[1]李程 姜述斌.冠状动脉粥样硬化性心脏病患者冠状动脉斑块逆转的研究进展[J].心血管病学进展,2024,(9):787.[doi:10.16806/j.cnki.issn.1004-3934.2024.09.005]
 LI Cheng,JIANG Shubin.Coronary Plaque Reversal in Patients with Coronary Atherosclerotic Heart Disease[J].Advances in Cardiovascular Diseases,2024,(9):787.[doi:10.16806/j.cnki.issn.1004-3934.2024.09.005]
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冠状动脉粥样硬化性心脏病患者冠状动脉斑块逆转的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年9期
页码:
787
栏目:
综述
出版日期:
2024-09-25

文章信息/Info

Title:
Coronary Plaque Reversal in Patients with Coronary Atherosclerotic Heart Disease
作者:
李程1 姜述斌12
(1.新疆医科大学第四临床医学院,新疆 乌鲁木齐 830000;2.新疆医科大学附属中医医院CCU,新疆 乌鲁木齐 830000)
Author(s):
LI Cheng1JIANG Shubin12
(1. College of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830000,Xinjiang,China; 2. Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830000,Xinjiang,China)
关键词:
冠状动脉粥样硬化性心脏病斑块逆转低密度脂蛋白胆固醇
Keywords:
Coronary atherosclerotic heart diseasePlaque reversalLow-density lipoprotein cholesterol
DOI:
10.16806/j.cnki.issn.1004-3934.2024.09.005
摘要:
冠状动脉粥样硬化性心脏病严重威胁人类生命健康,其病理基础是冠状动脉粥样硬化斑块的形成与发展,而低密度脂蛋白胆固醇在斑块演变过程中扮演着“重要角色”,加速冠状动脉粥样硬化性心脏病的发生发展。近些年国内外相关临床研究证实,降脂治疗尤其是降胆固醇治疗不仅能延缓斑块进展,甚至在一定程度上能逆转斑块。现就冠状动脉斑块逆转的相关临床证据及治疗策略等进行概述。
Abstract:
Coronary atherosclerotic heart disease is a serious threat to human life and health,and its pathological basis is the formation and development of atherosclerotic plaque,while low-density lipoprotein cholesterol plays an “important role” in the evolution of plaque,accelerating the occurrence and development of coronary atherosclerotic heart disease. In recent years,relevant clinical studies at home and abroad have confirmed that lipid-lowering therapy,especially cholesterol-lowering therapy,can not only delay plaque progression,but even reverse plaque to a certain extent. This article reviews?the relevant clinical evidence and treatment strategies for coronary plaque reversal

参考文献/References:

