[1]杨婧如 郁志明.TRAP1在促进血管平滑肌细胞衰老和动脉粥样硬化中的研究进展[J].心血管病学进展,2025,(10):917.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.012]
 YANG Jingru,YU Zhiming.TRAP1 in promoting aging and atherosclerosis of vascular smooth muscle cells[J].Advances in Cardiovascular Diseases,2025,(10):917.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.012]
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TRAP1在促进血管平滑肌细胞衰老和动脉粥样硬化中的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年10期
页码:
917
栏目:
综述
出版日期:
2025-10-25

文章信息/Info

Title:
TRAP1 in promoting aging and atherosclerosis of vascular smooth muscle cells
作者:
杨婧如 郁志明
(南京医科大学附属无锡市人民医院心血管内科,江苏 无锡 214023)
Author(s):
YANG JingruYU Zhiming
(Department of Cardiovascular MedicineThe Affiliated Wuxi Peoples Hospital of Nanjing Medical UniversityWuxi 214023,Jiangsu,China) [
关键词:
肿瘤坏死因子受体相关蛋白1血管平滑肌细胞衰老动脉粥样硬化
Keywords:
TNF receptor-associated protein 1Vascular smooth muscleCell senescenceAtherosclerosis
DOI:
10.16806/j.cnki.issn.1004-3934.2025.10.012
摘要:
血管平滑肌细胞衰老对动脉粥样硬化的发生发展至关重要。肿瘤坏死因子受体相关蛋白1(TRAP1)作为热休克蛋白90家族中重要的线粒体蛋白,与细胞衰老相关。TRAP1的表观遗传调控和代谢重编程促进血管平滑肌细胞衰老,进而加速动脉粥样硬化的进程。文章就TRAP1对血管平滑肌细胞衰老和动脉粥样硬化的影响进行综述,旨在为动脉粥样硬化的靶向治疗提供新的思路。
Abstract:
Vascular smooth muscle cell senescence is essential for the initiation and progression of atherosclerosis. TNF receptor-associated protein 1(TRAP1 )is an important mitochondrial protein in the heat shock protein 90 family and is associated with cellular senescence. The epigenetic regulation and metabolic reprogramming of TRAP1 promote vascular smooth muscle cell senescence,thereby accelerating the process of atherosclerosis. This article reviews the roles of TRAP1 on vascular smooth muscle cell senescence and atherosclerosis,aiming to provide new ideas for targeted therapy of atherosclerosis

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更新日期/Last Update: 2026-01-16