[1]陈焕,综述,邓平,等.S100A1蛋白基因治疗心力衰竭的研究进展[J].心血管病学进展,2016,(3):302-305.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.023]
 CHEN Huan,DENG Ping.Research Progress in S100A1 Gene Therapy for Heart Failure[J].Advances in Cardiovascular Diseases,2016,(3):302-305.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.023]
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S100A1蛋白基因治疗心力衰竭的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
302-305
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
Research Progress in S100A1 Gene Therapy for Heart Failure
作者:
陈焕12综述邓平2审校
1.南华大学,湖南 衡阳 421001; 2.长沙市中心医院心内科,湖南 长沙 410004
Author(s):
CHEN Huan12DENG Ping2
1.University of South China,Hengyang 421001,Hunan,China; 2.Department of Cardiology,Changsha Central Hospital,Changsha 421004,Hunan,China
关键词:
S100A1蛋白 心力衰竭 基因治疗R394
Keywords:
S100A1 Heart failure Gene therapy
分类号:
R541.6+1
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.023
文献标志码:
A
摘要:
心力衰竭是各种心脏疾病发展的终末阶段。S100A1蛋白高度特异性表达于心肌细胞,在心力衰竭时,其表达明显降低。S100A1蛋白可具有抑制心肌程序性细胞死亡、逆转心肌重构、改善心肌细胞能量供应及增强心肌细胞收缩力的作用。近年来,许多研究发现S100A1蛋白高表达可用于治疗心力衰竭。
Abstract:
Heart failure is the common endpoint of various cardiovascular diseases. S100A1 is abundantly present in normal human myocardial tissue,and its expression levels are diminished in failing myocardium. S100A1 protein can induce cardiomyocyte apoptosis, reverse myocardial remodeling,improve energy homeostasis and increase both systolic and diastolic cardiac function. In recent years, many studies have found that S100A1 over-expression in cardiomyocytes can be used in the treatment of heart failure.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:陈焕(1991— ),在读硕士,主要从事心力衰竭研究。Email: 947994139@ qq. com 通信作者:邓平( 1968—),主任医师,博士,硕士导师,主要从事心血管疾病研究。Email: 1229015862@ qq. Com
更新日期/Last Update: 2016-05-25