[1]阿里亚·艾孜提艾力 王琪 马翔.主动脉夹层的性别差异研究进展[J].心血管病学进展,2025,(4):306.[doi:10.16806/j.cnki.issn.1004-3934.2025.04.005]
 Aliya·Aizitiaili,WANG Qi,MA Xiang.Gender Differences in Aortic Dissection[J].Advances in Cardiovascular Diseases,2025,(4):306.[doi:10.16806/j.cnki.issn.1004-3934.2025.04.005]
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主动脉夹层的性别差异研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年4期
页码:
306
栏目:
综述
出版日期:
2025-04-25

文章信息/Info

Title:
Gender Differences in Aortic Dissection
作者:
阿里亚·艾孜提艾力 王琪 马翔
(新疆医科大学第一附属医院心脏中心,新疆 乌鲁木齐 830054)
Author(s):
Aliya·AizitiailiWANG QiMA Xiang
(Heart Center,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
关键词:
主动脉夹层性别差异流行病学危险因素雌激素
Keywords:
Aortic dissectionGender differenceEpidemiologyRisk factorsEstrogen
DOI:
10.16806/j.cnki.issn.1004-3934.2025.04.005
摘要:
主动脉夹层(AD)是一种典型的性别相关性主动脉疾病。了解疾病的性别差异作为实现精准医学的必要和基本步骤,将有助于为患者做出更准确的诊疗决策。目前仍缺乏对AD性别差异的全面了解。现从AD的流行病学、危险因素和雌激素对AD的影响等方面综述AD的性别差异,为AD的精准医疗提供证据。
Abstract:
Aortic dissection (AD) is a typical gender-related aortic disease . Understanding gender differences in diseases as a necessary and basic step to achieve precision medicine will help patients make more accurate diagnosis and treatment decisions. There is still a lack of comprehensive understanding of gender differences in AD. This article reviews the gender differences in AD in terms of epidemiology,risk factors and the effects of estrogens on AD,providing evidence for the precision medicine of AD

参考文献/References:

