[1]鄢文婷 黄愿 王刚 李燕玲 谢萍.线粒体功能障碍与放射性心脏损伤的研究进展[J].心血管病学进展,2024,(6):557.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.018]
　YAN Wenting,HUANG Yuan,WANG Gang,et al.Mitochondrial Dysfunction and Radiation -Induced Heart Disease[J].Advances in Cardiovascular Diseases,2024,(6):557.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.018]
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线粒体功能障碍与放射性心脏损伤的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年6期
页码:
557
栏目:
综述
出版日期:
2024-06-25

文章信息/Info

Title:
Mitochondrial Dysfunction and Radiation -Induced Heart Disease
作者:
鄢文婷1 黄愿1 王刚2 李燕玲3 谢萍3
(1. 甘肃中医药大学第一临床医学院,甘肃 兰州 730000 ;2. 兰州大学第一临床医学院,甘肃 兰州 730000 ;3. 甘肃省人民医院心内科,甘肃 兰州 730000 )
Author(s):
YAN Wenting1; HUANG Yuan1; WANG Gang2; LI Yanling3; XIE Ping3
(1. The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China; 2. The First Clinical Medical College of Lanzhou University,Lanzhou 734000,Gansu,China; 3. Department of Cardiology,Gansu Provincial Hospital,Lanzhou 730000,Gansu,China)
关键词:
放射性心脏损伤; 线粒体功能; 线粒体基因组; 线粒体动力学; 线粒体自噬
Keywords:
radiation-induced heart disease;  Mitochondria function;  Mitochondrial genome;  Mitochondrial dynamics;  Mitophagy
DOI:
10.16806/j.cnki.issn.1004-3934.2024.06.018
摘要:
放射性心脏损伤（RIHD）是放射引起的一系列心血管并发症的统称，其临床主要表现有冠状动脉疾病、心肌病变、瓣膜病、心包炎、心包积液以及心律失常等。目前认为，线粒体功能障碍是RIHD的主要机制之一。心肌细胞含有大量线粒体，在辐射刺激下，线粒体基因、线粒体膜、氧化呼吸链、线粒体动力学等均发生不同程度的功能变化，可以影响心肌细胞的结局。现就RIHD过程中线粒体功能变化研究进行综述。
Abstract:
Radiation-induced heart disease (RIHD) is a collective term for a range of radiation-induced cardiovascular complications that manifest clinically as coronary artery disease,cardiomyopathy,valvular disease,pericarditis,pericardial effusions and arrhythmias etc. At present ,it is accepted that mitochondrial dysfunction is one of the main mechanisms of RIHD. Cardiomyocytes contain a large number of mitochondria,and in response to radiation stimulation,mitochondrial genes,mitochondrial membranes,oxidative respiratory chain,and mitochondrial dynamics all undergo variable degrees of functional changes that can affect cardiomyocyte outcome. In this paper,we review the research on mitochondrial dysfunction mechanisms in RIHD as follows.

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更新日期/Last Update: 2024-07-26