[1]胡晓咏 杨永鑫 张永星 李红建.IRX3在心血管疾病中的多面角色:从脂肪褐变到治疗新靶点[J].心血管病学进展,2025,(9):820.[doi:10.16806/j.cnki.issn.1004-3934.2024.09.012]
 HU Xiaoyong,YANG Yongxin,ZHANG Yongxing,et al.Multifaceted Role of IRX3 in Cardiovascular Diseases:from Fat Browning to New Therapeutic Targets[J].Advances in Cardiovascular Diseases,2025,(9):820.[doi:10.16806/j.cnki.issn.1004-3934.2024.09.012]
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IRX3在心血管疾病中的多面角色:从脂肪褐变到治疗新靶点()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年9期
页码:
820
栏目:
综述
出版日期:
2025-09-25

文章信息/Info

Title:
Multifaceted Role of IRX3 in Cardiovascular Diseases:from Fat Browning to New Therapeutic Targets
作者:
胡晓咏1 杨永鑫2 张永星1 李红建1
(1.新疆医科大学第五附属医院高血压科,新疆 乌鲁木齐 830000;2.西南交通大学附属医院 成都市第三人民医院心内科,四川 成都 610031??)
Author(s):
HU Xiaoyong1YANG Yongxin2ZHANG Yongxing1LI Hongjian1
(1.Department of Hypertension,The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China; 2. Department of Cardiology,The Affiliated Hospital of Southwest Jiaotong University,The Third People’s Hospital of Chengdu,Chengdu 610031,Sichuan,China)
关键词:
IRX3转录因子心血管疾病脂肪褐变治疗靶点
Keywords:
Iroquois homeobox 3Transcription factorsCardiovascular diseasesAdipose browningTherapeutic target
DOI:
10.16806/j.cnki.issn.1004-3934.2024.09.012
摘要:
易洛魁族同源盒3(IRX3)基因是易洛魁同源盒家族中的一员,作为转录因子之一,在胚胎发育、细胞代谢及多种生理功能的调节中发挥重要作用。研究表明,IRX3在脂肪组织中调节白色脂肪向棕色脂肪的转化,促进脂肪褐变,其与肥胖、心血管疾病也有着密切的关联。现就IRX3的分子生物学特征、在脂肪褐变和心血管疾病中的作用,以及作为治疗靶点的潜力做一简要综述。
Abstract:
Iroquois homeobox 3 (IRX3)gene is a member of the Iroquois homeobox family. As one of the transcription factors,it?plays a pivotal role in embryonic development,cellular metabolism,and the regulation of various physiological processes. Emerging evidence indicates that IRX3 regulates the conversion of white adipose tissue to brown adipose tissue,promoting adipose browning and exhibiting a strong correlation with obesity and cardiovascular diseases. This review provides a concise overview of the molecular biological characteristics of IRX3,its role in adipose browning and cardiovascular diseases,and its potential as a therapeutic target

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更新日期/Last Update: 2025-12-18