[1]吴春 罗玉梅.体育锻炼调控微RNA改善急性心肌梗死后心脏康复机制的研究进展[J].心血管病学进展,2026,(1):58.[doi:10.16806/j.cnki.issn.1004-3934.2026.01.012]
　WU Chun,LUO Yumei.Advances in Mechanisms of Physical Exercise-Mediated MicroRNA Regulation in Cardiac Rehabilitation after Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2026,(1):58.[doi:10.16806/j.cnki.issn.1004-3934.2026.01.012]
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体育锻炼调控微RNA改善急性心肌梗死后心脏康复机制的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2026年1期
页码:
58
栏目:
综述
出版日期:
2026-01-25

文章信息/Info

Title:
Advances in Mechanisms of Physical Exercise-Mediated MicroRNA Regulation in Cardiac Rehabilitation after Acute Myocardial Infarction
作者:
吴春1; 2 罗玉梅 1; 2
(1.广东医科大学,广东 湛江 524023;2.深圳市龙岗区人民医院,广东 深圳 518172)
Author(s):
WU Chun 1; 2; LUO Yumei 1; 2
(1.Guangdong Medical University ,Zhanjiang 524023,Guangdong,China2.Shenzhen Longgang District People’s Hospital,Shenzhen 518172,Guangdong,China)
关键词:
心肌细胞; 急性心肌梗死; 体育锻炼; 微RNA; 心血管疾病
Keywords:
Cardiomyocyte; Acute?myocardial?infarction; Physical?exercise; MicroRNA
DOI:
10.16806/j.cnki.issn.1004-3934.2026.01.012
摘要:
微RNA（miRNA）在心血管疾病的病理生理过程中具有潜力，可作为诊断标志物和治疗靶点。急性心肌梗死作为全球的主要致死病因，其病理改变可通过非药物干预策略——体育锻炼得到改善。体育锻炼通过调控miRNA信号（如miR-222、miR-1192、miR-146、miR-126等），调节心肌细胞基因表达、增强抗凋亡能力、优化自噬、减轻纤维化与肥大、促进血管新生。现主要综述体育锻炼调控miRNA改善急性心肌梗死后心脏康复的分子机制，为开发靶向治疗策略和运动康复方案提供理论依据。未来需深化抗阻训练的作用机制研究，并推动实验成果向临床转化。
Abstract:
MicroRNA (miRNA) represents promising diagnostic and therapeutic targets in the pathophysiology of cardiovascular diseases. As the primary global cause of cardiovascular diseases-related mortality ,acute myocardial infarction demonstrates pathological alterations that can be ameliorated through physical exercise,a non-pharmacological intervention strategy. miRNA serves as biomarkers for acute myocardial infarction diagnosis ,while physical exercise modulates miRNA signaling pathways (including miR-222,miR-1192,miR-146,and miR-126, among others.) to regulate cardiomyocye gene expression,enhance anti-apoptotic capacity,improve autophagic flux,attenuate fibrosis and hypertrophy,and promote angiogenesis. This review synthesizes molecular mechanisms through which physical exercise-regulated miRNA facilitates post- acute myocardial infarction cardiac repair ,establishing a theoretical framework for developing targeted therapies and exercise-based rehabilitation. Future investigations should further elucidate the mechanisms of resistance training and translate experimental findings into clinical applications

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更新日期/Last Update: 2026-05-14