[1]苏昕宇 顾逸淳 李芃瑾 沈浩然 毛路 陈艾东.单细胞测序在心肌梗死中的应用进展[J].心血管病学进展,2024,(6):515.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.009]
 Su Xinyu,Gu Yichun,Mao Lu,et al.Application of Single-Cell Sequencing in?yocardial Infarction[J].Advances in Cardiovascular Diseases,2024,(6):515.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.009]
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单细胞测序在心肌梗死中的应用进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年6期
页码:
515
栏目:
综述
出版日期:
2024-06-25

文章信息/Info

Title:
Application of Single-Cell Sequencing in?yocardial Infarction
作者:
苏昕宇1 顾逸淳 2 李芃瑾 2 沈浩然 2 毛路3 陈艾东24
(1.江苏大学京江学院,江苏 镇江 212013;2.南京医科大学心血管病靶向干预重点实验室,江苏 南京 211166;3.东南大学附属中大医院,江苏 南京 250012;4.杜伊斯堡-埃森大学神经生物学研究中心,德国 埃森 45127)
Author(s):
Su Xinyu 1 Gu Yichun 2Mao Lu 3Chen Aidong24
(1.Jingjiang College,Jiangsu University,Zhenjiang 212013,Jiangsu,China;2.Key Laboratory of Targeted Cardiovascular Intervention at Nanjing Medical University,Nanjing 211166,Jiangsu,China;3.Affiliated Zhongda Hospital of Southeast University,Nanjing 250012,Jiangsu,China;4.Neurobiology Research Center,University of Duisburg Essen,Essen 45127,Germany)
关键词:
单细胞测序心肌梗死异质性精准医学
Keywords:
Single cell sequencingMyocardial infarctionHeterogeneityPrecision medicine
DOI:
10.16806/j.cnki.issn.1004-3934.2024.06.009
摘要:
近年来,心血管疾病中由晚期动脉粥样硬化导致的心肌梗死(MI)成为了全球主要的死亡原因之一。在MI中由于其细胞具有高度的异质性,目前在临床阶段一直无有效的靶向治疗策略。以揭示单个细胞的基因结构和基因表达状态的单细胞测序技术正在各个领域飞速发展,并在MI的临床研究中逐渐被重视。现综述MI单细胞测序方法,并探讨MI细胞异质性、潜在的治疗靶点、心脏重构预后机制,有望为精准和靶向治疗提供依据。
Abstract:
In recent years,myocardial infarction (MI) caused by advanced atherosclerosis in cardiovascular diseases has become one of the major causes of death worldwide. Due to the high heterogeneity of its cells in MI,there has been no effective targeted therapy strategy in the clinical stage. Single cell sequencing (scRNA seq) technology,which aims to reveal the gene structure and expression status of individual cells,is rapidly developing in various fields and is gradually gaining attention in clinical research of MI. This article reviews the single cell sequencing methods of MI,and discusses the heterogeneity of MI cells,potential therapeutic targets,and the prognostic mechanism of cardiac remodeling,which is expected to provide a basis for precise and targeted treatment

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更新日期/Last Update: 2024-07-26