[1]青格乐 刘志强 马尔加恩·巴克依.基于非靶向代谢组学的非瓣膜性房颤患者血浆代谢特征初步分析：年龄分层的探索性研究[J].心血管病学进展,2025,(7):658.[doi:10.16806/j.cnki.issn.1004-3934.202.07.017]
　Qinggele,Liu Zhiqiang,Marjane·Barkai.Preliminary Analysis of Plasma Metabolic Characteristics in Non-Valvular Atrial Fibrillation Patients via Untargeted Metabolomics:Age-Stratified Exploratory Study[J].Advances in Cardiovascular Diseases,2025,(7):658.[doi:10.16806/j.cnki.issn.1004-3934.202.07.017]
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基于非靶向代谢组学的非瓣膜性房颤患者血浆代谢特征初步分析：年龄分层的探索性研究()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年7期
页码:
658
栏目:
论著
出版日期:
2025-07-25

文章信息/Info

Title:
Preliminary Analysis of Plasma Metabolic Characteristics in Non-Valvular Atrial Fibrillation Patients via Untargeted Metabolomics:Age-Stratified Exploratory Study
作者:
青格乐1 刘志强2 马尔加恩·巴克依1
(1.新疆医科大学第一附属医院新疆 乌鲁木齐 8300542.新疆医科大学第一附属医院综合心内科 新疆 乌鲁木齐 830054)
Author(s):
Qinggele1; Liu Zhiqiang2; Marjane·Barkai1
(1. The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China; 2. Department of Comprehensive Cardiology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
关键词:
非瓣膜性房颤血浆代谢产物年龄
Keywords:
Non-valvular atrial fibrillation; Plasma metabolites; Age
DOI:
10.16806/j.cnki.issn.1004-3934.202.07.017
摘要:
目的?/b>本研究旨在对非瓣膜性心房颤动（NVAF）患者的血浆代谢特征进行初步探索。方法 基于液相色谱-串联质谱法技术的非靶向代谢组学分析，对31例65岁的NVAF患者及健康对照组、NVAF组中再以45岁为分界进行比较分析，通过多元统计筛选差异代谢物、代谢通路分析等得出结论。结果 65岁NVAF患者筛选出显著差异代谢物（VIP＞1，P＜0.05，|log2FC|＞1），表现为光色素上调，而烟酰胺、胞嘧啶核苷二磷酸胆碱、鞘氨醇、咖啡因代谢物等显著下调，差异通路分析显示咖啡因代谢通路最为显著，二羟基十八碳鞘氨醇可作为生物标志物。对亚组的探索性分析发现，相较于45岁患者，＜45岁组特征性表现为1-（17碳一烯酰基）-溶血磷脂酰肌醇、N-乙酰-L-色氨酸等代谢物水平显著升高，N-乙酰-L-色氨酸可作为生物标志物。结论 NVAF与健康对照组相比咖啡因代谢异常可能起着关键作用。
Abstract:
Objective This study aims to preliminarily explore the plasma metabolic characteristics of patients with non-valvular atrial fibrillation (NVAF). Methods Based on the untargeted metabolomic analysis using liquid chromatography-mass spectrometry technology,a comparative analysis was conducted on 31 NVAF patients aged≤65 and healthy controls,as well as within the NVAF group,comparing those under and over 45 years old. Differential metabolites were screened using multivariate statistics,and metabolic pathway analysis was performed to draw conclusions. Results In NVAF patients aged≤65 ,significant differential metabolites (VIP＞1,P＜0.05,|log2FC|＞1) were identified,showing an upregulation of phthalocyanines and a significant downregulation of icotinamide,CDP-choline,sphingosine,and caffeine intermediate metabolites. Pathway analysis indicated that the caffeine metabolism pathway was the most significant,and D-erythro-sphinganine could serve as a biomarker. Exploratory analysis of the subgroup revealed that,compared to patients aged≥45,the＜45 age group showed significantly elevated levels of 1-(heptadecenoyl)-lysophosphatidylinositol and N-acetyl-L-tryptophan,which could act as biomarkers. Conclusion Abnormal caffeine metabolism may play a key role in NVAF group compared to healthy controls. In patients with NVAF, the group aged <45 years may have a stronger pro-fibrotic tendency and a more significant association with metabolic syndrome compared with the group aged ≥45 years

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更新日期/Last Update: 2025-09-30