[1]王妤 舒俊华 干意 涂丹娜.Apelin与内皮功能障碍相关心血管疾病的研究进展及其应用展望[J].心血管病学进展,2024,(10):923.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.012]
　WANG Yu,SHU Junhua,GAN Yi,et al.Research Progress and Application Prospects of Apelin in?ardiovascular Diseases Associated with Endothelial Dysfunction[J].Advances in Cardiovascular Diseases,2024,(10):923.[doi:10.16806/j.cnki.issn.1004-3934.2024.10.012]
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Apelin与内皮功能障碍相关心血管疾病的研究进展及其应用展望()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年10期
页码:
923
栏目:
综述
出版日期:
2024-10-25

文章信息/Info

Title:
Research Progress and Application Prospects of Apelin in?ardiovascular Diseases Associated with Endothelial Dysfunction
作者:
王妤 舒俊华 干意 涂丹娜
(华中科技大学同济医学院附属湖北妇幼保健院儿内科,湖北 武汉 430070)
Author(s):
WANG Yu; SHU Junhua; GAN Yi; TU Danna?/html>
(Department of Pediatrics,Maternal and Child Health Hospital of Hubei Province,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,Hubei,China)
关键词:
内皮细胞; Apelin; 心血管疾病
Keywords:
Endothelial cell; Apelin; Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2024.10.012
摘要:
内皮细胞既是各种外界刺激和体液介质的靶细胞,又具有非常活跃的代谢功能,能分泌多种活性物质调节血管舒张，参与炎症反应以及血液凝固等过程。作为内源性多肽激素，Apelin可通过影响一氧化氮的利用、调节氧化应激、影响血小板功能、促进内皮细胞增殖迁移及血管生成等多种途径影响内皮细胞功能，维护循环系统的健康，在心血管疾病的诊疗中具备一定的前景。鉴于Apelin对内皮功能障碍的多维影响，现以Apelin为核心对其在心血管疾病的作用、机制及应用前景进行综述。
Abstract:
Endothelial cells not only serve as target cells for various external stimuli and body fluids,but also have highly active metabolic functions. They can secrete plenty of active substances to regulate vasodilation,participate in inflammation reactions,and blood coagulation processes. Apelin,an endogenous peptide hormone,impacts endothelial function via nitric oxide utilization,oxidative stress regulation,platelet function,endothelial cell proliferation andmigration,angiogenesis and so on. Apelin maintains the health of the circulatory system and holds promise in the diagnosis and treatment of cardiovascular diseases. Therefore ,this article will review the association between Apelin and endothelial dysfunction,and its role,mechanism,and prospects in cardiovascular diseases.In view of the multidimensional influence of Apelin on endothelial dysfunction,this article reviews its role, mechanism and application prospect in cardiovascular diseases with Apelin as the core.

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更新日期/Last Update: 2024-11-01