[1].Nadel J,Jabbour A,Stocker R. Arterial myeloperoxidase in the detection and treatment of vulnerable atherosclerotic plaque:a new dawn for an old light[J]. Cardiovasc Res,2023,119(1):112-120.
[2].Reis ED,Li J,Fayad ZA,et al. Dramatic remodeling of advanced atherosclerotic plaques of the apolipoprotein E-deficient mouse in a novel transplantation model[J]. J Vasc Surg,2001,34(3):541-547.
[3].Friedman M,B yers SO,R osenman RH. Resolution of aortic atherosclerotic infiltration in the rabbit by phosphatide infusion [J].?Proc Soc Exp Biol Med,1957,95(3):586-588.
[4].[4]Aikawa M,Rabkin E,Okada Y,et al. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma:a potential mechanism of lesion stabilization[J]. Circulation,1998,97(24):2433-2444.
[5].[5]王增武,刘静,李建军,等. 中国血脂管理指南(2023年)[J]. 中国循环杂志,2023,38(3):237-271.
[6].[6]Grundy SM,Stone NJ,Bailey AL,et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol:A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines[J]. Circulation,2019,139(25):e1182-e1186.
[7].[7]Nicholls SJ,Tuzcu EM,Sipahi I,et al. Statins,high-density lipoprotein cholesterol,and regression of coronary atherosclerosis[J].?JAMA,2007,297(5):499-508.
[8].[8]Nissen SE,Tuzcu EM,Schoenhagen P,et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis:a randomized controlled trial[J]. JAMA,2004,291(9):1071-1080.
[9].[9]Nissen SE,Nicholls SJ,Sipahi I,et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis:the ASTEROID trial[J]. JAMA,2006,295(13):1556-1565.
[10].[10]R?ber L,Taniwaki M,Zaugg S,et al. Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4):a serial intravascular ultrasonography study[J]. Eur Heart J,2015,36(8):490-500.
[11].[11]Nicholls SJ,Ballantyne CM,Barter PJ,et al. Effect of two intensive statin regimens on progression of coronary disease[J]. N Engl J Med,2011,365(22):2078-2087.
[12].[12]Takayama T,Hiro T,Yamagishi M,et al. Effect of rosuvastatin on coronary atheroma in stable coronary artery disease:multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)[J]. Circ J,2009,73(11):2110-2117.
[13].[13]Lee CW,Kang SJ,Ahn JM,et al. Comparison of effects of atorvastatin (20 mg) versus rosuvastatin (10 mg) therapy on mild coronary atherosclerotic plaques (from the ARTMAP trial)[J]. Am J Cardiol,2012,109(12):1700-1704.
[14].[14]Zhao SP,Yu BL,Peng DQ,et al. The effect of moderate-dose versus double-dose statins on patients with acute coronary syndrome in China:results of the CHILLAS trial[J]. Atherosclerosis,2014,233(2):707-712.
[15].[15]Schmidt AF,Carter JL,Pearce LS,et al. PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease[J]. Cochrane Database Syst Rev,2020,10(10):CD011748.
[16].[16]Cannon CP,Blazing MA,Giugliano RP,et al. Ezetimibe added to statin therapy after acute coronary syndromes[J].?N Engl J Med,2015,372(25):2387-2397.
[17].[17]Sharp Collaborative Group. Study of Heart and Renal Protection (SHARP):randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease[J]. Am Heart J,2010,160(5):785-794.
[18].[18]Grassi G,del Pinto R,Agabiti Rosei C,et al. Reduction of high cholesterol levels by a preferably fixed-combination strategy as the first step in the treatment of hypertensive patients with hypercholesterolemia and high/very high cardiovascular risk:a consensus document by the Italian Society of Hypertension [J]. High Blood Press Cardiovasc Prev,2022,29(2):105-113.
[19].[19]Fruchart Gaillard C,Ouadda ABD,Ciccone L,et al. Molecular interactions of PCSK9 with an inhibitory nanobody,CAP1 and HLA-C:Functional regulation of LDLR levels[J]. Mol Metab,2023,67:101662.
[20].[20]Nicholls SJ,Puri R,Anderson T,et al. Effect of evolocumab on progression of coronary disease in statin-treated patients:the GLAGOV randomized clinical trial[J]. JAMA,2016,316(22):2373-2384.
[21].[21]韩思睿,南楠,宋现涛. 应用腔内影像评估前蛋白转化酶枯草溶菌素9抑制剂对冠状动脉斑块特征影响的研究进展[J]. 中国心血管病研究,2022,20(7):656-661.