[1]. Connelly PJ,Azizi Z,Alipour P,et al. The importance of gender to understand sex differences in cardiovascular di sease[J]. Can J Cardiol,2021,37(5):699-710.
[2]. Bossone E,Eagle KA. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes[J]. Nat Rev Cardiol,2021,18(5):331-348.
[3]. Boczar KE,Cheung K,Boodhwani M,et al. Sex differences in thoracic aortic aneurysm growth[J]. Hypertension,2019,73(1):190-196.
[4]. Carrel T,Sundt TM 3rd,von Kodolitsch Y,et al. Acute aortic dissection[J]. Lancet,2023,401(10378):773-788.
[5]. Jianhan Y,Feng L,Jiabin W,et al. Aortic dissection:global epidemiology[J].Cardiol Plus,2022,7(4):151-161.
[6]. Melvinsdottir IH,Lund SH,Agnarsson BA,et al. The incidence and mortality of acute thoracic aortic dissection: results from a whole nation study[J]. Eur J Cardiothorac Surg,2016,50(6):1111-1117.
[7]. Xia L,Li JH,Zhao K,et al. Incidence and in-hospital mortality of acute aortic dissection in China: analysis of China Health Insurance Research (CHIRA) Data 2011[J]. J Geriatr Cardiol,2015,12(5):502-506.
[8]. Dinh MM,Bein KJ,Delaney J,et al. Incidence and outcomes of aortic dissection for emergency departments in New South Wales,Australia 2017-2018:a data linkage study[J]. Emerg Med Australas,2020,32(4):599-603.
[9]. Mody PS,Wang Y,Geirsson A,et al. Trends in aortic dissection hospitalizations,interventions,and outcomes among medicare beneficiaries in the United States,2000-2011[J]. Circ Cardiovasc Qual Outcomes,2014,7(6):920-928.
[10]. McClure RS,Brogly SB,Lajkosz K,et al. Economic burden and healthcare resource use for thoracic aortic dissections and thoracic aortic aneurysms-a population-based cost-of-illness analysis[J]. J Am Heart Assoc,2020,9(11):e014981.
[11]. Harris KM,Strauss CE,Eagle KA,et al.Correlates of delayed recognition and treatment of acute type A aortic dis-section: the International Registry of Acute Aortic Dissection (IRAD)[J]. Circulation,2011,124(18):1911-1918.
[12]. Li Y,Yang N,Duan W,et al. Acute aortic dissection in China[J]. Am J Cardiol,2012,110(7):1056-1061.
[13]. Laser A,Ghosh A,Roelofs K,et al.Increased estrogen receptor alpha in experimental aortic aneurysms in females compared with males[J]. J?Surg Res,2014 ,186?(1):467-474.
[14]. Evangelista A,Isselbacher EM,Bossone E,et al. Insights from the international registry of acute aortic dissection:a 20-year experience of collaborative clinical research[J]. Circulation,2018,137(17):1846-1860.
[15]. Pacini D,di Marco L,Fortuna D,et al.?Acute aortic dissection:epidemiology and outcomes[J].?Int J Cardiol,2013,167(6):2806-2812.
[16]. Liu YJ,Wang XZ,Wang Y,et al. Correlation between sex and prognosis of acute aortic dissection in the chinese popula tion[J]. Chin Med J (Engl),2018,131(12):1430-1435.
[17]. Rylski B,Georgieva N,Beyersdorf F,et al.Gender-related differences in patients with acute aortic dissection type A[J]. J Thorac Cardiovasc Surg,2021,162(2):528-535.e1.
[18]. Chemtob RA,Hjortdal V,Ahlsson A,et al. Effects of sex on early outcome following repair of acute type A aortic dissection: results from the nordic consortium for acute type A aortic dissection (NORCAAD)[J].Aorta(Stamford),2019,7(1):7-14.
[19]. Nienaber CA,Fattori R,Mehta RH,et al. Gender-related differences in acute aortic dissection[J]. Circulation,2004,109(24):3014-3021.
[20]. Fukui T,Takanashi S. Gender differences in acute type a aortic dissection[J]. J Thorac Cardiovasc Surg,2016,151(6):1772-1773.
[21]. Howard DP,Banerjee A,Fairhead JF,et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control:10-year results from the Oxford Vascular Study[J]. Circulation,2013,127(20):2031-2037.
[22]. Pape LA,Awais M,Woznicki EM,et al. Presentation,diagnosis,and outcomes of acute aortic dissection:17-year trends from the international registry of acute aortic dissection[J]. J Am Coll Cardiol,2015,66(4):350-358.
[23]. Wang Z,Chen Z,Zhang L,et al.Status of hypertension in China:results from the China hypertension survey,2012-2015[J].Circulation,2018,137(22):2344-2356.
[24]. Benjamin EJ,Blaha MJ,Chiuve SE,et al. Heart disease and stroke Statistics-2017 update:a report from the American Heart Association[J]. Circulation,2017,135(10):e146-e603.
[25]. Ogola BO,Clark GL,Abshire CM,et al. Sex and the G protein-coupled estrogen receptor impact vascular stiffness[J]. Hypertension,2021,78(1):e1-e14.
[26]. Nucera M,Heinisch PP,Langhammer B,et al. The impact of sex and gender on aortic events in patients with Marfan syndrome[J]. Eur J Cardiothorac Surg,2022,62(5):ezac305.
[27]. Silberbach M,Roos-Hesselink JW,Andersen NH,et al. Cardiovascular health in Turner syndrome: a scientific statement from the American Heart Association[J]. Circ Genom Precis Med,2018,11(10):e000048.
[28]. Kong WKF,Bax JJ,Michelena HI,et al. Sex differences in bicuspid aortic valve disease[J]. Prog Cardiovasc Dis,2020,63(4):452-456.
[29]. Caulin-Glaser T, Watson CA, Pardi R,et al. Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression[J].J Clin Invest,1996,98(1):36-42.
[30]. Shin JA, Yoon JC, Kim M,et al. Activation of classical estrogen receptor subtypes reduces tight junction disruption of brain endothelial cells under ischemia/reperfusion injury[J].Free Radic Biol Med,2016,92:78-89.
[31]. Zahreddine R, Davezac M, Buscato M,et al.A historical view of estrogen effect on arterial endothelial healing: from animal models to medical implication[J].Atherosclerosis,2021,338:30-38.
[32]. Ivonne HS,Leopoldo R.Salt sensitivity and hypertension after menopause:role of nitric oxide and angiotensin Ⅱ[J].Am J Nephrol,2006,26(2):170-180.
[33]. Zhang B,Fan Y,Wang Y,et al. Comparison of bioelectrical body and visceral fat indices with anthropometric measures and optimal cutoffs in relation to hypertension by age and gender among Chinese adults[J]. BMC Cardiovasc Disord,2021,21(1):291.
[34]. Straface E,Vona R,Gambardella L,et al. Cell sex determines anoikis resistance in vascular smooth muscle cells[J]. FEBS Lett,2009,583(21):3448-3454.
[35]. Xia X,Zhou C,He X,et al. The relationship between estrogen-induced phenotypic transformation and proliferation of vascular smooth muscle and hypertensive intracerebral hemorrhage[J]. Ann Transl Med,2020,8(12):762.
[36]. Shuang T,Fu M,Yang G,et al. Interaction among estrogen,IGF-1,and H2S on smooth muscle cell proliferation[J]. J Endocrinol,2021,248(1):17-30.
[37]. Ailawadi G,Eliason JL,Roelofs KJ,et al.Gender differences in experimental aortic aneurysm formation[J].Arterioscler Thromb Vasc Biol, 2004,24(11):2116-2122.
[38]. Forbes TL,Lawlor DK,Derose G,et al.Gender differences in relative dilatation of abdominal aortic aneurysms[J].Ann Vasc Surg,2006,20(5):564-568.
[39]. Kurihara T,Shimizu-Hirota R,Shimoda M,et al. Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection[J].Circulation,2012,126(25): 3070-3080.
[40]. Tieu BC,Lee C,Sun H,et al. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice[J].J Clin Invest,2009,119(12):3637-3651.
[41]. Qi X,Wang F,Chun C,et al. A validated mouse model capable of recapitulating the protective effects of female sex hormones on ascending aortic aneurysms and dissections (AADs)[J].Physiol Rep,2020,8(22):e14631.

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更新日期/Last Update: 2025-05-16