[1]亢园园 罗淞元 许建忠 罗建方 卢成志.当前不同去肾神经术的特点和存在的问题[J].心血管病学进展,2024,(10):875.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.003]
 KANG yuanyuan,LUO Songyuan,XU Jianzhong,et al.The Mechanisms and Future Challenges of Different Renal Denervation Therapy[J].Advances in Cardiovascular Diseases,2024,(10):875.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.003]
点击复制

当前不同去肾神经术的特点和存在的问题()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年10期
页码:
875
栏目:
约稿
出版日期:
2024-10-25

文章信息/Info

Title:
The Mechanisms and Future Challenges of Different Renal Denervation Therapy
作者:
亢园园1 罗淞元 2 许建忠 1 罗建方 2 卢成志 3
(1.上海交通大学医学院附属瑞金医院高血压科 上海市高血压研究所,上海 200025;2. 广东省人民医院心内科,广东 510030;3. 天津市第一中心医院心内科,天津 300110)
Author(s):
KANG yuanyuan1LUO Songyuan2XU Jianzhong1LUO Jianfang2LU Chengzhi3
Department of Hypertension,Ruijin Hospital Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Hypertension,Shanghai 200025, China2. Department of Cardiology,Guangdong Provincial People’s Hospital,Guangzhou 510030,China3. Department of Cardiology,Tianjin First Central HospitalTianjin300110,China ) [
关键词:
去肾神经术射频超声高血压
Keywords:
Renal denervationRadio frequencyUltrasoundHypertension
DOI:
10.16806/j.cnki.issn.1004-3934.2024.10.003
摘要:
多个国家临床指南和专家共识均指出,经导管肾动脉消融去肾神经术(RDN)治疗高血压是除了改善生活方式和药物治疗以外第三种抗高血压治疗方法。射频、超声、乙醇等多种不同方式的RDN器械被研发并开展了系列临床研究。现将详细分析这些不同RDN消融技术的基本特性、临床研究结果及其存在的问题和争议进行仔细阐述,并对未来的发展方向进行探讨。
Abstract:
With recent robust evidence from clinical trials and real-world data showing the safety and efficacy of both ultrasound and radiofrequency-based approaches,several clinical consensus statements or hypertension guidelines for the management of arterial hypertension on the catheter-based renal denervation (RDN) had been published,confirming RDN represents another treatment option for adult patients with uncontrolled hypertension. We reviewed the results from clinical trials based on these current RDN technologies ,which including radiofrequency ablation, ultrasound ablation,alcohol injection and cryoablation,and discussed the controversy and future perspective of RDN for the treatment of hypertension

参考文献/References:

