[1]琚敏 汪蕾 方纬.18F-NaF 正电子发射断层显像在动脉斑块显像的临床应用进展[J].心血管病学进展,2024,(2):115.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.005]
　JU MinWANG LeiFANG Wei.Clinical Application Progress of 18F-NaF PET?rterial Plaque Imaging[J].Advances in Cardiovascular Diseases,2024,(2):115.[doi:10.16806/j.cnki.issn.1004-3934.2024.02.005]
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18F-NaF 正电子发射断层显像在动脉斑块显像的临床应用进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年2期
页码:
115
栏目:
综述
出版日期:
2024-02-25

文章信息/Info

Title:
Clinical Application Progress of 18F-NaF PET?rterial Plaque Imaging
作者:
琚敏 汪蕾 方纬
(北京协和医学院 中国医学科学院阜外医院核医学科,北京,100037)
Author(s):
JU MinWANG LeiFANG Wei
?Department of Nuclear Medicine,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037, China)
关键词:
动脉斑块钙化; 18F标记氟化钠正电子发射断层显像; 冠心病
Keywords:
Arterial plaque calcification; 18F-NaF positron emission tomography; Coronary artery heart disease
DOI:
10.16806/j.cnki.issn.1004-3934.2024.02.005
摘要:
动脉粥样硬化斑块破裂是心源性猝死的主要原因，钙化的进展也是心血管病风险的一个重要预测因子，但斑块破裂的发生难以预测，钙化的进展也难以评估。近年来，快速发展的分子成像技术使得对高风险斑块的无创识别成为可能。18F标记氟化钠正电子发射断层显像是可用于无创性检测动脉高风险斑块的成像方法，不仅可识别钙化活跃的斑块，对患者进行危险分层，还可监测血管钙化的疾病进展、指导治疗干预，以及评估抗动脉粥样硬化药物的疗效，促进治疗方法的改进。现对18F标记氟化钠正电子发射断层显像的机制、识别易损斑块的能力、危险分层和预后判断的能力等方面进行综述。
Abstract:
Atherosclerotic plaque rupture is the main cause of sudden cardiac death,and the progress of calcification is also an important predictor of cardiovascular risk,but it is difficult to predict the occurrence of plaque rupture and evaluate the progress of calcification. In recent years,the rapid development of molecular imaging technology makes it possible to identify high-risk plaques non-invasively. 18F-labeled sodium fluoride positron emission tomography is a noninvasive imaging method that can be used for detection of arterial high-risk plaques,which can not only identify plaques with active calcification,stratify patients at risk,but also monitor the progression of vascular calcification,guide treatment intervention,and evaluate the efficacy of anti-atherosclerosis drugs to promote the improvement of treatment. In this paper,the mechanism of 18F-NaF PET imaging,the ability to identify vulnerable plaques,risk stratification and prognosis judgment are reviewed

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更新日期/Last Update: 2024-03-29