[1]刘丽芳 彭瑜 张钲.急性ST段抬高型心肌梗死患者再灌注后心肌内出血的研究进展[J].心血管病学进展,2022,(5):444-449.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.015]
 LIU Lifang,PENG Yu,ZHANG Zheng.Intracardial Hemorrhage After Reperfusion in Patients with Acute ST-Segment Elevation Myocardial Infarction[J].Advances in Cardiovascular Diseases,2022,(5):444-449.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.015]
点击复制

急性ST段抬高型心肌梗死患者再灌注后心肌内出血的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年5期
页码:
444-449
栏目:
出版日期:
2022-05-25

文章信息/Info

Title:
Intracardial Hemorrhage After Reperfusion in Patients with Acute ST-Segment Elevation Myocardial Infarction
作者:
刘丽芳1 彭瑜 2 张钲 2
(1.兰州大学第一临床医学院,甘肃 兰州 730000;2.兰州大学第一医院心脏中心 甘肃省心血管疾病重点实验室,甘肃 兰州 730000)
Author(s):
LIU Lifang1PENG Yu2ZHANG Zheng2
(1.The First Clinical Medical College,Lanzhou University,Lanzhou 730000,Gansu,China; 2.Heart Center,The First Hospital of Lanzhou University,Key Laboratory of Cardiovascular Diseases of Gansu Province,Lanzhou 730000,Gansu,China)
关键词:
急性ST段抬高型心肌梗死缺血再灌注损伤心肌内出血
Keywords:
ST-segment elevation myocardial infarctionIschemia reperfusion injuryIntracardial hemorrhage
DOI:
10.16806/j.cnki.issn.1004-3934.2022.05.015
摘要:
急性ST段抬高型心肌梗死是心血管疾病中的急危重症,再灌注治疗是首要治疗方法,再灌注损伤是常见并发症之一。心肌内出血是最近发现的一种再灌注损伤,与急性ST段抬高型心肌梗死患者预后不良密切相关。目前人们对心肌内出血的认识不充分,现结合国内外最新文献,对心肌内出血的危险因素、病理机制、预后、诊断和防治等进行综述,为进一步理解心肌内出血提供参考。
Abstract:
Acute ST-segment elevation myocardial infarction(STEMI) is an acute and severe cardiovascular disease. It is primarily treated with reperfusion therapy,and reperfusion injury is one of the common complications. Intramyocardial hemorrhage is a recently found reperfusion injury,which is closely related to the poor prognosis of patients with acute STEMI. At present,people ’s understanding of intramyocardial hemorrhage is insufficient. Therefore,combined with the latest literature at home and abroad,this paper reviews the risk factors,pathological mechanism,prognosis,diagnosis,prevention and treatment of intramyocardial hemorrhage,so as to provide reference for further understanding of intramyocardial hemorrhage

参考文献/References:

[1] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南(2019)[J]. 中华心血管病杂志,2019,47(10):766-783.

[2] Hamirani YS,Wong A,Kramer CM,et al. Effect of microvascular obstruction and intramyocardial hemorrhage by CMR on LV remodeling and outcomes after myocardial infarction:a systematic review and meta-analysis[J]. JACC Cardiovasc Imaging,2014,7(9):940-952.

[3] Bulluck H,Dharmakumar R,Arai AE,et al. Cardiovascular magnetic resonance in acute ST-segment-elevation myocardial infarction:recent advances,controversies,and future directions[J]. Circulation,2018,137(18):1949-1964.

[4] Amier RP,Tijssen RYG,Teunissen PFA,et al. Predictors of intramyocardial hemorrhage after reperfused ST-segment elevation myocardial infarction[J]. J Am Heart Assoc,2017,6(8):e005651.

[5] Nair AR,Johnson EA,Yang HJ,et al. Reperfused hemorrhagic myocardial infarction in rats[J]. PLoS One,2020,15(12):e0243207.

[6] Ma M,Diao KY,Yang ZG,et al. Clinical associations of microvascular obstruction and intramyocardial hemorrhage on cardiovascular magnetic resonance in patients with acute ST segment elevation myocardial infarction(STEMI):an observational cohort study[J]. Medicine(Baltimore),2018,97(30):e11617.

[7] Beijnink CWH,van der Hoeven NW,Konijnenberg LSF,et al. Cardiac MRI to visualize myocardial damage after ST-segment elevation myocardial infarction:a review of its histologic validation[J]. Radiology,2021,301(1):4-18.

[8] 李建辉,魏璇,鲍雪,等. 急性ST段抬高型心肌梗死介入术后心肌内出血的相关因素分析[J]. 中国动脉硬化杂志,2021,29(2):135-142.

