[1]刘克杰 高渊博 赵思玉 王一鸣 王好 陶艾彬.Cx43在心房颤动中的研究进展[J].心血管病学进展,2025,(10):922.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.013]
　LIU Kejie,GAO Yuanbo,ZHAO Siyu,et al.Connexin 43 in Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2025,(10):922.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.013]
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Cx43在心房颤动中的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年10期
页码:
922
栏目:
综述
出版日期:
2025-10-25

文章信息/Info

Title:
Connexin 43 in Atrial Fibrillation
作者:
刘克杰 高渊博 赵思玉 王一鸣 王好 陶艾彬
(江苏大学附属人民医院,江苏 镇江 212002)
Author(s):
LIU Kejie ; GAO Yuanbo ; ZHAO Siyu ; WANG Yiming ; WANG Hao ; TAO Aibin
(The People’s Hospital Affiliated of Jiangsu University ,Zhenjiang212002,Jiangsu,China)
关键词:
间隙连接蛋白43; 翻译后修饰; 心房颤动; 电重构; 结构重构; 治疗策略
Keywords:
Connexin43; Post-translational modifications; Atrial fibrillation; Electrical remodeling; Structural remodeling; Therapeutic strategies
DOI:
10.16806/j.cnki.issn.1004-3934.2025.10.013
摘要:
心房颤动（AF）是最常见的心律失常，涉及心脏电生理异常，并与多种心血管疾病的病理进程相互影响。近年来，间隙连接蛋白43（Cx43）作为形成心肌细胞间缝隙连接通道的核心蛋白，被证实与AF的发生及持续存在显著关联。本综述阐述了Cx43在AF中的多重作用机制，重点探讨其翻译后修饰特点、调控心房电生理功能紊乱及纤维化重构的分子基础，并深入分析与Cx43相关的AF治疗策略。通过总结Cx43与AF的作用关系，旨在为AF病理生理机制的理解和其精准治疗策略的开发提供新视角。
Abstract:
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia,characterized by abnormal cardiac electrophysiology and its interaction with the pathophysiological processes of various cardiovascular diseases. In recent years,connexin43 (Cx43),as a core protein forming gap junction channels between cardiomyocytes,has been identified as significantly associated with the initiation,maintenance,and progression of AF. This review systematically elucidates the multifaceted mechanisms of Cx43 in AF,with an emphasis on its post-translational modifications,the molecular underpinnings of atrial electrophysiological dysfunction and fibrotic remodeling,and provides an in-depth analysis of AF treatment strategies targeting Cx43. By synthesizing the current understanding of the relationship between Cx43 and AF,this review aims to offer novel insights into the pathophysiological mechanisms underlying AF and facilitate the development of precise therapeutic interventions

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更新日期/Last Update: 2026-01-16