[1]韩雅君,朱慧,王丽媛,等.虚拟组织学对急性冠状动脉综合征患者斑块评价研究进展[J].心血管病学进展,2015,(5):641-645.[doi:10.3969/j.issn.1004-3934.2015.05.031]
 HAN Yajun,ZHU Hui,WANG Liyuan,et al.Evaluating Plaque in Patients with Acute Coronary Syndrome by Intravascular Ultrasound with Virtual Histology[J].Advances in Cardiovascular Diseases,2015,(5):641-645.[doi:10.3969/j.issn.1004-3934.2015.05.031]
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虚拟组织学对急性冠状动脉综合征患者斑块评价研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2015年5期
页码:
641-645
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Evaluating Plaque in Patients with Acute Coronary Syndrome by Intravascular Ultrasound with Virtual Histology
作者:
韩雅君1朱慧1王丽媛1何涛2
1.内蒙古自治区人民医院心内科,内蒙古 呼和浩特 010017; 2.内蒙古自治区人民医院急诊科,内蒙古 呼和浩特 010017
Author(s):
HAN Yajun1ZHU Hui1WANG Liyuan1HE Tao2
1.Department of Cardiology, Inner Mongolia Peoples Hospital, Huhhot 010017, Inner Mongolia, China; 2.Department of Emergency, Inner Mongolia People's Hospital, Huhhot 010017, Inner Mongolia, China
关键词:
急性冠状动脉综合征 血管内超声 虚拟组织学
Keywords:
acute coronary syndrome intravascular ultrasound virtual histology
分类号:
R543.3
DOI:
10.3969/j.issn.1004-3934.2015.05.031
文献标志码:
A
摘要:
人们一直不断探索冠心病发生发展的病理机制,积极探索易损斑块、易损病变、易损患者的识别方法,减少心血管事件。血管内超声虚拟组织学是研究冠状动脉病变特征的简单有效的手段之一。近期对于急性冠状动脉综合征的血管内超声虚拟组织学研究显示薄帽纤维粥样硬化斑块与长期的不良心血管事件相关。冠状动脉不同部位发生易损斑块的概率不同。吸烟、高胆固醇血症与斑块不稳定性相关。他汀类药物可减少斑块容积,但是对斑块成分的影响仍不明确。目前仍无可靠的血清学标志物显示冠状动脉斑块的易损性。
Abstract:
The pathological mechanism behind the occurrence and development of coronary heart disease(CHD)is a topic that is consistently researched in efforts to reduce cardiac events. The methodology has focused on vulnerable lesions, plaques and patients. Intravascular ultrasound virtual histology is one of the simplest and most effective means to study coronary artery lesion characteristics. The recent virtual histology intravascular ultrasound study about acute coronary syndrome shows that thin-cap fibroatheroma plaques are associated with long-term adverse cardiovascular events. Vulnerable plaques, occur along different stages of coronary artery risk. Cigarette smoking and high cholesterol are both associated with plaque instability. Statins/medicines can reduce plaque volume, but the impact on the plaque composition is still uncertain. There are still no serological markers that show coronary artery plaque vulnerability.

参考文献/References:

