[1]李龙 国伟.SHH信号通路与心肌梗死后血管再生的研究进展[J].心血管病学进展,2025,(10):912.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.011]
 LI Long,GUO Wei.SHH Signaling Pathway and Vascular Regeneration after Myocardial Infarction[J].Advances in Cardiovascular Diseases,2025,(10):912.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.011]
点击复制

SHH信号通路与心肌梗死后血管再生的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年10期
页码:
912
栏目:
综述
出版日期:
2025-10-25

文章信息/Info

Title:
SHH Signaling Pathway and Vascular Regeneration after Myocardial Infarction
作者:
李龙1 国伟2
(1.济宁医学院临床医学院,山东 济宁,272000;2.济宁市第一人民医院老年医学科,山东 济宁,272000)
Author(s):
LI Long1GUO Wei2
(1.Clinical Medicine College of Jining Medical UniversityJining 272000ShandongChina2.Department of Geriatrics,Jining First People’s HospitalJining 272000ShandongChina)
关键词:
心肌梗死SHH信号通路血管再生
Keywords:
Myocardial infarctionSonic Hedgehog signaling pathwayVascular regeneration
DOI:
10.16806/j.cnki.issn.1004-3934.2025.10.011
摘要:
Sonic Hedgehog(SHH)信号通路,作为调控胚胎发育和组织稳态的重要途径,近年来被发现通过多种机制参与心肌梗死后血管的再生过程。本文系统性地回顾了SHH通路的核心分子机制及其在血管再生中的作用。这些发现为未来针对心肌梗死后血管再生的精准干预提供了潜在的靶点。
Abstract:
The Sonic Hedgehog (SHH) signaling pathway,a key regulator of embryonic development and tissue homeostasis,has been found to participate in post-myocardial infarction vascular regeneration through multiple mechanisms. This article systematically reviews the core molecular mechanisms of the SHH pathway and its role in angiogenesis. These findings provide potential therapeutic targets for precise interventions aimed at enhancing vascular regeneration after myocardial infarction

参考文献/References:

