[1]李玲娅 张俊彦 陈忠秀 贺勇.冠状动脉慢血流的研究进展[J].心血管病学进展,2025,(1):15.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.004]
　LI Lingya,ZHANG Junyan,CHEN Zhongxiu,et al.Coronary Slow Flow[J].Advances in Cardiovascular Diseases,2025,(1):15.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.004]
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冠状动脉慢血流的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年1期
页码:
15
栏目:
综述
出版日期:
2025-01-25

文章信息/Info

Title:
Coronary Slow Flow
作者:
李玲娅 张俊彦 陈忠秀 贺勇
(四川大学华西医院心脏内科,四川 成都 610041)
Author(s):
LI Lingya; ZHANG Junyan; CHEN Zhongxiu; HE Yong
(Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China)
关键词:
冠状动脉慢血流现象; 诊断标准; 发病机制; 治疗
Keywords:
Coronary slow flow; Diagnostic criteria; Pathogenesis; Treatment
DOI:
10.16806/j.cnki.issn.1004-3934.2025.01.004
摘要:
冠状动脉慢血流(CSF)是指在冠状动脉血管造影中冠状动脉管腔无显著狭窄，但冠状动脉末梢显影延迟的现象。CSF的发病机制尚未明确，治疗方案及预后存在争议。现系统综述CSF的流行病学、发病机制、诊断和治疗、与冠状动脉微血管功能障碍的关联的最新进展，以期为深入理解CSF的病理生理学提供理论基础，并为改善患者生活质量和长期预后提供思路。
Abstract:
Coronary slow flow(CSF) is taken to be indicative of delayed filling of terminal vessels of the coronary arteries in the absence of coronary stenosis during coronary angiography. The pathogenesis of CSF is not yet clear,and treatment options and prognosis are controversial. This article systematically reviews the latest progress in the epidemiology,pathogenesis,diagnosis and treatment of CSF,and its association with coronary microvascular dysfunction,in order to provide a theoretical basis for a deeper understanding of the pathophysiology of CSF and provide ideas for improving patients’ quality of life and long-term prognosis

参考文献/References:

[1] Rouzbahani M,Farajolahi S,Montazeri N,et al. Prevalence and predictors of slow coronary flow phenomenon in Kermanshah province[J]. J Cardiovasc Thorac Res,2021,13(1):37-42.

[2] Sanati H,Kiani R,Shakerian F,et al. Coronary slow flow phenomenon clinical findings and predictors[J]. Res C ardiovasc M ed,2016,5(1):e30296.

[3] Tambe AA,Demany MA,Zimmerman HA,et al. Angina pectoris and slow flow velocity of dye in coronary arteries—A new angiographic finding[J]. Am Heart J,1972,84(1):66-71.

[4] Zhu X,Shen H,Gao F,et al. Clinical profile and outcome in patients with coronary slow flow phenomenon[J]. Cardiol R es P ract,2019,2019:9168153.

[5] Tosu AR,Kalyoncuo?lu M,Biter H?,et al. Association of eosinophil-to-lymphocyte ratio with coronary slow-flow phenomenon in patients undergoing coronary angiography[J]. Arch M ed Sci?Atheroscler Dis,2022,7:e29-e35.

[6] Yu J,Yi D,Yang C,et al. Major adverse cardiovascular events and prognosis in patients with coronary slow flow[J]. Curr Prob Cardiol,2023,49(1 Pt B):102074.

[7] Saya S,Hennebry TA,Lozano P,et al. Coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias:a case report and review of literature[J]. Clin Cardiol,2008,31(8):352-355.

[8] Wozakowska-Kap?on B,Niedziela J,Krzyzak P,et al. Clinical manifestations of slow coronary flow from acute coronary syndrome to serious arrhythmias[J]. Cardiol J,2009,16(5):462-468.

[9] Gibson CM,Cannon CP,Daley WL,et al. TIMI frame count:a quantitative method of assessing coronary artery flow[J]. Circulation,1996,93(5):879-888.

[10] Beltrame JF. Defining the coronary slow flow phenomenon[J]. Circ J,2012,76(4):818-820.

[11] Beltrame JF,Cutri N,Kopetz V,et al. The role of nitric oxide in the coronary slow flow phenomenon[J]. Coron Artery Dis,2014,25(3):187-189.

[12] Erdogan D,Caliskan M,Gullu H,et al. Coronary flow reserve is impaired in patients with slow coronary flow[J]. Atherosclerosis,2007,191(1):168-174.

[13] Mosseri M,Yarom R,Gotsman MS,et al. Histologic evidence for small-vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries[J]. Circulation,1986,74(5):964-972.

[14] Pekdemir H,Cin VG,Ci?ek D,et al. Slow coronary flow may be a sign of diffuse atherosclerosis. Contribution of FFR and IVUS[J]. Acta Cardiol,2004,59(2):127-133.

[15] Yayla ?,Akbo?a MK,Gayretli Yayla K,et al. A novel marker of inflammation in patients with slow coronary flow:lymphocyte-to-monocyte ratio[J]. Biomark Med,2016,10(5):485-493.

[16] Wang C,Wu Y,Su Y,et al. Elevated levels of sIL-2R,TNF-α and hs-CRP are independent risk factors for post percutaneous coronary intervention coronary slow flow in patients with non-ST segment elevation acute coronary syndrome[J]. Int J Cardiovasc Imaging,2022,38(6):1191-1202.

