[1]朱金澳 陈沙沙 胡朗 王瑛 郭艳杰.HADHA的乙酰化修饰在心血管疾病中的作用研究进展[J].心血管病学进展,2025,(10):906.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.010]
 ZHU Jinao,CHEN Shasha,HU Lang,et al.Research Progress on the Role of HADHA?cetylation Modification in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2025,(10):906.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.010]
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HADHA的乙酰化修饰在心血管疾病中的作用研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年10期
页码:
906
栏目:
综述
出版日期:
2025-10-25

文章信息/Info

Title:
Research Progress on the Role of HADHA?cetylation Modification in Cardiovascular Diseases
作者:
朱金澳1 陈沙沙 1 胡朗 2 王瑛 2 郭艳杰 3
(1.陕西中医药大学,陕西 咸阳 712046;2.空军军医大学第二附属医院,陕西 西安 710038;3.西安国际医学中心心内科,陕西 西安 710100)
Author(s):
ZHU Jinao1CHEN Shasha1HU Lang2WANG Ying2GUO Yanjie3
?1Shaanxi University of Chinese MedicineXianyang 712046ShaanxiChina2.The Second Affiliated Hospital of Air Force Medical UniversityXian 710038ShaanxiChina3.Department of CardiologyXian International Medical Center HospitalXian 710100ShaanxiChina)
关键词:
羟酰辅酶A脱氢酶三功能多酶复合物亚基α乙酰化修饰心肌能量代谢炎症小体心血管疾病
Keywords:
Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit Acetylation modificationMyocardial energy metabolismInflammasomeCardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2025.10.010
摘要:
心血管疾病是全球发病率和死亡率最高的疾病之一,其发病机制与心肌能量代谢异常及炎症反应密切相关。羟酰辅酶A脱氢酶三功能多酶复合物亚基α(HADHA)作为脂肪酸β氧化的关键酶,在心肌能量稳态中发挥重要作用。近年研究发现,HADHA的乙酰化修饰通过影响其酶活性和稳定性,调控心肌能量代谢和炎症反应,成为心血管疾病研究的热点。其中组蛋白脱乙酰酶3、沉默信息调节因子2相关酶类3和一般控制不可抑制5样蛋白1(GCN5L1)等通过调节HADHA乙酰化状态,影响脂肪酸氧化和炎症反应。因此,调控HADHA乙酰化水平可能成为心血管疾病的新策略。现综述最新的研究进展,总结HADHA的乙酰化修饰在心血管疾病中发挥作用的机制。
Abstract:
Cardiovascular diseases are among the leading causes of global morbidity and mortality,with its pathogenesis closely linked to abnormal myocardial energy metabolism and inflammatory responses. Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit α(HADHA),a key enzyme in fatty acid β-oxidation,plays a critical role in maintaining myocardial energy homeostasis. Recent studies have revealed that HADHA acetylation modulates myocardial energy metabolism and inflammatory responses by regulating its enzymatic activity and stability,making it a hotspot in cardiovascular research. Notably,HDAC3,SIRT3,and GCN5L1 influence fatty acid oxidation and inflammatory responses by modulating the acetylation status of HADHA. Therefore,targeting HADHA acetylation may emerge as a novel therapeutic strategy for cardiovascular diseases. This review summarizes the latest research progress and elucidates the mechanisms by which HADHA acetylation contributes to cardiovascular diseases.

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更新日期/Last Update: 2026-01-16