[22].[22]Deedwania P,Murphy SA,Scheen A,et al. Efficacy and safety of PCSK9 inhibition with evolocumab in reducing cardiovascular events in patients with metabolic syndrome receiving statin therapy:secondary analysis from the FOURIER randomized clinical trial[J]. JAMA Cardiol,2021,6(2):139-147.
[23].[23]O’Donoghue ML,Giugliano RP,Wiviott SD,et al. Long-term evolocumab in patients with established atherosclerotic cardiovascular disease[J]. Circulation,2022,146(15):1109-1119.
[24].[24]Kini AS. Effect of evolocumab on coronary plaque characteristics in stable coronary artery disease:a multimodality imaging study ( the YELLOW Ⅲ study)[R]. New Orleans:American College of Cardiology(ACC)2023 Annual Scientific Sessions,2023.
[25].[25]Zhuang XD ,Liao XX ,Lin YF,et al. GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling[J]. Int J Cardiol,2023,387:131109.
[26].[26]Schwartz GG,Steg PG,Bhatt DL,et al. Clinical efficacy and safety of alirocumab after acute coronary syndrome according to achieved level of low-density lipoprotein cholesterol:a propensity score-matched analysis of the ODYSSEY OUTCOMES trial[J].?Circulation,2021,143(11):1109-1122.
[27].[27]R?ber L,Ueki Y,Otsuka T,et al. Effect of alirocumab added to high-intensity statin therapy on coronary atherosclerosis in patients with acute myocardial infarction:the PACMAN-AMI randomized clinical trial[J]. JAMA,2022,327(18):1771-1781. .
[28].[28]Nicholls SJ,Kataoka Y,Nissen SE,et al. Effect of evolocumab on coronary plaque phenotype and burden in statin-treated patients following myocardial infarction[J]. JACC Cardiovasc Imaging,2022,15(7):1308-1321.
[29].[29]Ako J,Hibi K,Tsujita K,et al. Effect of alirocumab on coronary atheroma volume in Japanese patients with acute coronary syndrome—The ODYSSEY J-IVUS trial[J].?Circ J,2019,83(10):2025-2033.
[30].[30]Huo Y,Chen B,Lian Q,et al. Tafolecimab in Chinese patients with non-familial hypercholesterolemia (CREDIT-1):a 48-week randomized ,double-blind,placebo-controlled phase 3 trial[J]. Lancet Reg Health West Pac,2023,41:100907.
[31].[31]Chai M,He Y,Zhao W,et al. Efficacy and safety of tafolecimab in Chinese patients with heterozygous familial hypercholesterolemia:a randomized,double-blind,placebo-controlled phase 3 trial (CREDIT-2)[J]. BMC Med,2023,21(1):77-77.
[32].[32]Qi L,Liu D,Qu Y,et al. Tafolecimab in Chinese patients with hypercholesterolemia (CREDIT-4):a randomized,double-blind,placebo-controlled phase 3 trial[J]. JACC Asia,2023,3(4):636-645.
[33].[33]Nambi V,Agha A. Inclisiran:a game changer in a changing game?[J]. J Am Coll Cardiol,2021,77(9):1194-1196.
[34].[34]Hardy J,Niman S,Pereira E,et al. A Critical review of the efficacy and safety of inclisiran[J]. Am J Cardiovasc Drugs,2021,21(6):629-642.
[35].[35]Fitzgerald K,Frank-Kamenetsky M,Shulga-Morskaya S,et al. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers:a randomised,single-blind,placebo-controlled,phase 1 trial[J]. Lancet,2014,383(9911):60-68.
[36].[36]Ray KK,Stoekenbroek RM,Kallend D,et al. Effect of 1 or 2 doses of inclisiran on low-density lipoprotein cholesterol levels:one-year follow-up of the ORION-1 randomized clinical trial[J]. JAMA Cardiol,2019,4(11):1067-1075.
[37].[37]Hovingh GK,Lepor NE,Kallend D,et al. Inclisiran durably lowers low-density lipoprotein cholesterol and proprotein convertase subtilisin/kexin type 9 expression in homozygous familial hypercholesterolemia :the ORION-2 pilot study[J]. Circulation,2020,141(22):1829-1831.
[38].[38]Lamb YN. Inclisiran:first approval[J]. Drugs,2021,81(3):389-395.
[39].[39]Kosmas CE,Mu?oz Estrella A,Skavdis A,et al. Inclisiran for the treatment of cardiovascular disease:a short review on the emerging data and therapeutic potential[J]. Ther Clin Risk Manag,2020,16:1031-1037.
[40].[40]Raal FJ,Kallend D,Ray KK,et al. Inclisiran for the treatment of heterozygous familial hypercholesterolemia[J]. N Engl J Med,2020,382(16):1520-1530.
[41].[41]Ray KK,Wright RS,Kallend D,et al. Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol[J]. N Engl J Med,2020,382(16):1507-1519.

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更新日期/Last Update: 2024-10-16