[1]邢云 邓伟 唐其柱.Toll样受体与心血管疾病关系的研究进展[J].心血管病学进展,2021,(8):711-715.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.010]
 XING Yun,DENG Wei,TANG Qizhu.Research Progress on the Role of Toll-Like Receptor in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2021,(8):711-715.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.010]
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Toll样受体与心血管疾病关系的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年8期
页码:
711-715
栏目:
综述
出版日期:
2021-08-25

文章信息/Info

Title:
Research Progress on the Role of Toll-Like Receptor in Cardiovascular Diseases
作者:
邢云 邓伟 唐其柱
(武汉大学人民医院心血管内科 代谢与相关慢病湖北省重点实验室,湖北 武汉 430060)
Author(s):
XING YunDENG WeiTANG Qizhu
(Department of Cardiology,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Metabolic and Chronic Diseases,Wuhan 430060,Hubei,China)
关键词:
天然免疫Toll样受体炎性因子心血管疾病
Keywords:
Innate immunityToll-like receptorInflammatory factorCardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2021.08.010
摘要:
心血管疾病是一种严重威胁人类健康的常见病,具有高患病率和高死亡率的特点,全世界每年死于心血管疾病的人数居各种死因首位。免疫调控等因素与心血管疾病的发生和发展密切相关。Toll样受体(TLRs)是一类模式识别受体,主要表达于细胞膜上,且与微生物识别有关。TLRs能识别特定类型微生物相对保守的分子成分,即病原体相关分子模式,通过激活细胞信号传导途径介导天然免疫反应,还可诱导免疫细胞产生细胞因子,帮助机体建立获得性免疫。近年来研究发现TLRs在心血管疾病中发挥重要作用,现对TLRs与临床心血管疾病的关系进行综述,以期为临床干预提供新思路。
Abstract:
Cardiovascular disease is a common disease that seriously threatens human health. It has the characteristics of high morbidity and high mortality. The number of people who die from cardiovascular disease every year in the world ranks first among all causes of death. Immune regulation and other factors are closely related to the occurrence and development of cardiovascular diseases. Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs),which are mainly expressed on cell membranes and related to microbial recognition. TLRs can recognize the relatively conservative molecular components of specific types of microorganisms,which called pathogen-associated molecular patterns (PAMP). TLRS can not only activate the natural immune response mediated by cell signal transduction pathway,but also provide molecules and cytokines that induce T cell differentiation,thus helping the body to establish acquired immunity. Recent studies have found that TLRs plays an important role in cardiovascular diseases. This review provides theoretical basis for the relationship between TLRs and some clinical cardiovascular diseases,with a view to providing new ideas for clinical intervention.

参考文献/References:

[1].Hashimoto C,Hudson KL,Anderson KV. The Toll gene of Drosophila,required for dorsal-ventral embryonic polarity,appears to encode a transmembrane protein[J]. Cell,1988,52(2):269-279.
[2].Medzhitov R,Preston-Hurlburt P,Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity[J]. Nature,1997, 388(6640):394-397.
[3].Kim AY,Shim HJ,Kim SY,et al. Differential regulation of MyD88- and TRIF-dependent signaling pathways of Toll-like receptors by cardamonin[J]. Int Immunopharmacol,2018,64:1-9.
[4].Balka KR,de Nardo D. Understanding early TLR signaling through the Myddosome[J]. J Leukoc Biol,2019,105(2):339-351.
[5].Jung WJ,Lee SY,Choi SI,et al. Toll-like receptor expression in pulmonary sensory neurons in the bleomycin-induced fibrosis model[J]. PLoS One,2018,3(13):e0193117.
[6].Yu L,Feng Z. The role of Toll-like receptor signaling in the progression of heart failure[J]. Mediators Inflamm,2018,2018,9874109.
[7].Kawai T,Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J].Immunity,2011,34(5):637-650.
[8].Griffin C,Eter L,Lanzetta N,et al. TLR4,TRIF,and MyD88 are essential for myelopoiesis and CD11c(+) adipose tissue macrophage production in obese mice[J]. J Biol Chem,2018,293(23):8775-8786.
[9].Takeda K,Akira S. Toll-like receptors[J]. Curr Protoc Immunol,2015,109:14.12.1-14.12.10.
[10].Zhang L,Zhang J,Jiang X,et al. Hydroxytyrosol Inhibits LPS-Induced Neuroinflammatory Responses via Suppression of TLR-4-Mediated NF-kappaB P65 Activation and ERK Signaling Pathway[J]. Neuroscience,2020,426:189-200.
[11].Pang Z,Junkins RD,Raudonis R,et al. Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways[J]. PLoS One,2018, 13(5):e0197491.
[12].Dai J,Gu L,Su Y,et al. Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-kappaB pathways[J]. Int Immunopharmacol,2018,54:177-187.
[13].Ullah MO,Sweet MJ,Mansell A,et al. TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target[J]. J Leukoc Biol,2016,100(1):27-45.
[14].Zhu Y,Li Q,Zhou Y,et al. TLR activation inhibits the osteogenic potential of human periodontal ligament stem cells through Akt signaling in a Myd88- or TRIF-dependent manner[J]. J Periodontol,2019,90(4):400-415.
[15].Yang Y,Lv J,Jiang S,et al. The emerging role of Toll-like receptor 4 in myocardial inflammation[J]. Cell Death Dis,2016,7(5):e2234.
[16].Li B,Xia Y,Hu B. Infection and atherosclerosis:TLR-dependent pathways[J]. Cell Mol Life Sci,2020,77(14):2751-2769.
[17].Jerez-Dolz D,Torramade-Moix S,Palomo M,et al. Internalization of microparticles by platelets is partially mediated by toll-like receptor 4 and enhances platelet thrombogenicity[J]. Atherosclerosis,2020,294:17-24.
[18].Karadimou G,Folkersen L,Berg M,et al. Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events[J]. Cardiovasc Res,2017,113(1):30-39.
[19].Fukuda D,Nishimoto S,Aini K,et al. Toll-like receptor 9 plays a pivotal role in angiotensin Ⅱ-induced atherosclerosis[J]. J Am Heart Assoc,2019,8(7): e010860.
[20].Rip J,de Bruijn MJW,Appelman MK,et al. Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease[J]. Front Immunol,2019,10:95.
[21].van Hout GP,Arslan F,Pasterkamp G,et al. Targeting danger-associated molecular patterns after myocardial infarction[J]. Expert Opin Ther Targets,2016,20(2):223-239.
[22].de Kleijn DPV,Chong SY,Wang X,et al. Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction[J]. Cardiovasc Res,2019,115(12):1791-1803.
[23].Liu FY,Fan D,Yang Z,et al. TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis[J]. Cell Death Dis,2019,10(7):480.
[24].Liu Y,Gao S,Wang Z,et al. Effect of stromal cell-derived factor-1 on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction[J]. Exp Ther Med,2016,12(5):3282-3286.
[25].Wang X,Ha T,Liu L,et al. TLR3 mediates repair and regeneration of damaged neonatal heart through Glycolysis dependent YAP1 regulated miR-152 expression[J]. Cell Death Differ,2018,25(5):966-982.
[26].van Golen RF,van Gulik TM,Heger M. The sterile immune response during hepatic ischemia/reperfusion[J]. Cytokine Growth Factor Rev,2012,23(3):69-84.
[27].Bonventre JV,Yang L. Cellular pathophysiology of ischemic acute kidney injury[J]. J Clin Invest,2011,121(11):4210-4221.
[28].Kalogeris T,Baines CP,Krenz M. Cell biology of ischemia/reperfusion injury[J]. Int Rev Cell Mol Biol ,2012,298:229-317.
[29].Feng Y,Chen H,Cai J,et al. Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling[J]. J Biol Chem,2015,290(44):26688-26698.
[30].Gollmann-Tepekoylu C,Graber M,Polzl L,et al. Toll-like receptor 3 mediates ischaemia/reperfusion injury after cardiac transplantation[J]. Eur J Cardiothorac Surg,2020,57(5):826-835.
[31].Parapanov R,Lugrin J,Rosenblatt-Velin N,et al. Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse[J]. Clin Sci(Lond),2015,129(2):187-198.
[32].Kitazume-Taneike R,Taneike M,Omiya S,et al. Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice[J]. Biochem Biophys Res Commun,2019,515(3):442-447.
[33].Rivadeneyra L,Charo N,Kviatcovsky D,et al. Role of neutrophils in CVB3 infection and viral myocarditis[J]. J Mol Cell Cardiol,2018,125:149-161.
[34].Fairweather D,Stafford KA,Sung YK. Update on coxsackievirus B3 myocarditis[J]. Curr Opin Rheumatol,2012,24(4):401-407.
[35].Tatsumi K,Schmedes CM,Houston ER,et al. Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection[J]. Cell Immunol,2019,344:103949.
[36].Liu T,Zhang M,Niu H,et al. Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-kappaB p65 signal pathway and protects mice from CVB3-induced virus myocarditis[J]. Int J Biol Macromol,2019,126:179-186.
[37].Fuse K,Chan G,Liu Y,et al. Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production[J]. Circulation,2005,112(15):2276-2285.
[38].Baxan N,Papanikolaou A,Salles-Crawley I ,et al. Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging[J]. Dis Model Mech,2019,12(8):dmm040725.
[39].Oka T,Hikoso S,Yamaguchi O ,et al. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure[J]. Nature,2012,485(7397):251-255.
[40].Becher PM,Hinrichs S,Fluschnik N,et al. Role of Toll-like receptors and interferon regulatory factors in different experimental heart failure models of diverse etiology:IRF7 as novel cardiovascular stress-inducible factor[J]. PLoS One,2018,13(3):e0193844.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(重点项目)(81530012);国家重点研发计划资助项目(2018YFC1311300);国家卫生计生委医药卫生科技发展研究中心资助项目(2016ZX-008-01);中央高校基本科研业务费专项资金(2042018kf1032);武汉市科技计划项目(2018061005132295) 通信作者:唐其柱,E-mail: qztang@whu.edu.cn 收稿日期:2020-12-08
更新日期/Last Update: 2021-09-26