[9] Ma?ek ?A,K?opotowski M,?piewak M,et al. Platelet reactivity and intramyocardial hemorrhage in patients with ST-segment elevation myocardial infarction[J]. Clin Appl Thromb Hemost,2014,20(5):553-558.

[10] Arai H,Kawakubo M,Abe K,et al. Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury:a semi-automated image processing technique[J]. Int J Cardiovasc Imaging,2020,36(1):111-119.

[11] 姜子超,刘康,凌维维,等. 急性ST段抬高型心肌梗死直接PCI术后心肌内出血的危险因素分析[J/OL]. 解放军医学杂志.https://kns.cnki.net/kcms/detail/11.1056.R.20220118.1108.004.html.

[12] Amabile N,Jacquier A,Shuhab A,et al. Incidence,predictors,and prognostic value of intramyocardial hemorrhage lesions in ST elevation myocardial infarction[J]. Catheter Cardiovasc Interv,2012,79(7):1101-1108.

[13] Carrick D,Haig C,Ahmed N,et al. Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction:relation to microvascular obstruction and prognostic significance[J]. Circ Cardiovasc Imaging,2016,9(1):e004148.

[14] Tiller C,Reindl M,Holzknecht M,et al. Relationship between admission Q waves and microvascular injury in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention[J]. Int J Cardiol,2019,297:1-7.

[15] Tiller C,Reindl M,Holzknecht M,et al. Association of plasma interleukin-6 with infarct size,reperfusion injury,and adverse remodelling after ST-elevation myocardial infarction[J]. Eur Heart J Acute Cardiovasc Care,2022,11(2):113-123.

[16] 罗一纯,简能日,李如利. 老年急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后心肌内出血的危险因素分析[J]. 中国医药,2021,16(12):1783-1786.

[17] Symons R,Masci PG,Francone M,et al. Impact of active smoking on myocardial infarction severity in reperfused ST-segment elevation myocardial infarction patients:the smoker’s paradox revisited[J]. Eur Heart J,2016,37(36):2756-2764.

[18] Ferré-Vallverdú M,Sánchez-Lacuesta E,Plaza-López D,et al. Prognostic value and clinical predictors of intramyocardial hemorrhage measured by CMR T2* sequences in STEMI[J]. Int J Cardiovasc Imaging,2021,37(5):1735-1744.

[19] Hausenloy DJ,Chilian W,Crea F,et al. The coronary circulation in acute myocardial ischaemia/reperfusion injury:a target for cardioprotection[J]. Cardiovasc Res,2019,115(7):1143-1155.

[20] Avolio E,Madeddu P. Discovering cardiac pericyte biology:from physiopathological mechanisms to potential therapeutic applications in ischemic heart disease[J]. Vascul Pharmacol,2016,86:53-63.

[21] Siao CJ,Lorentz CU,Kermani P,et al. ProNGF,a cytokine induced after myocardial infarction in humans,targets pericytes to promote microvascular damage and activation[J]. J Exp Med,2012,209(12):2291-2305.

[22] Lee LL,Khakoo AY,Chintalgattu V. Cardiac pericytes function as key vasoactive cells to regulate homeostasis and disease[J]. FEBS Open Bio,2021,11(1):207-225.

[23] Kali A,Kumar A,Cokic I,et al. Chronic manifestation of postreperfusion intramyocardial hemorrhage as regional iron deposition:a cardiovascular magnetic resonance study with ex vivo validation[J]. Circ Cardiovasc Imaging,2013,6(2):218-228.

[24] Bulluck H,Rosmini S,Abdel-Gadir A,et al. Residual myocardial iron following intramyocardial hemorrhage during the convalescent phase of reperfused ST-segment-elevation myocardial infarction and adverse left ventricular remodeling[J]. Circ Cardiovasc Imaging,2016,9(10):e004940.

[25] Ghugre NR,Pop M,Thomas R,et al. Hemorrhage promotes inflammation and myocardial damage following acute myocardial infarction:insights from a novel preclinical model and cardiovascular magnetic resonance[J]. J Cardiovasc Magn Reson,2017,19(1):50.

[26] Bochaton T,Lassus J,Paccalet A,et al. Association of myocardial hemorrhage and persistent microvascular obstruction with circulating inflammatory biomarkers in STEMI patients[J]. PLoS One,2021,16(1):e0245684.

[27] Carberry J,Carrick D,Haig C,et al. Persistent iron within the infarct coreafter ST-segment elevation myocardial infarction:implications for left ventricular remodeling and healthoutcomes[J]. JACC Cardiovasc Imaging,2018,11(9):1248-1256.

[28] Garg P,Kidambi A,Foley JR,et al. Ventricular longitudinal function is associated with microvascular obstruction and intramyocardial haemorrhage[J]. Open Heart,2016,3(1):e000337.

