):350-357.
[10] Anselm DD,Evans JM,Baranchuk A,et al.Brugada phenocopy:a new electrocardiogram phenomenon[J]. World J Cardiol,2014,6(3):81-86.
[11] Oreto G,Corrado D,Delise P,et al.Doubts of the cardiologist regarding an electrocardiogram presenting QRS V1-V2 complexes with positive terminal wave and ST segment elevation.Conensus conference promoted by the Italian Cardiology Society[J].G Ital Cardiol(Rome),2010,11(Suppl 2):3S-22S.
[12] Antzelevitch C.J wave syndrome:molecular and cellular mechanisms[J].J Electrocardiol,2013,46(6):510-518.
[13] Razus C,Flona M,Moga VD,et al.Early repolarization syndrome:electroardiographic sign and clinical implications[J].Ann Noninvasive Electrocardiol,2014,14(1):15-22.
[14] Antzelevitch C,Yan GX.J wave syndrome[J].Heart Rhythm,2010,7(4):549-558.
[15] Levy S,Sbraqia P.ECG repolarization syndrome abnormalitics(J wave syndrome)and idiopathic ventricular fibrillation[J].J Interv Card Electrophysiol,2011,32(3):181-186.
[16] Mizusawa Y,Bezzina CR.Early repolarization pattern:its ECG characteristic,arrhythmogeneity and heritability[J].J Interv Card Electrophysiol,2014,39(3):185-192.
[17] Kawata H,Morita H,YamadaY,et al.Prognostic significance of early repolarization in inferiolateral leads in Brugada patients with documented ventricular fibrillation:a novel risk factor for Brugada syndrome with ventricular fibrillation[J].Heart Rhythm,2013,10(8):1161-1168.
[18] Takaqi M,Aonumak K,Sakiquchi Y,et al.The prognostic value of early repolarization(J wave)and ST-segment morphology after J wave in Brugada syndrome multicenter study in Japan[J].Heart Rhythm,2013,10(4):533-539.
[19] Szeplaki G,Ozcan EE,Qsztheimer I,et al.Ablation of the epicardial substrate in the right ventricular outflow tract in a patient with Brugada syndrome refusing implantable cardioverter defibrillator therapy[J].Can J Cardiol,2014,30(10):1249.e9-1249.e11.
[20] Conte G,Sieira J,Ciconte G,et al.Implantable cardioverter-defibrillator therapy in Brugada syndrome:a 20 year single-center experience[J].J Am Coll Cardiol,2015,65(9):879-888.
[21] Hsiao PY,Tien HC,Lo CP,et al.Gene mutations in cardiac arrhythmias:a review of recent evidence in ion channelopathies[J].Appl Clin Genet,2013,6:1-13.
[22] Nademanee K,Veerakul G,Chandanamattha P,et al.Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium[J].Circulation,2011,123(12):1270-1279.
[23] Sunsaneewitayakul B,Yao Y,Thamaree S,et al.Endocardial mapping and catheter ablation for ventricular fibrillation in Brugada syndrome[J].J Cardiovasc Electrophysiol,2012,23(Suppl 1):S10-S16.
[24] Fish JM,Welchons DR,Kim Y, et al. Dimethyl lithospermate B: an extract of danshen surpresses arrhythmogenesis associated with the Brugada syndrome[J].Circulation,2006,113(11):1393-1400.

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备注/Memo

备注/Memo:
作者简介:胡康新(1932—),主任医师,本科,主要从事医学信息研究。Email:hupei7758521@163.com
更新日期/Last Update: 2016-02-20