[1]柯晓琴 王霆 董翔宇 童永幅 冯艳 申良红 王凤霞.老年营养风险指数与冠状动脉慢性完全闭塞合并射血分数保留的心力衰竭患者发生不良心血管事件的相关性研究[J].心血管病学进展,2026,(1):83.[doi:10.16806/j.cnki.issn.1004-3934.2026.01.016]
　KE Xiaoqin?WANG Ting?DONG Xiangyu?TONG Yongfu?FENG Yan?,SHEN Lianghong?,WANG Fengxia?/html>.Geriatric Nutritional Risk Index in Elderly with Occurrence of Adverse Cardiovascular Events in Patients with Chronic Total Occlusion Combined with Heart Failure with Preserved Ejection Fraction[J].Advances in Cardiovascular Diseases,2026,(1):83.[doi:10.16806/j.cnki.issn.1004-3934.2026.01.016]
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老年营养风险指数与冠状动脉慢性完全闭塞合并射血分数保留的心力衰竭患者发生不良心血管事件的相关性研究()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2026年1期
页码:
83
栏目:
论著
出版日期:
2026-01-25

文章信息/Info

Title:
Geriatric Nutritional Risk Index in Elderly with Occurrence of Adverse Cardiovascular Events in Patients with Chronic Total Occlusion Combined with Heart Failure with Preserved Ejection Fraction
作者:
柯晓琴1 王霆1 董翔宇1 童永幅1 冯艳2 申良红3 王凤霞1
（1.新疆维吾尔自治区人民医院心脏及泛血管医学诊疗中心 心内科，新疆 乌鲁木齐 830000；2. 新疆维吾尔自治区人民医院心脏及泛血管医学诊疗中心 心电学科，新疆 乌鲁木齐 830000；3. 新疆维吾尔自治区人民医院急救中心，新疆 乌鲁木齐 830000）
Author(s):
KE Xiaoqin?WANG Ting?DONG Xiangyu?TONG Yongfu?FENG Yan?; SHEN Lianghong?; WANG Fengxia?/html>
(1.Center for Cardiac and Pan-Vascular Medicine Diagnosis and Treatment,Department of Cardiology,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang ,China2. Center for Cardiac and Pan-Vascular Medicine Diagnosis and Treatment,Department of Electrocardiology,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang,China3. Emergency Center,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang,China)
关键词:
老年营养风险指数; 冠状动脉慢性完全闭塞; 血分数保留的心力衰竭; 主要不良心血管事件
Keywords:
Geriatric nutritional risk index; Chronic total occlusion; Heart failure with preserved ejection fraction; Major adverse cardiovascular event
DOI:
10.16806/j.cnki.issn.1004-3934.2026.01.016
摘要:
目的?#160探讨老年营养风险指数(GNRI)与冠状动脉慢性完全闭塞 (CTO)（HFpEF）患者发生主要不良心血事件（MACE）的关系。方法?选取2013年6月至2023年10月就诊于并为CTO的老年患者（年龄65岁）例作为研究对象收集患者的基线数据，采用GNRI对进行营养风险评估为GNRI正常组（GNRI＞98，n=）与GNRI降低组（GNRI98，n=），探究其与CTO及之间的关系。结果?两组基线特征显示，与GNRI降低组相比，GNRI正常组的MACE明显降低0.001。Kaplan?Meier生存分析发现，GNRI（P）。Cox回归分析发现GNRI在BMI≥28 kg/m2、无吸烟史、有糖尿病史、有高血压病史、无心律失常病史、无既往病史及有多支病变亚组与MACE的发生显著相关（P0.001）。ROC曲线显示，。结论?GNRI与CTO合并之间存在相关性，GNRI可预测CTO患者发生MACE的标志物。
Abstract:
Objective??/b>Investigating the relationship between the geriatric nutritional risk index (GNRI) and the occurrence of major adverse cardiovascular event (MACE) in patients with chronic total occlusion (CTO) combined with heart failure with preserved ejection fraction (HFpEF). Methods??/b>A total of 185 elderly patients (aged≥65 years) diagnosed with CTO combined with HFpEF who were admitted to People’s Hospital of Xinjiang Uygur Autonomous Region between June 2013 and October 2023 were selected as study subjects. Baseline data were collected for patients. Nutritional risk assessment was performed using GNRI, categorizing patients into the GNRI normal group (GNRI＞98, n=94) and the GNRI reduced group (GNRI≤98,n=91) to explore the relationship between GNRI and CTO with HFpEF, as well as its impact on prognosis. Results?#160Baseline characteristics showed that the incidence of MACE was significantly lower in the GNRI normal group compared with the GNRI reduced group (P＜0.001). Kaplan-Meier survival analysis revealed that the cumulative survival rate without MACE was lower in the GNRI reduced group (P=0.003). Cox regression analysis identified normal GNRI, history of previous myocardial infarction, and fasting blood glucose level as independent risk factors for MACE occurrence. Subgroup analysis indicated that GNRI remained significantly associated with MACE occurrence in subgroups with BMI≥28 kg/m2,no smoking history, history of diabetes, history of hypertension, no history of arrhythmia, no history of previous myocardial infarction, and multiple vessel disease (P＜0.001). The restricted cubic spline curve showed a linear correlation between GNRI and MACE occurrence (P for nonlinear=0.057). The ROC curve showed the AUC was 0.794,0.725,and 0.841 at 3,5,and 8 years, respectively. A line chart was used to visualize the predicted risk of MACE occurrence in patients. Conclusion?#160There is a correlation between GNRI and CTO combined with HFpEF. GNRI can serve as a biomarker for predicting the occurrence of MACE in patients with CTO combined with HFpEF, thereby assisting healthcare professionals in identifying high-risk patients and providing appropriate nutritional support to reduce adverse outcomes

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更新日期/Last Update: 2026-05-14