[1]张江梅 俞坤武 曾秋棠.IL-1R2在心血管疾病中的研究进展[J].心血管病学进展,2025,(8):722.[doi:10.16806/j.cnki.issn.1004-3934.2025.08.012]
 ZHANG Jiangmei,YU Kunwu,ZENG Qiutang.Advances in the Role of IL-1R2 in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2025,(8):722.[doi:10.16806/j.cnki.issn.1004-3934.2025.08.012]
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IL-1R2在心血管疾病中的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年8期
页码:
722
栏目:
综述
出版日期:
2025-08-25

文章信息/Info

Title:
Advances in the Role of IL-1R2 in Cardiovascular Diseases
作者:
张江梅 俞坤武 曾秋棠
(华中科技大学 同济医学院附属协和医院心内科,湖北 武汉 430022)
Author(s):
ZHANG JiangmeiYU KunwuZENG Qiutang
(Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei China)
关键词:
白细胞介素-1受体2炎症心血管疾病发病机制预防治疗
Keywords:
Interleukin-1 receptor type 2InflammationCardiovascular diseasePathogenesisPrevention and treatment
DOI:
10.16806/j.cnki.issn.1004-3934.2025.08.012
摘要:
心血管疾病是全球主要的健康威胁之一,而炎症在其发病机制中起着关键作用。白细胞介素(IL)-1是重要的免疫和炎症因子,参与多种炎症和免疫反应过程。IL-1R2作为一种“诱饵”型受体,能够通过与IL-1特异性结合,阻断其与信号转导型受体IL-1R1的相互作用,有效减轻炎症反应。研究表明,IL-1R2可在动脉粥样硬化、心肌缺血-再灌注损伤、心肌重构等多种病理状态中发挥保护性作用,抑制内皮细胞损伤、平滑肌细胞异常增殖以及心肌细胞凋亡。现通过分析最新的基础和临床研究,探讨IL-1R2作为心血管疾病治疗新靶点的潜力,指出未来研究的方向和挑战,以期为改善心血管疾病的预防和治疗提供新的思路。
Abstract:
Cardiovascular diseases are one of the leading global health threats,and inflammation plays a critical role in their pathogenesis. IL-1 is an important immune and inflammatory mediator involved in various inflammatory and immune response processes. IL-1R2,as a "decoy" receptor,can bind specifically to IL-1,thereby blocking its interaction with the signaling receptor IL-1R1 and effectively alleviating the inflammatory response. Studies have shown that IL-1R2 exerts protective effects in various pathological conditions,such as atherosclerosis,myocardial ischemia-reperfusion injury,and myocardial remodeling,by inhibiting endothelial cell damage,smooth muscle cell abnormal proliferation,and cardiomyocyte apoptosis. This review aims to explore the potential of IL-1R2 as a novel therapeutic target in cardiovascular diseases,review recent experimental data and clinical research,and highlight future research directions and challenges,with the goal of providing new insights into the prevention and treatment of cardiovascular diseases

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更新日期/Last Update: 2025-11-11