[1]赵霄潇 郭文钦 王莹 颜红兵.升高的肌钙蛋白水平对行急诊PCI的急性心肌梗死患者预后价值的荟萃分析[J].心血管病学进展,2021,(9):838-844.[doi:10.16806/j.cnki.issn.1004-3934.2021.09.000]
 ZHAO XiaoxiaoGUO Wenqin,WANG Ying,YAN Hongbing.a Meta-Analysis of Prognostic Value of Elevated Troponin Levels in Patients with Acute Myocardial Infarction Undergoing Primary PCI[J].Advances in Cardiovascular Diseases,2021,(9):838-844.[doi:10.16806/j.cnki.issn.1004-3934.2021.09.000]
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升高的肌钙蛋白水平对行急诊PCI的急性心肌梗死患者预后价值的荟萃分析()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年9期
页码:
838-844
栏目:
论著
出版日期:
2021-09-25

文章信息/Info

Title:
a Meta-Analysis of Prognostic Value of Elevated Troponin Levels in Patients with Acute Myocardial Infarction Undergoing Primary PCI
文章编号:
202004072
作者:
赵霄潇1 郭文钦 2 王莹1 颜红兵12
(1.中国医学科学院阜外心血管病医院,北京 100037;2.中国医学科学院阜外医院深圳医院,深圳 518000)
Author(s):
ZHAO Xiaoxiao1GUO Wenqin2WANG Ying1YAN Hongbing 12
(1.Fuwai Hospital,National Center for Cardiovascular Diseases,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100037China 2.Fuwai Hospital,Chinese Academy of Medical Sciences,Shenzhen 518000China)?/html>
关键词:
肌钙蛋白预后随访荟萃分析
Keywords:
TroponinPrognosisFollow-upMeta-analysis
DOI:
10.16806/j.cnki.issn.1004-3934.2021.09.000
摘要:
目的 通过荟萃分析研究肌钙蛋白T和肌钙蛋白I水平对急诊经皮冠状动脉介入治疗的急性心肌梗死患者的近期及远期预后价值。 方法 通过计算机检索Medline、Pubmed和Embase数据库,检索年限为2008—2019年。由研究者按Cochrane系统评价方法,进行筛选、评价质量及资料提取,使用Stata 11.0软件进行荟萃、发 表偏倚及敏感性分析等。结果 共纳入9篇研究,总计6 162人,荟萃分析结果显示肌钙蛋白T和肌钙蛋白I水平升高均与预后事件的风险增加有关(肌钙蛋白I: HR=1.02, 95% CI 1.00~1.05, P<0.001; 肌钙蛋白T:HR=1.07, 95% CI 1.07~1.08 , P=0.004); 并且对于长期预后提示为危险因素(HR=1.08, 95% CI 1.03~1.14);升高的肌钙蛋白的基线( HR =1.46,95% CI 1.13~1.88)和峰值水平( HR =1.08,95% CI 1.03~1.13)均为经随访的临床终点事件的危险因素。Begg’s检验和Egger’s检验表明无发表偏倚。敏感性分析显示本次荟萃分析结果稳定性较好。 结论 对于行急 诊经皮冠状动脉介入治疗的急性心肌梗死患者,升高的肌钙蛋白的基线和峰值水平与预后不良有关,并且对24个月以上的长期不良预后具有更显著的相关性。
Abstract:
Objective The aim of this investigation was to detect the short-term and long-term prognostic value of troponin T and troponin I levels in patients with acute myocardial infarction undergoing primary percuta neous coronary intervention by meta-analysis. Methods Medline,Pubmed and Embase databases were searched by computer from 2008 to 2019. Chchrane system evaluation method was used by researchers to screen,evaluate quality and extract data. Stata 11.0 software was used for meta-analysis,publication bias and sensitivity analysis. Results A total of 6 162 adults were included in 9 studies. The results of meta-analysis showed that both troponin T and troponin I were associated with an increased risk of prognostic events(troponin I:HR=1.02,95% CI 1.00 ~1.05, P<0.001;troponin T:HR=1.07, 95% CI 1.07 ~1.08, P=0.004). In addition, the long-term prognosis was a risk factor(HR=1.08, 95% CI 1.03 ~1.14). Baseline(HR=1.46, 95% CI 1.13 ~1.88) and peak level (HR=1.08, 95% CI 1.03 ~1.13) of elevated troponin were risk factors for clinical endpoint events at follow-up.Begg’s test and Egger’s test did not showd the bias of publication. Sensitivity analysis showed that the results of this meta-analysis were stable. Conclusion I n patients with acute myocardial infarction undergoing primary percutaneous coronary intervention, elevated baseline and peak troponin levels were associated with poor prognosis,and were more significantly correlated with long-term poor prognosis over 24 months.

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更新日期/Last Update: 2021-10-21