[1].Wu X,Reboll MR,Korf-Klingebiel M,et al. Angiogenesis after acute myocardial infarction[J].?Cardiovasc Res,2021,117(5):1257-1273.
[2].Ingham PW. Hedgehog signaling[J]. Curr Top Dev Biol,2022,149:1-58.
[3].Garg C,Khan H,Kaur A,et al. Therapeutic implications of Sonic Hedgehog pathway in metabolic disorders:novel target for effective treatment[J]. Pharmacol Res,2022,179:106194.
[4].Jeng KS,Chang CF,Lin SS. Sonic Hedgehog signaling in organogenesis,tumors,and tumor microenvironments[J]. Int J Mol Sci,2020,21(3):758.
[5].Zhang Y,Beachy PA. Cellular and molecular mechanisms of Hedgehog signalling[J]. Nat Rev Mol Cell Biol,2023,24(9):668-687.
[6].Cadena Del Castillo CE,Hannich JT,Kaech A,et al. Patched regulates lipid homeostasis by controlling cellular cholesterol levels[J]. Nat Commun,2021,12(1):4898.
[7].Sigafoos AN,Paradise BD,Fernandez-Zapico ME. Hedgehog/GLI signaling pathway:transduction,regulation,and implications for disease[J].?Cancers (Basel),2021,13(14):3410.
[8].Li SJ,Mei QH,Zeng SY,et al. Protective effect of Sonic Hedgehog signaling pathway activation on acute myocardial infarction[J]. J Biol Regul Homeost Agents,2020,34(2):367-378.
[9].Jia B,Jiang Y,Yao Y,et al. Baicalin attenuates dexamethasone-induced apoptosis of bone marrow mesenchymal stem cells by activating the hedgehog signaling pathway[J]. Chin Med J (Engl),2023,136(15):1839-1847.
[10].Liu Y,Hou M,Wang J,et al. Shh protects the injured spinal cord in mice by promoting the proliferation and inhibiting the apoptosis of nerve cells via the Gli1-TGF-β1/ERK axis[J]. Cell Biochem Funct,2025,43(1):e70038.
[11].Li Y,Xue W,Li S,et al. Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway[J].?Biomed Pharmacother,2024,174:116625.
[12].Niu X,Li M,Gao Y,et al. DL-3-n-butylphthalide suppressed autophagy and promoted angiogenesis in rats with vascular dementia by activating the Shh/Ptch1 signaling pathway[J]. Neurosci Lett,2021,765:136266.
[13].Guo W,Yi X,Ren F,et al. Activation of SHH signaling pathway promotes vasculogenesis in post-myocardial ischemic-reperfusion injury[J]. Int J Clin Exp Pathol,2015,8(10):12464-12472.
[14].Cortese-Krott MM,Suvorava T,Leo F,et al. Red blood cell eNOS is cardioprotective in acute myocardial infarction[J]. Redox Biol,2022,54:102370.
[15].Ghaleh B,Thireau J,Cazorla O,et al. Cardioprotective effect of Sonic Hedgehog ligand in pig models of ischemia reperfusion[J]. Theranostics,2020,10(9):4006-4016.
[16].Renault MA,Roncalli J,Tongers J,et al. Sonic Hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells[J]. J Mol Cell Cardiol,2010,49(3):490-498.
[17].Wang J,Zhan H,Wang M,et al. Sonic Hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling[J]. Aging (Albany NY),2023,15(19):10540-10548.
[18].Dai RL,Zhu SY,Xia YP,et al. Sonic Hedgehog protects cortical neurons against oxidative stress[J]. Neurochem Res,2011,36(1):67-75.
[19].Zhang RY,Qiao ZY,Liu HJ,et al. Sonic Hedgehog signaling regulates hypoxia/reoxygenation-induced H9C2 myocardial cell apoptosis[J]. Exp Ther Med,2018,16(5):4193-4200.
[20].Xiao Q,Yang Y,Qin Y,et al. AMP-activated protein kinase-dependent autophagy mediated the protective effect of Sonic Hedgehog pathway on oxygen glucose deprivation-induced injury of cardiomyocytes[J]. Biochem Biophys Res Commun,2015,457(3):419-425.
[21].Zhang J,He Z,Xiong C,et al. SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation[J]. Cell Commun Signal,2024,22(1):336.
[22].Huang H,Yu H,Lin L,et al. Protective effect of Sonic Hedgehog against oxidized low?density lipoprotein?induced endothelial apoptosis :Involvement of NF-κB and Bcl-2 signaling[J]. Int J Mol Med,2020,45(6):1864-1874.
[23].Zhou X,Liu Z,Jang F,et al. Autocrine Sonic Hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10[J]. PLoS One,2012,7(8):e44121.
[24].Yao Q,Renault MA,Chapouly C,et al. Sonic Hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation[J]. Blood,2014,123(15):2429-2437.
[25].Morrow D,Cullen JP,Liu W,et al. Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A[J]. Arterioscler Thromb Vasc Biol,2009,29(7):1112-1118.
[26].Ma L,Li C,Lian S,et al. ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells[J]. Mol Cell Endocrinol,2021,519:111055.
[27].Shi H,Gao Y,Dong Z,et al. GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I/R injury[J]. Circ Res,2021,129(3):383-396.
[28].Li MR,Lu LQ,Zhang YY,et al. Sonic Hedgehog signaling facilitates pyroptosis in mouse heart following ischemia/reperfusion via enhancing the formation of CARD10-BCL10-MALT1 complex[J]. Eur J Pharmacol,2024,984:177019.
[29].Feng L,Lai QM,Zhou GM,et al. Simvastatin relieves myocardial ischemia/reperfusion injury in rats through hedgehog signaling pathway[J]. Eur Rev Med Pharmacol Sci,2020,24(11):6400-6408.
[30].Wang C,Lai Z,Tan H,et al. Impaired cardiomyocytes accelerate cardiac hypertrophy and fibrosis by delivering exosomes containing Shh/N-Shh/Gli1 in angiotensinⅡ infused mice[J]. Heliyon,2024,10(20):e39332.
[31].Li L,Gan H. Intact fibroblast growth factor 23 regulates chronic kidney disease-induced myocardial fibrosis by activating the Sonic Hedgehog signaling pathway[J]. J Am Heart Assoc,2022,11(18):e026365.
[32].Palladino M,Gatto I,Neri V,et al. Pleiotropic beneficial effects of Sonic Hedgehog gene therapy in an experimental model of peripheral limb ischemia[J]. Mol Ther,2011,19(4):658-666.
[33].Roncalli J,Renault MA,Tongers J,et al. Sonic Hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization[J]. J Am Coll Cardiol,2011,57(24):2444-2452.
[34].Wang C,Li Y,Yang X,et al. Tetramethylpyrazine and astragalosideⅣ synergistically ameliorate left ventricular remodeling and preserve cardiac function in a rat myocardial infarction model[J]. J Cardiovasc Pharmacol,2017,69(1):34-40.
[35].Riaud M,Hilairet G,Sindji L,et al. Pharmacology active microcarriers delivering HGF associated with extracellular vesicles for myocardial repair[J]. Eur J Pharm Biopharm,2021,169:268-279.
[36].Ahmed RP,Haider KH,Shujia J,et al. Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway[J]. PLoS One,2010,5(1):e8576.
[37].Munarin F,Kant RJ,Rupert CE,et al. Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts[J]. Biomaterials,2020,251:120033.
[38].Li L,Zhao J,Zhang Q,et al. Cancer cell-derived exosomes promote HCC tumorigenesis through Hedgehog pathway[J]. Front Oncol,2021,11:756205.
[39].Holla S,Stephen-Victor E,Prakhar P,et al. Mycobacteria-responsive Sonic Hedgehog signaling mediates programmed death-ligand 1- and prostaglandin E2-induced regulatory T cell expansion[J]. Sci Rep,2016,6:24193.
[40].Infante P,Malfanti A,Quaglio D,et al. Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma[J]. Cancer Lett,2021,499:220-231.

