[1]杨安妮 厉腊梅 周桐 范新宇 蔡高军.纤维蛋白原/白蛋白比值与早发冠心病的相关性研究[J].心血管病学进展,2025,(9):850.[doi:10.16806/j.cnki.issn.1004-3934.2025.09.018]
　YANG Anni,LI Lamei,ZHOU Tong,et al.A Study on Correlation Between Fibrinogen/Albumin Ratio And Premature Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2025,(9):850.[doi:10.16806/j.cnki.issn.1004-3934.2025.09.018]
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纤维蛋白原/白蛋白比值与早发冠心病的相关性研究()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年9期
页码:
850
栏目:
论著
出版日期:
2025-09-25

文章信息/Info

Title:
A Study on Correlation Between Fibrinogen/Albumin Ratio And Premature Coronary Heart Disease
作者:
杨安妮 厉腊梅 周桐 范新宇 蔡高军
(江苏大学附属武进医院 徐州医科大学附属武进临床医院心内科,江苏 常州 213017)
Author(s):
YANG Anni; LI Lamei; ZHOU Tong; FAN Xinyu; CAI Gaojun
(Department of Cardiology,Wujin Hospital Affiliated with Jiangsu University ,The Wujin Clinical College of Xuzhou Medical University,Changzhou 213017,Jiangsu,China)
关键词:
早发冠心病; 纤维蛋白原/白蛋白比值; 性别; 横断面研究
Keywords:
Premature coronary heart disease; Fibrinogen/albumin ratio; Gender; Cross-sectional study
DOI:
10.16806/j.cnki.issn.1004-3934.2025.09.018
摘要:
目的 探讨纤维蛋白原与白蛋白比值（FAR）与早发冠心病（PCHD）之间的关系。方法 本研究连续纳入接受冠状动脉造影的患者（男性年龄＜55岁，女性年龄＜65岁），将患者分为PCHD组和对照组。比较两组患者的临床数据，通过logistic回归分析FAR与PCHD之间的关系。结果 本研究共纳入1 897例患者，其中男性956例，PCHD组1 165例。PCHD组FAR值0.07（0.06，0.08）显著高于对照组0.06（0.05，0.07）（P＜0.001）。多因素logistic回归分析显示FAR作为连续变量和分类变量是PCHD的独立相关因素（OR=2.467，95% CI 1.635～3.722，P＜0.001；OR=1.667，95% CI 1.287～2.160，P＜0.001）；且随着FAR值升高，与PCHD发生风险的相关性也逐渐增加，FAR高值组发生PCHD风险的相关性为FAR低值组的1.667倍。性别亚组分析显示，FAR与女性PCHD风险呈显著正相关（OR=1.677，95% CI 1.177～2.389，P=0.004）。结论 FAR是PCHD发生风险的独立相关因素。
Abstract:
Objective To investigate the association between fibrinogen/albumin ratio (FAR) and premature coronary heart disease (PCHD). Methods Consecutive enrollment of patients undergoing coronary angiography (aged＜55 years for males and aged＜65 years for females) was conducted. Participants were stratified into PCHD group and control group. The clinical data of patients in the two groups were compared ,followed by logistic regression analyses to determine the relationship between FAR and PCHD. Results Among 1 897 enrolled participants,including 956 males,1 165 were classified into the PCHD group. Significantly elevated FAR levels were observed in the PCHD group compared to control group [0.07（0.06,0.08）vs 0.06（0.05,0.07），P＜0.001]. Multivariate logistic regression analysis demonstrated that FAR,as both a continuous variable（OR=2.467，95% CI 1.635～3.722，P＜0.001）and a categorical variable（OR=1.667，95% CI 1.287～2.160，P＜0.001）,was an independent correlate of PCHD. Furthermore,the correlation with PCHD increased progressively with increasing FAR values. Compared with the low-FAR group ,the high-FAR group exhibited a 1.667-fold increase in the levels associated with PCHD. Subgroup analysis by gender revealed a significant positive correlation between FAR and PCHD risk in females（OR=1.677，95% CI 1.177～2.389，P=0.004）. Conclusion The FAR was identified as an independent associated factor for the risk of PCHD occurrence

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更新日期/Last Update: 2025-12-18