[1]崔鸿杰 吴英锋.CYP2C19基因多态性指导抗血小板治疗的研究现状[J].心血管病学进展,2023,(11):1019.[doi:10.16806/j.cnki.issn.1004-3934.2023.11.014]
 Cui Hongjie,Wu Yingfeng.CYP2C19 gene polymorphism for antiplatelet therapy[J].Advances in Cardiovascular Diseases,2023,(11):1019.[doi:10.16806/j.cnki.issn.1004-3934.2023.11.014]
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CYP2C19基因多态性指导抗血小板治疗的研究现状()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年11期
页码:
1019
栏目:
综述
出版日期:
2023-11-25

文章信息/Info

Title:
CYP2C19 gene polymorphism for antiplatelet therapy
作者:
崔鸿杰1 吴英锋2
(1.首都医科大学宣武医院血管外科 北京100053;2.首都医科大学附属北京潞河医院血管外科 北京101199)
Author(s):
Cui Hongjie 1Wu Yingfeng 2
(1.Department of Vascular Surgery,Xuanwu Hospital,Capital Medical University,Beijing,100053,China;2.Department of Vascular Surgery,Luhe Hospital affiliated to Capital Medical University,Beijing,101199,China)
关键词:
CYP2C19基因多态性抗血小板治疗氯吡格雷抵抗
Keywords:
CYP2C19 gene polymorphismantiplatelet therapyclopidogrel resistance
DOI:
10.16806/j.cnki.issn.1004-3934.2023.11.014
摘要:
CYP2C19酶是CYP450细胞色素氧化酶超家族中的一部分。许多临床使用的药物的代谢都由它完成,抗血小板药物氯吡格雷也是其中之一。CYP2C19基因多态性对体内氯吡格雷活性的影响已经得到证实,不同的基因型使机体对氯吡格雷的代谢程度不同,在慢代谢型人群中存在氯吡格雷抵抗会导致治疗失败,使患者产生不良结局。使用替格瑞洛、普拉格雷等新型药物的个体化治疗似乎可以有效减少不良事件的发生。
Abstract:
CYP2C19 enzyme is a part of CYP450 cytochrome oxidase superfamily. It completes the metabolism of many clinical drugs,and clopidogrel,an antiplatelet drug,is one of them. The effect of CYP2C19 gene polymorphism on clopidogrel activity in vivo has been confirmed. Different genotypes lead to different metabolic degrees of clopidogrel in the body,and clopidogrel resistance in the slow metabolism populations will lead to treatment failure and adverse outcomes of patients. Individualized therapy with new drugs such as tigrilol and prasugrel seems to be effective in reducing adverse events.

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