[29] Liu T,Howarth AG,Chen Y,et al. Intramyocardial hemorrhage and the “wave front” of reperfusion injury compromising myocardial salvage[J]. J Am Coll Cardiol,2022,79(1):35-48.

[30] Reinstadler SJ,Stiermaier T,Reindl M,et al. Intramyocardial haemorrhage and prognosis after ST-elevation myocardial infarction[J]. Eur Heart J Cardiovasc Imaging,2019,20(2):138-146.

[31] Mather AN,Fairbairn TA,Ball SG,et al. Reperfusion haemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk[J]. Heart,2011,97(6):453-459.

[32] Roghi A,Poggiali E,Duca L,et al. Role of non-transferrin-bound iron in the pathogenesis of cardiotoxicity in patients with ST-elevation myocardial infarction assessed by cardiac magnetic resonance imaging[J]. Int J Cardiol,2015,199:326-332.

[33] Demirkiran A,Everaars H,Amier RP,et al. Cardiovascular magnetic resonance techniques for tissue characterization after acute myocardial injury[J]. Eur Heart J Cardiovasc Imaging,2019,20(7):723-734.

[34] Pavon AG,Georgiopoulos G,Vincenti G,et al. Head-to-head comparison of multiple cardiovascular magnetic resonance techniques for the detection and quantification of intramyocardial haemorrhage in patients with ST-elevation myocardial infarction[J]. Eur Radiol,2021,31(3):1245-1256.

[35] Rossello X,Lopez-Ayala P,Fernández-Jiménez R,et al. R2 prime(R2’) magnetic resonance imaging for post-myocardial infarction intramyocardial haemorrhage quantification[J]. Eur Heart J Cardiovasc Imaging,2020,21(9):1031-1038.

[36] Das A,Kelly C,Teh I,et al. Detection of intramyocardial iron in patients following ST-elevation myocardial infarction using cardiac diffusion tensor imaging[J]. ?J Magn Reson Imaging,2022 Jan 12. DOI :10.1002/jmri.28063. Epub ahead of print.

[37] Zhao H,Lee AP,Li Z,et al. Impact of intramyocardial hemorrhage and microvascular obstruction on cardiac mechanics in reperfusion injury:a speckle-tracking echocardiographic study[J]. J Am Soc Echocardiogr,2016,29(10):973-982.

[38] 王西,王萍. 心肌梗死再灌注治疗后发生心肌内出血的机制研究和防治进展[J]. 心脏杂志,2021,33(5):548-552.

[39] Marc MC,Iancu AC,B?l?nescu ?,et al. Microvascular obstruction in acute myocardial infarction:an old and unsolved mystery[J]. Med Pharm Rep,2019,92(3):216-219.

[40] 邱妍妍,郭继鸿. 心肌内出血及其临床意义[J]. 临床心电学杂志,2021,30(4):305-310.

[41] Zhang CX,Cheng Y,Liu DZ,et al. Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats[J]. J Nanobiotechnology,2019,17(1):18.

[42] Konijnenberg LSF,Damman P,Duncker DJ,et al. Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction[J]. Cardiovasc Res,2020,116(4):787-805.

[43] Betgem RP,de Waard GA,Nijveldt R,et al. Intramyocardial haemorrhage after acute myocardial infarction[J]. Nat Rev Cardiol,2015,12(3):156-167.

[44] Behrouzi B,Weyers JJ,Qi X,et al. Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction[J]. Basic Res Cardiol,2020,115(3):24.

[45] Hwang JW,Park JH,Park BW,et al. Histochrome attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis-induced cardiomyocyte death[J]. Antioxidants(Basel),2021,10(10):1624.

[46] Xu Z,Chen W,Zhang R,et al. Human recombinant apyrase therapy protects against myocardial ischemia/reperfusion injury and preserves left ventricular systolic function in rats,as evaluated by 7T cardiovascular magnetic resonance imaging[J]. Korean J Radiol,2020,21(6):647-659.

[47] Rout A,Tantry US,Novakovic M,et al. Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction[J]. Expert Opin Pharmacother,2020,21(15):1851-1865.

[48] Bulluck H,Chan MHH,Bryant JA,et al. Platelet inhibition to target reperfusion injury trial:rationale and study design[J]. Clin Cardiol,2019,42(1):5-12.

[49] Lahnwong S,Palee S,Apaijai N,et al. Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury[J]. Cardiovasc Diabetol,2020,19(1):91.

[50] Podlesnikar T,Pizarro G,Fernández-Jiménez R,et al. Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction(METOCARD-CNIC randomized clinical trial substudy)[J]. J Cardiovasc Magn Reson,2020,22(1):44.