[1].Barbato E,Azizi M,Schmieder RE,et al. Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)[J]. Eur Heart J,2023,44(15):1313-1330.
[2].Kario K,Kim BK,Aoki J,et al. Renal denervation in Asia:Consensus Statement of the Asia Renal Denervation Consortium[J]. Hypertension,2020,75(3):590-602.
[3].李月平,卢成志,蒋雄京,等. 经皮去肾神经术治疗高血压中国专家科学声明[J]. 中国介入心脏病学杂志,2023,31(12):881-893.
[4].Mahfoud F,Schlaich MP,Lobo MD. Device therapy of hypertension[J].?Circ Res,2021,128(7):1080-1099.
[5].Lauder L,Azizi M,Kirtane AJ,et al. Device-based therapies for arterial hypertension[J].?Nat Rev Cardiol,2020,17(10):614-628.
[6].Townsend RR,Mahfoud F,Kandzari DE,et al,Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED):a randomised,sham-controlled,proof-of-concept trial[J]. Lancet,2017,11,390(10108):2160-2170.
[7].Mahfoud F,Kandzari DE,Kario K,et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED):a randomised,sham-controlled trial[J]. Lancet,2022,399(10333):1401-1410.
[8].B?hm M,Kario K,Kandzari DE,et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal) :a multicentre,randomised,sham-controlled trial[J]. Lancet,2020,395(10234):1444-1451.
[9].Mahfoud F,B?hm M,Schmieder R,et al. Effects of renal denervation on kidney function and long-term outcomes:3-year follow-up from the Global SYMPLICITY Registry[J]. Eur Heart J,2019,40(42):3474-3482.
[10].Wang J,Yin Y,Lu C,et al. Efficacy and safety of sympathetic mapping and ablation of renal nerves for the treatment of hypertension (SMART):6-month follow-up of a randomised,controlled trial[J]. EClinicalMedicine,2024,72:102626.
[11].Krum H,Schlaich M,Whitbourn R,et al. Catheter-based renal sympathetic denervation for resistant hypertension:a multicentre safety and proof-of-principle cohort study[J]. Lancet,2009,373(9671):1275-1281.
[12].Esler MD,Krum H,Schlaich M,et al. Renal sympathetic denervation for treatment of drug-resistant hypertension:one-year results from the Symplicity HTN-2 randomized,controlled trial[J]. Circulation,2012,126(25):2976-2982.
[13].Bakris GL,Townsend RR,Flack JM,et al. 12-month blood pressure results of catheter-based renal artery denervation for resistant hypertension:the SYMPLICITY HTN-3 trial[J]. J Am Coll Cardiol,2015,65(13):1314-1321.
[14].Singh RR,McArdle ZM,Iudica M,et al. Sustained decrease in blood pressure and reduced anatomical and functional reinnervation of renal nerves in hypertensive sheep 30 months after catheter-based renal denervation[J]. Hypertension,2019,73(3):718-727.
[15].Sharp ASP,Tunev S,Schlaich M,et al. Histological evidence supporting the durability of successful radiofrequency renal denervation in a normotensive porcine model[J]. J Hypertens,2022,40(10):2068-2075.
[16].Azizi M,Schmieder RE,Mahfoud F,et al. Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO) :a multicentre,international,single-blind,randomised,sham-controlled trial[J]. Lancet,2018, 391(10137):2335- 2345.
[17].Azizi M,Sanghvi K,Saxena M,et al. Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO):a randomised,multicentre,single-blind,sham-controlled trial[J]. Lancet,2021,397(10293):2476-2486.
[18].Rader F,Kirtane AJ,Wang Y,et al. Durability of blood pressure reduction after ultrasound renal denervation:three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial[J]. EuroIntervention,2022,18(8):e677-e685.
[19].Azizi M,Saxena M,Wang Y,et al. Endovascular ultrasound renal denervation to treat hypertension :The RADIANCE II Randomized Clinical trial[J]. JAMA,2023,329(8):651-661.
[20].Kario K,Yokoi Y,Okamura K,et al. Catheter-based ultrasound renal denervation in patients with resistant hypertension:the randomized,controlled REQUIRE trial[J]. Hypertens Res,2022,45(2):221-231.
[21].Mathiassen ON,Vase H,Bech JN,et al. Renal denervation in treatment-resistant essential hypertension. A randomized,SHAM-controlled,double-blinded 24-h blood pressure-based trial[J]. J Hypertens,2016,34(8):1639-1647.
[22].Schmieder RE,Ott C,Toennes SW,et al. Phase II randomized sham-controlled study of renal denervation for individuals with uncontrolled hypertension-WAVE IV[J]. J Hypertens,2018,36(3):680-689.
[23].Mahfoud F,Renkin J,Sievert H,et al. Alcohol-mediated renal denervation using the Peregrine System Infusion Catheter for treatment of hypertension[J]. JACC Cardiovasc Interv,2020, 13 (4):471-484.
[24].Kandzari DE,Weber MA,Pathak A,et al. Effect of alcohol-mediated renal denervation on blood pressure in the presence of antihypertensive medications:primary results from the TARGET BP I Randomized Clinical Trial[J]. Circulation,2024,149(24):1875-1884.
[25].Ji M,Chen H,Shen L,et al.Validation of a novel renal denervation system with cryoablation:a preclinical study and case series[J]. JACC Basic Transl Sci,2022,7(2):101-112.
[26].Liu Z,Shen L,Huang W,et al. Efficacy and safety of renal denervation for Chinese patients with resistant hypertension using a microirrigated catheter:study design and protocol for a prospective multicentre randomised controlled trial[J]. BMJ Open,2017,7(9):e015672.

相似文献/References:

[1]李昱熙 张震 余静 蒋雄京.去肾神经治疗高血压的临床前景和探索方向[J].心血管病学进展,2024,(10):865.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.001]
 LI YuxiZHANG ZhenYU JingJIANG Xiongjing.Future of Renal Denervation on Hypertension Therapy[J].Advances in Cardiovascular Diseases,2024,(10):865.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.001]
[2]陈晓平,左祥浩,叶涛,等.当前经导管去肾神经术治疗高血压面临的挑战[J].心血管病学进展,2024,(10):870.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.002]
 CHEN Xiaoping,ZUO Xianghao,YE Tao,et al.Current Challenges of Transcatheter Renal Denervation in the Treatment of Hypertension[J].Advances in Cardiovascular Diseases,2024,(10):870.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.002]
[3]王沛坚 陈威 董徽 马为.中国自主研发RDN器械治疗高血压临床试验数据的特色[J].心血管病学进展,2024,(10):880.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.004]
 WANG Peijian,CHEN Wei,DONG Hui,et al.Characteristics of Clinical Trial Data of RDN Devices Independently Developed in China[J].Advances in Cardiovascular Diseases,2024,(10):880.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.004]
[4]封欣妤 张冬颖 邹玉宝 冯颖青 程康.如何选择去肾神经术治疗高血压的最适宜人群[J].心血管病学进展,2024,(10):885.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.005]
 FENG Xinyu,ZHANG Dongying,ZOU Yubao,et al.How to Select the Optimal Population for Renal Denervation in the Treatment of Hypertension[J].Advances in Cardiovascular Diseases,2024,(10):885.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.005]
[5]董一飞 张毅 李燕 贾楠.经皮去肾神经术治疗高血压的临床获益:证据和争议[J].心血管病学进展,2024,(10):890.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.006]
 DONG Yifei,ZHANG Yi,LI Yan,et al.Clinical Benefit of Renal Denervation In the Treatment of Hypertension:Evidence And Controversy[J].Advances in Cardiovascular Diseases,2024,(10):890.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.006]

更新日期/Last Update: 2024-11-01