[1] Virmani R, Kolodgie FD, Burke AP, et al. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage[J]. Arterioscler Thromb Vasc Biol, 2005,25(10):2054-2061.
[2] Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular radiofrequency data analysis[J]. Circulation,2002,106(17):2200-2206.
[3] Kolodgie FD, Virmani R, Burke AP, et al. Pathologic assessment of the vulnerable human coronary plaque[J]. Heart,2004,90(12):1385-1391.
[4] Rodriguez-Granillo GA, Garcia-Garcia HM, Mc Fadden EP, et al. In vivo intravascular ultrasound-derived thin-cap fibroatheroma detection using ultrasound radiofrequency data analysis[J]. J Am Coll Cardiol, 2005,46(11):2038-2042.
[5] Stone GW, Maehara A, Lansky AJ, et al.A prospective natural-history study of coronary atherosclerosis[J]. N Engl J Med,2011,364(3):226-235.
[6] Yun KH, Mintz GS, Farhat N, et al. Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events(from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree study)[J]. Am J Cardiol,2012,110(4):471-477.
[7] Dohi T, Mintz GS, McPherson JA, et al.Non-fibroatheroma lesion phenotype and long-term clinical outcomes: a substudy analysis from the PROSPECT study[J]. JACC Cardiovasc Imaging, 2013,6(8):908-916.
[8] Xie Y, Mintz GS, Yang J,et al. Clinical outcome of nonculprit plaque ruptures in patients with acute coronary syndrome in the PROSPECT study[J]. JACC Cardiovasc Imaging,2014,7(4):397-405.
[9] Inaba S, Mintz GS, Farhat NZ,et al. Impact of positive and negative lesion site remodeling on clinical outcomes: insights from PROSPECT[J]. JACC Cardiovasc Imaging,2014,7(1):70-78.
[10] Noto T, Kameyama T, Satoh T,et al. Association between virtual histology intravascular ultrasound findings and subsequent coronary events in patients with acute coronary syndrome[J]. Int Heart J,2015,56(2):157-162.
[11] Sonneveld MA, Cheng JM, Oemrawsingh RM,et al. Von Willebrand factor in relation to coronary plaque characteristics and cardiovascular outcome. Results of the ATHEROREMO-IVUS study[J]. Thromb Haemost,2015,113(3):577-584.
[12] Battes LC, Akkerhuis KM, Cheng JM, et al. Circulating acute phase proteins in relation to extent and composition of coronary atherosclerosis and cardiovascular outcome: results from the ATHEROREMO-IVUS study[J]. Int J Cardiol,2014,177(3):847-853.
[13] Cheng JM, Oemrawsingh RM,Garcia-Garcia HM,et al. Relation of C-reactive protein to coronary plaque characteristics on grayscale, radiofrequency intravascular ultrasound, and cardiovascular outcome in patients with acute coronary syndrome or stable angina pectoris(from the ATHEROREMO-IVUS study)[J].Am J Cardiol,2014,114(10):1497-1503.
[14] Battes LC, Cheng JM, Oemrawsingh RM, et al.Circulating cytokines in relation to the extent and composition of coronary atherosclerosis: results from the ATHEROREMO-IVUS study[J]. Atherosclerosis, 2014,236(1):18-24.
[15] Cheng JM, Oemrawsingh RM, Akkerhuis KM, et al. Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome[J]. Biomarkers, 2014,19(7):611-619.
[16] Siqueira DA, Sousa AG, Costa Junior Jde R, et al. Correlation between plaque composition as assessed by virtual histology and C-reactive protein [J]. Arq Bras Cardiol,2013,101(1):78-86.
[17] Seo YH, Lee CS, Yuk HB,et al. Hypercholesterolemia and in-vivo coronary plaque composition in patients with coronary artery disease: a virtual histology-intravascular ultrasound study[J]. Korean Circ J, 2013,43(1):23-28.
[18] Wykrzykowska JJ, Mintz GS, Garcia-Garcia HM, et al. Longitudinal distribution of plaque burden and necrotic core-rich plaques in nonculprit lesions of patients presenting with acute coronary syndromes[J].JACC Cardiovasc Imaging,2012,5(3 Suppl):S10-18.
[19] Hong YJ, Jeong MH, Choi YH, et al. Positive remodeling is associated with vulnerable coronary plaque components regardless of clinical presentation: virtual histology-intravascular ultrasound analysis[J]. Int J Cardiol,2013,167(3):871-876.
[20] Guo J, Maehara A, Mintz GS, et al. A virtual histology intravascular ultrasound analysis of coronary chronic total occlusions [J]. Catheter Cardiovasc Interv, 2013,81(3):464-470.
[21] Lee MG, Jeong MH, Kim DH, et al. Can metabolic syndrome predict the vulnerable plaque in patients with stable angina pectoris? Virtual histology-intravascular ultrasound analysis[J]. J Cardiol, 2012,59(3):266-274.
[22] Schoenenberger AW, Urbanek N, Toggweiler S, et al.Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender[J]. World J Cardiol, 2013,5(3):42-48.
[23] Kang SJ, Mintz GS, Weisz G, et al. Age-related effects of smoking on coronary artery disease assessed by gray scale and virtual histology intravascular ultrasound[J].Am J Cardiol, 2015,115(8):1056-1062.
[24] Dhawan SS, Corban MT, Nanjundappa RA,et al.Coronary microvascular dysfunction is associated with higher frequency of thin-cap fibroatheroma[J].Atherosclerosis, 2012,223(2):384-388.
[25] Ohshima K, Ikeda S, Kadota H,et al.Impact of culprit plaque volume and composition on myocardial microcirculation following primary angioplasty in patients with ST-segment elevation myocardial infarction: virtual histology intravascular ultrasound analysis[J]. Int J Cardiol,2013,167(3):1000-1005.
[26] Ding S, Xu L, Yang F,et al.Association between tissue characteristics of coronary plaque and distal embolization after coronary intervention in acute coronary syndrome patients: insights from a meta-analysis of virtual histology-intravascular ultrasound studies[J]. PLoS One, 2014,9(11):e106583.
[27] Amano H, Wagatsuma K, Yamazaki J, et al.Virtual histology intravascular ultrasound analysis of attenuated plaque and ulcerated plaque detected by gray scale intravascular ultrasound and the relation between the plaque composition and slow flow/no reflow phenomenon during percutaneous coronary intervention[J]. J Interv Cardiol, 2013,26(3):295-301.
[28] Tian J, Gu X, Sun Y, et al. Effect of statin therapy on the progression of coronary atherosclerosis[J]. BMC Cardiovasc Disord, 2012,12:70.
[29] Yang HB, Zhao XY, Zhao YT, et al. Effects of domestic rosuvastatin on coronary plaque in patients with mild-to-moderate coronary artery stenosis as evaluated by virtual histology-intravascular ultrasound[J]. Zhonghua Yi Xue Za Zhi, 2012,92(22):1550-1502.
[30] Nozue T, Yamamoto S, Tohyama S,et al.Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound [J]. Heart Vessels, 2015,30(1):36-44.
[31] Taguchi I, Oda K, Yoneda S,et al. Evaluation of serial changes in tissue characteristics during statin-induced plaque regression using virtual histology-intravascular ultrasound studies[J]. Am J Cardiol, 2013,111(9):1246-1252.
[32] Christoph M, Herold J, Berg-Holldack A, et al. Effects of the PPARγ agonist pioglitazone on coronary atherosclerotic plaque composition and plaque progression in non-diabetic patients: a double-center, randomized controlled VH-IVUS pilot-trial[J]. Heart Vessels, 2015,30(3):286-295.

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备注/Memo

备注/Memo:
作者简介:韩雅君(1964—),主任医师,博士,主要从事冠心病研究。Email:junyahan@sina.com 通信作者:何涛(1961—),主任医师,学士,主要从事急诊医学研究。Email:het1441@163.com
更新日期/Last Update: 2016-05-20