[1]朱佩,袁晋青.P2Y12受体拮抗剂与质子泵抑制剂相互作用的研究进展[J].心血管病学进展,2015,(5):570-574.[doi:10.3969/j.issn.1004-3934.2015.05.012]
 ZHU Pei,YUAN Jinqing.Review of Interactions Between P2Y12 Receptor Antagonists and Proton Pump Inhibitors[J].Advances in Cardiovascular Diseases,2015,(5):570-574.[doi:10.3969/j.issn.1004-3934.2015.05.012]
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P2Y12受体拮抗剂与质子泵抑制剂相互作用的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2015年5期
页码:
570-574
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Review of Interactions Between P2Y12 Receptor Antagonists and Proton Pump Inhibitors
作者:
朱佩袁晋青
中国医学科学院 阜外心血管病医院,北京 100037
Author(s):
ZHU Pei YUAN Jinqing
Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
关键词:
氯吡格雷 P2Y12受体拮抗剂 抗血小板治疗 质子泵抑制剂
Keywords:
clopidogrel P2Y12 receptor antagonist antiplatelet therapy proton pump inhibitors
分类号:
R541.4; R972
DOI:
10.3969/j.issn.1004-3934.2015.05.012
文献标志码:
A
摘要:
质子泵抑制剂可以明显降低急性冠状动脉综合征及经皮冠状动脉介入术后双联抗血小板治疗患者的出血风险,但近年来的研究显示氯吡格雷与质子泵抑制剂相互作用可能导致主要心血管不良事件的增加,对临床工作造成了困扰。现重点阐述P2Y12受体拮抗剂与质子泵抑制剂相互作用的研究进展,并为临床决策提供建议。
Abstract:
Proton pump inhibitors are used to prevent gastrointestinal bleeding from dual-antiplatelet therapy, which reduces major cardiovascular events for patients with acute coronary syndromes and in patients undergoing percutaneous coronary interventions. Over the last few years, conflicting evidence has shown that interactions between clopidegrel and proton pump inhibitors might have contributed to the increased risk of major cardiovascular events. This review focuses on the updates of the current evidences between P2Y12 receptor antagonists and proton pump inhibitors and provides practical implications for clinical practice.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家“十二五”科技支撑计划(2011BAI11B07) 作者简介:朱佩(1987—),住院医师,博士,主要从事心血管内科研究。Email: pipi813@126.com 通信作者:袁晋青(1962—),主任医师,博士生导师,博士,主要从事心血管内科研究。Email: jqyuan29007@sina.com
更新日期/Last Update: 2016-05-20