[1]董超 戴红艳.胰岛素抵抗与左心衰竭相关性肺动脉高压的研究进展[J].心血管病学进展,2026,(1):33.[doi:10.16806/j.cnki.issn.1004-3934.2026.01.007]
 DONG Chao,DAI Hongyan.Insulin Resistance and Pulmonary Hypertension Associated with Left Heart Failure[J].Advances in Cardiovascular Diseases,2026,(1):33.[doi:10.16806/j.cnki.issn.1004-3934.2026.01.007]
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胰岛素抵抗与左心衰竭相关性肺动脉高压的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2026年1期
页码:
33
栏目:
综述
出版日期:
2026-01-25

文章信息/Info

Title:
Insulin Resistance and Pulmonary Hypertension Associated with Left Heart Failure
作者:
董超1 戴红艳2
(1.山东第二医科大学临床医学院,山东 潍坊 261053;2.康复大学青岛医院 青岛市市立医院东院区心内保健科,山东 青岛 266000)
Author(s):
DONG Chao1DAI Hongyan2
(1. School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,Shandong,China; 2. Department of Cardiac Health,East Hospital of Qingdao Municipal Hospital,Qingdao Hospital of Rehabilitation University,Qingdao 266000,Shandong,China)
关键词:
左心衰竭相关性肺动脉高压胰岛素抵抗胰岛素信号通路氧化应激炎症反应
Keywords:
Pulmonary hypertension associated with left heart failureInsulin resistanceInsulin signaling pathwayOxidative stressInflammatory reaction
DOI:
10.16806/j.cnki.issn.1004-3934.2026.01.007
摘要:
左心衰竭相关性肺动脉高压(PH-LHF)是2型肺动脉高压的重要亚类,可发生在不同类型的心力衰竭,尤其是射血分数保留的心力衰竭。胰岛素抵抗(IR)作为多种心血管疾病的独立危险因素,与肺动脉高压的发生和发展亦存在密切关联。研究表明,IR所引起的肺血管紧张性增加、血管内皮功能受损以及肺血管重塑等多种病理改变可能参与PH-LHF的发生和发展。现主要对进行综述以期为
Abstract:
Pulmonary hypertension associated with left heart failure(PH-LHF) is a significant subtype of type 2 pulmonary hypertension that can occur in different types of heart failure,particularly heart failure with preserved ejection fraction. As an independent risk factor for a variety of cardiovascular diseases,insulin resistance(IR) is closely related to the occurrence and development of pulmonary hypertension. Studies have shown that a variety of pathological changes caused by IR,such as increased pulmonary vascular tension,impaired vascular endothelial function,and pulmonary vascular remodeling,may be involved in the occurrence and development of PH-LHF. In this article,we mainly review the research status of IR and PH-LHF,in order to find new therapeutic targets for PH-LHF

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更新日期/Last Update: 2026-05-14