相似文献/References:

[1]谷阳 史亚非 张刚 张东营 张清.急性ST段抬高型心肌梗死患者血浆中性粒细胞明胶酶相关脂质运载蛋白水平与梗死后心室重构的相关性研究[J].心血管病学进展,2019,(5):836.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.042]
 GU Yang,SHI Yafei,ZHANG Gang,et al.Neutrophil Gelatinase-associated Lipocalin is Associated with Cardiac Remodeling in Patients with ST-segment Elevation Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(5):836.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.042]
[2]陈丰 苏强 朱继金.高迁移率族蛋白B1在心脏炎症反应性疾病中的研究进展[J].心血管病学进展,2019,(8):1111.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.010]
 CHEN Feng,SU Qiang,ZHU Jijin.Research Progress of HMGB1 in Myocardial Inflammatory Reactivity Disease[J].Advances in Cardiovascular Diseases,2019,(5):1111.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.010]
[3]郝明辉 郭明 唐宇 杨婧 柳子静 闫蕊 李萍 郭金成.急性ST段抬高型心肌梗死患者PCI后血清EREG水平及其与预后的关系[J].心血管病学进展,2020,(1):102.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.027]
 HAO Minghui,GUO Ming,TANG Yu,et al.Serum EREG Level after PCI and Its Relationship with Prognosis in Patients with Acute ST-segment Elevation Myocardial Infarction[J].Advances in Cardiovascular Diseases,2020,(5):102.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.027]
[4]赵鸿泽 刘剑雄.急性ST段抬高型心肌梗死介入手术时间窗与心室重塑的相关性研究[J].心血管病学进展,2020,(2):208.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.028]
 ZHAO Hongze,LIU Jianxiong.Correlation between the Onset Time and Ventricular Remodeling in Scute ST-segment Elevation Myocardial Infarction[J].Advances in Cardiovascular Diseases,2020,(5):208.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.028]
[5]肖秋蓓 王志维.急性主动脉夹层并发急性肺损伤研究进展[J].心血管病学进展,2020,(12):1260.[doi:10.16806/j.cnki.issn.1004-3934.2020.12.009]
 XIAO QiubeiWANG Zhiwei.Acute Aortic Dissection Complicated with Acute Lung Injury[J].Advances in Cardiovascular Diseases,2020,(5):1260.[doi:10.16806/j.cnki.issn.1004-3934.2020.12.009]
[6]宋元秀 崔鸣.线粒体动力学异常与相关心血管疾病[J].心血管病学进展,2021,(2):162.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.017]
 SONG Yuanxiu,CUI Ming.Correlation Between Mitochondrial Dynamics and Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2021,(5):162.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.017]
[7]邓媛 李伟 熊信林 段宗刚.急性ST段抬高型心肌梗死救治时间节点对预后影响的研究进展[J].心血管病学进展,2021,(11):1024.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
 DENG Yuan,LI Wei,XIONG Xinlin,et al.Effect of Treatment Time Node on Prognosis of STEMI[J].Advances in Cardiovascular Diseases,2021,(5):1024.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
[8]王娟琳 黄颖.急性心肌梗死后心脏破裂机制的研究进展[J].心血管病学进展,2022,(7):619.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
 WANG Juanlin,HUANG Ying.Mechanism of Cardiac Rupture After Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2022,(5):619.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
[9]谭莹 毛雅晶 马楠 鲍雪 康丽娜 徐标.中性粒细胞与淋巴细胞比值对STEMI再灌注损伤后微血管阻塞的预测价值[J].心血管病学进展,2023,(1):87.[doi:10.16806/j.cnki.issn.1004-3934.2023.01.019]
 TAN YingMAO Yajing MA NanBAO XueKANG LinaXU Biao.Predictive Value of Neutrophil-to-Lymphocyte Ratio for MVO After STEMI Reperfusion Injury[J].Advances in Cardiovascular Diseases,2023,(5):87.[doi:10.16806/j.cnki.issn.1004-3934.2023.01.019]
[10]张兆元 马茜钰 张丹 彭石 张锦.C反应蛋白与高密度脂蛋白胆固醇比值、N末端脑钠肽前体与射血分数比值对STEMI患者PCI术后院内MACE的预测价值研究[J].心血管病学进展,2023,(2):186.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.020]
 ZHANG ZhaoyuanMA QianyuZHANG DanPENG ShiZHANG Jin.The Predictive Value of C-reactive Protein to High Density Lipoprotein Cholesterol Ratio and NT-proBNP to Ejection Fraction Ratio for Hospital MACE in Patients with STEMI After PCI[J].Advances in Cardiovascular Diseases,2023,(5):186.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.020]

更新日期/Last Update: 2022-06-30