相似文献/References:

[1]王铁华,郑景辉,莫云秋.蛋白质组学在心肌梗死中的研究进展[J].心血管病学进展,2015,(5):616.[doi:10.3969/j.issn.1004-3934.2015.05.024]
 WANG Tiehua,ZHENG Jinghui,MO Yunqiu.Research Progress of Proteomics in Myocardial Infarction[J].Advances in Cardiovascular Diseases,2015,(10):616.[doi:10.3969/j.issn.1004-3934.2015.05.024]
[2]孙洋.基质金属蛋白酶与心肌梗死后心脏重构[J].心血管病学进展,2019,(8):1094.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.006]
 SUN Yang.Matrix Metalloproteinases in Cardiac Remodeling after Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(10):1094.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.006]
[3]陈丰 苏强 朱继金.高迁移率族蛋白B1在心脏炎症反应性疾病中的研究进展[J].心血管病学进展,2019,(8):1111.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.010]
 CHEN Feng,SU Qiang,ZHU Jijin.Research Progress of HMGB1 in Myocardial Inflammatory Reactivity Disease[J].Advances in Cardiovascular Diseases,2019,(10):1111.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.010]
[4]常文婧 王丽娜.Hippo通路在心脏发育、再生和疾病中的作用[J].心血管病学进展,2019,(8):1115.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.011]
 CHANG Wenjin,WANG Lina.Role of Hippo Pathway in Heart Development,Regeneration and Disease[J].Advances in Cardiovascular Diseases,2019,(10):1115.[doi:10.16806/j.cnki.issn.1004-3934.2019.08.011]
[5]王宇 周思维 张莎 吴弘.植入型心律转复除颤器在心肌梗死后心脏性猝死中的研究进展[J].心血管病学进展,2020,(1):4.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.002]
 WANG Yu,ZHOU Siwei,ZHANG Sha,et al.Implantable Cardioverter Defibrillator in Sudden Cardiac Death after Myocardial Infarction[J].Advances in Cardiovascular Diseases,2020,(10):4.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.002]
[6]邹先明 赵然尊.长链非编码RNA ANRIL与心血管疾病的研究进展[J].心血管病学进展,2020,(2):167.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.017]
 ZOU Xianming,ZHAO Ranzun.Long Non-Coding RNA ANRIL and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2020,(10):167.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.017]
[7]王茜 李晶洁.细胞学机制在调控心肌梗死后炎症反应中的研究进展[J].心血管病学进展,2020,(2):190.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.023]
 WANG QianLI Jingjie.Cytological Mechanisms in Regulation of The Post-infarction Inflammatory Response[J].Advances in Cardiovascular Diseases,2020,(10):190.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.023]
[8]黄柳,张瑞宁,田小超,等.内皮祖细胞与冠心病患者CD14CD16+单核细胞共培养后移植心肌梗死大鼠对血管密度及心肌梗死面积的影响[J].心血管病学进展,2020,(2):203.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.027]
 HUANG Liu,ZHANG Ruining,TIAN Xiaochao,et al.Effects of Co-cultured Endothelial Progenitor Cells and CD14++CD16+ Monocytes from Coronary Heart Disease Patients on Vascular Density and Myocardial Infarction Size in Transplanting Myocardial Infarction Rats[J].Advances in Cardiovascular Diseases,2020,(10):203.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.027]
[9]刘玉婷,贾锋鹏.骨膜蛋白与心血管疾病的研究进展[J].心血管病学进展,2020,(3):239.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.006]
 LIU Yuting,JIA Fengpeng.Roles of Periostin in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2020,(10):239.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.006]
[10]谢建华,赵鸿泽,刘剑雄.MicroRNA在心肌梗死后左室重塑和心力衰竭发展中的研究现状[J].心血管病学进展,2020,(3):259.[doi:10.16806 /j.cnki.issn.1004-3934.2020.03.011]
 XIE Jianhua,ZHAO Hongze,LIU Jianxiong.MicroRNA in Development of Left Ventricular Remodeling and Heart Failure after Myocardial Infarction[J].Advances in Cardiovascular Diseases,2020,(10):259.[doi:10.16806 /j.cnki.issn.1004-3934.2020.03.011]

更新日期/Last Update: 2026-01-16