[1]普露桐 陈玉成.肥厚型心肌病的药物治疗进展[J].心血管病学进展,2024,(2):107.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.003]
 PU L utong,CHEN Yucheng,Advances in Pharmacological Treatment of Hypertrophic Cardiomyopathy[J].Advances in Cardiovascular Diseases,2024,(2):107.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.003]
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肥厚型心肌病的药物治疗进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年2期
页码:
107
栏目:
约稿
出版日期:
2024-02-25

文章信息/Info

Title:
Advances in Pharmacological Treatment of Hypertrophic Cardiomyopathy
作者:
普露桐1 陈玉成12
(1.四川大学华西医院心内科,四川 成都 610041;2.四川大学华西医院罕见病中心,四川成都 610041)
Author(s):
PU L utong 1 CHEN Yucheng1 2
(1. Department of Cardiology, West China School of Medicine West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; 2.Center of Rare Diseases, West China School of Medicine West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China)
关键词:
肥厚型心肌病药物治疗肌球蛋白抑制
Keywords:
Hypertrophic cardiomyopathy Pharmacological treatment M yosin inhibition
DOI:
10.16806/j.cnki.issn.1004-3934.2024.02.003
摘要:
肥厚型心肌病(HCM)是最常见的遗传性心肌病,特点是左心室肥厚、心肌过度收缩及舒张功能障碍。HCM的治疗药物选择有限,包括β受体阻滞剂、钙通道阻滞剂。这些药物不能阻止自然病程进展,也不能有效降低并发症的发生率。近年来,对HCM遗传基础和病理生理机制的了解不断加深,开发了靶向的、可能改善疾病的疗法。现结合最新研究进展,系统地阐述了该病的药物治疗。
Abstract:
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and is characterized by left ventricular hypertrophy, myocardial hypercontraction, and diastolic dysfunction. Pharmacological treatment options of HCM are limited, including beta blockers, calcium channel blockers. These drugs do not prevent progression of the natural history and are not effective in reducing the incidence of complications. In recent years, increased knowledge of the genetic basis and pathophysiological mechanisms of HCM has led to the development of targeted, potentially disease-modifying therapies. In this article, we systematically describe the pharmacological treatment of this disease based on the latest research progress

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更新日期/Last Update: 2024-03-29