[17] Y?lmaz M,Da?l? MN,Uku ?,et al. Focusing on a complete blood cell parameter:mean platelet volume levels may be a predictor of coronary slow flow[J]. Vasc H ealth Risk Manag,2017,13:255-261.

[18] Akboga MK,Canpolat U,Balci KG,et al. Increased platelet to lymphocyte ratio is related to slow coronary flow[J]. Angiology,2016,67(1):21-26.

[19] Ghaffari S,Tajlil A,Aslanabadi N,et al. Clinical and laboratory predictors of coronary slow flow in coronary angiography[J]. Perfusion,2017,32(1):13-19.

[20] Dong R,Lv Q,Gao Y,et al. Carotid artery blood velocity decreases in patients with coronary slow flow:a manifestation of systemic arteriosclerosis[J]. Echocardiography ,2019,36(12):2234-2240.

[21] Harkin KL,Loftspring E,Beaty W,et al. Visual estimates of coronary slow flow are not associated with invasive wire-based diagnoses of coronary microvascular dysfunction[J]. Circ Cardiovasc Interv,2024,17(6):e013902.

[22] Nie SP,Wang X,Geng LL,et al. Anatomic properties of coronary arteries are correlated to the corrected thrombolysis in myocardial infarction frame count in the coronary slow flow phenomenon[J]. Coron Artery Dis,2012,23(3):174-180.

[23] Kantarci M,Gündogdu F,Doganay S,et al. Arterial bending angle and wall morphology correlate with slow coronary flow:determination with multidetector CT coronary angiography[J]. Eur J Radiol,2011,77(1):111-117.

[24] Streese L,Khan AW,Deiseroth A,et al. High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene:a randomized controlled trial(EXAMIN AGE)[J]. Eur Heart J,2020,41(15):1514-1519.

[25] Fearon WF,Kobayashi Y. Invasive assessment of the coronary microvasculature:the index of microcirculatory resistance[J]. Circ Cardiovasc Interv,2017,10(12):e005361.

[26] Ong P,Camici PG,Beltrame JF,et al. International standardization of diagnostic criteria for microvascular angina[J]. Int J Cardiol,2018,250:16-20.

[27] Fineschi M,Bravi A,Gori T. The "slow coronary flow" phenomenon:evidence of preserved coronary flow reserve despite increased resting microvascular resistances[J]. Int J Cardiol,2008,127(3):358-361.

[28] Beltrame JF,Limaye SB,Wuttke RD,et al. Coronary hemodynamic and metabolic studies of the coronary slow flow phenomenon[J]. Am Heart J,2003,146(1):84-90.

[29] Mayer M,Allan T,Harkin KL,et al. Angiographic coronary slow flow is not a valid surrogate for invasively diagnosed coronary microvascular dysfunction[J]. JACC Cardiovasc Interv,2024,17(7):920-929.

[30] Dutta U,Sinha A,Demir OM,et al. Coronary slow flow is not diagnostic of microvascular dysfunction in patients with angina and unobstructed coronary arteries[J]. J Am Heart Assoc,2023,12(1):e027664.

[31] Korjian S,Gibson CM. Flowing beyond conventions:rethinking coronary slow flow in the diagnosis of?microvascular dysfunction[J]. JACC Cardiovasc Interv,2024,17(7):930-932.

[32] 中华医学会心血管病学分会. 冠状动脉微血管疾病诊断和治疗中国专家共识(2023版)[J]. 中华心血管病杂志,2024,52(5):460-492.

[33] Leone MC,Gori T,Fineschi M. The coronary slow flow phenomenon:a new cardiac " Y" syndrome?[J]. Clin H emorheol Microcirc,2008,39(1-4):185-190.

[34] Wang X,Nie SP. The coronary slow flow phenomenon:characteristics,mechanisms and implications[J]. Cardiovasc Diagn Ther,2011,1(1):37-43.

[35] Li L,Gu Y,Liu T,et al. A randomized,single-center double-blinded trial on the effects of diltiazem sustained-release capsules in patients with coronary slow flow phenomenon at 6-month follow-up[J]. PLoS One,2012,7(6):e38851.

[36] Sani HD,Eshraghi A,Nezafati MH,et al. Nicorandil versus nitroglycerin for symptomatic relief of angina in patients with slow coronary flow phenomenon:a randomized clinical trial[J]. J Cardiovasc P harmacol Ther,2015,20(4):401-406.

[37] Niu H,Wei Z,Zhang Y,et al. Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow[J]. Exp Ther M ed,2018,15(1):904-908.

[38] Guntekin U,Gumrukcuoglu HA,Gunes Y,et al. The effects of perindopril on QT duration and dispersion in patients with coronary slow flow[J]. Heart Vessels,2011,26(4):357-362.

[39] Suner A,Cetin M. The effect of trimetazidine on ventricular repolarization indexes and left ventricular diastolic function in patients with coronary slow flow[J]. Coron Artery Dis,2016,27(5):398-404.

[40] Mareai RM,Mohammed AQ,Zhang H,et al. Prognostic implication of coronary slow flow assessed by cTFC in patients with myocardial infarction with non-obstructive coronary arteries[J]. Eur J Intern Med,2023,108:74-80.

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更新日期/Last Update: 2025-02-26