[1]李好 郑琦 杨琳 李双秀 孙林.嵌合抗原受体T细胞治疗在心肌纤维化中的研究进展[J].心血管病学进展,2024,(5):447.[doi:10.16806/j.cnki.issn.1004-3934.2024.05.015]
 LI Hao,ZHENG Qi,YANG LIN,et al.Chimeric Antigen Receptor T Cell Therapy in Myocardial Fibrosis[J].Advances in Cardiovascular Diseases,2024,(5):447.[doi:10.16806/j.cnki.issn.1004-3934.2024.05.015]
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嵌合抗原受体T细胞治疗在心肌纤维化中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年5期
页码:
447
栏目:
综述
出版日期:
2024-05-25

文章信息/Info

Title:
Chimeric Antigen Receptor T Cell Therapy in Myocardial Fibrosis
作者:
李好 郑琦 杨琳 李双秀 孙林
(昆明医科大学第二附属医院心血管内科,云南 昆明 650032)
Author(s):
LI HaoZHENG QiYANG LINLI ShuangxiuSUN Lin
(Department of Cardiology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China)
关键词:
嵌合抗原受体T细胞治疗细胞免疫治疗心肌纤维化
Keywords:
Chimeric antigen receptor-T cell therapyCellular immunotherapyMyocardial fibrosis
DOI:
10.16806/j.cnki.issn.1004-3934.2024.05.015
摘要:
嵌合抗原受体T(CAR-T)细胞治疗是目前细胞免疫治疗中最热门的研究领域,在肿瘤治疗中有着辉煌的成就。随着研究的深入,CAR-T细胞治疗在非肿瘤疾病中也有着重大的突破。CAR-T细胞作为过继性T细胞的一种,结合了抗体的抗原结合特性和T细胞的效应功能,能靶向消除特定的细胞。对于尚无有效治疗措施的心肌纤维化,CAR-T细胞治疗可能是一个新的治疗思路与方向。现就目前CAR-T细胞治疗在心肌纤维化中的研究进展做一综述。
Abstract:
Chimeric antigen receptor-T(CAR-T) cell therapy is currently the hottest research field in cellular immunotherapy,and has made brilliant achievements in tumor treatment. With the deepening of research,CAR-T cell therapy has also made a major breakthrough in non-tumor diseases. CAR-T cells,a type of adoptive T cell,combine the antigen-binding properties of antibodies with the effector function of T cells to target the elimination of specific cells. For myocardial fibrosis which there is no effective treatment,CAR-T cell therapy may be a new treatment idea and direction. This article reviews the current research progress of CAR-T cell therapy in myocardial fibrosis

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更新日期/Last Update: 2024-06-28