[1]张乐 邓嘉禾 马琳琳 宁忠平 李延飞.昼夜节律调节心律失常的机制及治疗药物的研究进展[J].心血管病学进展,2023,(12):1098.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.010]
 ZHANG Le,DENG Jiahe,MA Linlin,et al.Mechanism and Therapeutic Drugs of?ircadian Rhythm Regulating Arrhythmia[J].Advances in Cardiovascular Diseases,2023,(12):1098.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.010]
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昼夜节律调节心律失常的机制及治疗药物的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年12期
页码:
1098
栏目:
综述
出版日期:
2023-12-25

文章信息/Info

Title:
Mechanism and Therapeutic Drugs of?ircadian Rhythm Regulating Arrhythmia
作者:
张乐1 邓嘉禾 2 马琳琳 2 宁忠平 3 李延飞 34
(1.上海中医药大学研究生院,上海 201203;2.上海健康医学院医学技术学院,上海 201318;3.上海健康医学院附属周浦医院心内科,上海 201318;4.上海中医药大学,上海 201203)
Author(s):
ZHANG Le1DENG Jiahe2MA Linlin2NING Zhongping3LI Yanfei34?/html>
?1.Graduate School of Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China2.Department of Medical Technology,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China3.Department of Cardiology,The Zhoupu Hospital of Shanghai Medicine&Health Sciences University,Shanghai 201318,China4.Shanghai University of Traditional Chinese Medicine,Pudong New District,Shanghai 201203,China)
关键词:
昼夜节律生物钟心律失常抗心律失常药
Keywords:
Circadian rhythmBiological clockArrhythmiaAntiarrhythmics
DOI:
10.16806/j.cnki.issn.1004-3934.2023.12.010
摘要:
昼夜节律是一种正常生理节律,调控着机体的生理机能以适应外界环境的变化,对包括心脏在内的机体众多生理和病理过程发挥重要作用,其紊乱易导致心律失常的发生。现综述昼夜节律调节心律失常发生的分子基础及机制,归纳了伊伐布雷定、β1受体阻滞剂、莫雷西嗪、胺碘酮等治疗药物通过改变昼夜节律基因,发挥抗心律失常作用的机制,旨在为心律失常的预防、治疗及术后康复提供新的治疗思路。
Abstract:
Circadian rhythm is a normal physiological rhythm that regulates the physiological function of the body to adapt to changes in the external environment. It plays an important role in many physiological and pathological processes of the body,including the heart,and its disorder can easily lead to arrhythmia. This article reviews the molecular basis and mechanism of circadian rhythm regulation of arrhythmia,and summarizes the mechanism of antiarrhythmic effects of ivabradine,β1 receptor blocker,moricizine,amiodarone and other therapeutic drugs by changing biologi-cal clock genes,aiming to provide new ideas for the prevention,treatment and postoperative rehabilitation of arrhythmia

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更新日期/Last Update: 2024-01-19