[1]刘贤玲 陈雪英 郭莹.细胞应激性衰老在心肌梗死中的作用及机制研究进展[J].心血管病学进展,2024,(5):416.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.008]
　LIU Xianling,CHEN Xueying,GUO Ying..Role and Mechanism of Cell Senescence in Myocardial Infarction[J].Advances in Cardiovascular Diseases,2024,(5):416.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.008]
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细胞应激性衰老在心肌梗死中的作用及机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年5期
页码:
416
栏目:
综述
出版日期:
2024-05-25

文章信息/Info

Title:
.Role and Mechanism of Cell Senescence in Myocardial Infarction
作者:
刘贤玲 1 陈雪英 2 郭莹 2
(1.济宁医学院临床医学院,山东 济宁 272000;2．济宁医学院附属医院心内科,山东 济宁 272000)
Author(s):
LIU Xianling1; CHEN Xueying2; GUO Ying2
?1.Clinical Medical School,Jining Medical University,Jining 272000 ,Sandong,China; 2. Department of Cardiology,Affiliated Hospital of Jining Medical University,Jining 272000,Sandong,China)
关键词:
细胞衰老; 衰老相关分泌表型; 心肌梗死; 药物治疗
Keywords:
Cell senescence; Senesence-associated secretory phenotype; Myocardial infarction;  Drug treatment
DOI:
10.16806/j.cnki.issn.1004-3934.2023.05.008
摘要:
细胞衰老被定义为不可逆的细胞周期停滞，其特征在于基因和蛋白质表达的显著改变以及衰老相关分泌表型的产生。心肌梗死后的心肌中血流需求和供应之间严重失衡可导致细胞应激性衰老的发生，其在决定心肌梗死后心脏功能转归中发挥重要作用。现主要对细胞应激性衰老在心肌梗死后维持心脏功能中的作用及机制，以及针对细胞衰老开发的药物对心肌梗死后心脏功能的影响等进行综述，为通过调节细胞衰老而改善心肌梗死的治疗提供一些新的思路。
Abstract:
Cell senescence is defined as irreversible cell cycle arrest characterized by significant alterations in gene and protein expression and the production of senesence-associated secretory phenotype. A severe imbalance between blood flow demand and supply in the myocardium after myocardial infarction can lead to the occurrence of stress cell senescence,which plays an important role in determining cardiac function outcomes after myocardial infarction. This article mainly reviews the role and mechanism of stress cell senescence in maintaining cardiac function in myocardial infarction,as well as the effect of drugs developed for cell senescence on cardiac function after myocardial infarction,so as to provide some new ideas for the treatment of myocardial infarction by regulating cellular senescence.

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更新日期/Last Update: 2024-06-28