[1]谢小桐 陈新云.缺血心肌细胞中的线粒体能量动力学:机制、功能与应用前景[J].心血管病学进展,2025,(9):844.[doi:10.16806/j.cnki.issn.1004-3934.2024.09.017]
 XIE Xiaotong,CHEN Xinyun.Mitochondrial Energy Dynamics in Ischemic Cardiomyocytes :Mechanisms,Functions and Clinical Perspectives[J].Advances in Cardiovascular Diseases,2025,(9):844.[doi:10.16806/j.cnki.issn.1004-3934.2024.09.017]
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缺血心肌细胞中的线粒体能量动力学:机制、功能与应用前景()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年9期
页码:
844
栏目:
综述
出版日期:
2025-09-25

文章信息/Info

Title:
Mitochondrial Energy Dynamics in Ischemic Cardiomyocytes :Mechanisms,Functions and Clinical Perspectives
作者:
谢小桐 陈新云
(成都市中西医结合医院心功能科,四川 成都 610000)
Author(s):
XIE XiaotongCHEN Xinyun
(Department of Cardiac Function,Chengdu Integrated TCM&Western Medicine Hospital,Chengdu,Sichuan 610000,China)
关键词:
心肌缺血氧化应激线粒体功能线粒体动力学
Keywords:
Myocardial ischemia Oxidative stress Mitochondrial function Mitochondrial dynamics
DOI:
10.16806/j.cnki.issn.1004-3934.2024.09.017
摘要:
线粒体是细胞能量代谢的核心,调节ATP生成、氧化还原状态和细胞死亡过程。心肌缺血显著影响线粒体功能,导致能量匮乏,抑制ATP合成,并引发氧化应激和代谢异常。心肌细胞中的线粒体不仅提供能量,还在细胞生存和死亡的调控中起关键作用。线粒体的分裂、融合和自噬是维持线粒体功能和细胞存活的关键过程,异常的线粒体动态可能加剧缺血引起的损伤。现综述心肌缺血中线粒体能量动力学的变化,探讨氧化应激在缺血心肌细胞功能障碍中的作用,并分析线粒体分裂、融合及自噬的机制,提出线粒体动力学调节可为缺血性心脏病的诊断与治疗提供新的思路和靶点的观点。
Abstract:
Mitochondria serve as the central hub for cellular energy metabolism,regulating ATP production,redox homeostasis,and cell death processes. Myocardial ischemia profoundly compromises mitochondrial function,precipitating energy deficiency,suppression of ATP synthesis,and induction of oxidative stress coupled with metabolic derangements. In cardiomyocytes,mitochondria not only provide energy but also exert pivotal roles in orchestrating cellular survival and death cascades. Mitochondrial fission,fusion,and mitophagy constitute indispensable processes that sustain mitochondrial integrity and cellular viability,whereas dysregulated dynamics may exacerbate ischemia-induced injury. This article reviews the alterations in mitochondrial energy dynamics during myocardial ischemia,examines the contributory role of oxidative stress to cardiomyocyte dysfunction in ischemic contexts,and delineates the mechanistic frameworks governing fission,fusion,and mitophagy. We propose that targeted modulation of mitochondrial dynamics presents novel diagnostic and therapeutic strategies for ischemic cardiomyopathy

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更新日期/Last Update: 2025-12-18