[1]陈燕亭 李可心.SOX18表达与钙化性主动脉瓣膜疾病的相关性研究[J].心血管病学进展,2025,(11):1032.[doi:10.16806/j.cnki.issn.1004-3934.2025.11.015]
　CHEN Yanting,LI Kexin.The Correlation Between SOX18 Expression and Calcific Aortic Valve Disease[J].Advances in Cardiovascular Diseases,2025,(11):1032.[doi:10.16806/j.cnki.issn.1004-3934.2025.11.015]
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SOX18表达与钙化性主动脉瓣膜疾病的相关性研究()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年11期
页码:
1032
栏目:
论著
出版日期:
2025-11-25

文章信息/Info

Title:
The Correlation Between SOX18 Expression and Calcific Aortic Valve Disease
作者:
陈燕亭 李可心
(中山大学附属第五医院病理科,广东 珠海 519000)
Author(s):
CHEN Yanting ;  LI Kexin
(Department of Pathology,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,Guangdong,China)
关键词:
钙化性主动脉瓣膜疾病; 间质细胞; 性别决定区Y框蛋白18; 炎症; 血管内皮生长因子D
Keywords:
Calcific aortic valve disease; Interstitial cell; Sex-determining region Y-box 18 ; Inflammation; Vascular endothelial growth factor D
DOI:
10.16806/j.cnki.issn.1004-3934.2025.11.015
摘要:
目的 探究钙化性主动脉瓣膜疾病中性别决定区Y框蛋白18（SOX18）的作用。 方法 连续收集2020—2024年于中山大学附属第五医院行主动脉瓣膜置换术患者的瓣膜标本67例，所有患者瓣膜均完成茜素红S染色及钙化评估，根据瓣膜钙化程度分为对照组和钙化组（轻度及重度钙化）。在组织水平上，通过免疫组织化学方法检测主动脉瓣膜中SOX18的表达位置和水平，并对比表达差异。 结果 SOX18阳性表达定位于主动脉瓣膜间质细胞核。钙化组中SOX18表达显著高于对照组，差异具有统计学意义（P＜0.05）。钙化性主动脉瓣膜疾病患者中SOX18表达增加与CD68和血管内皮生长因子D呈正相关。 结论 SOX18在钙化性主动脉瓣膜间质细胞中高表达，可能通过促进血管生成及增加炎症浸润来参与钙化。
Abstract:
Objective To investigate the role of sex-determining region Y-box 18( SOX18) in calcific aortic valve disease(CAVD). Methods We collected 67 aortic valve specimens from patients who underwent aortic valve replacement at The Fifth Affiliated Hospital of Sun Yat-sen University between 2020 and 2024. All valve samples were assessed for calcification using alizarin red S staining and categorized into control and calcification groups(mild and severe calcification) based on the degree of valve calcification. At the tissue level,immunohistochemistry was performed to determine the expression localization and level of SOX18,and the expression differences were compared. Results SOX18-positive expression was localized in the aortic valve interstitial cell. The calcification group exhibited significantly higher SOX18 expression than the control group,with a statistically significant difference(P<0.05). In patients with CAVD,elevated SOX18 expression shows positive correlations with both CD68 and vascular endothelial growth factor D . Conclusion SOX18 is highly expressed in calcified aortic valve interstitial cells and may participate in calcification by promoting angiogenesis and increasing inflammatory infiltration.

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更新日期/Last Update: 2026-03-06