[1]于永丽 李艳 高奋.铁死亡在血管紧张素Ⅱ诱导的心肌肥大中的作用研究进展[J].心血管病学进展,2023,(12):1116.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.014]
　YU Yongli,LI Yan,GAO Fen.Ferroptosis in Angiotensin-Induced Cardiac hypertrophy[J].Advances in Cardiovascular Diseases,2023,(12):1116.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.014]
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铁死亡在血管紧张素Ⅱ诱导的心肌肥大中的作用研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年12期
页码:
1116
栏目:
综述
出版日期:
2023-12-25

文章信息/Info

Title:
Ferroptosis in Angiotensin-Induced Cardiac hypertrophy
作者:
于永丽 李艳 高奋
?山西医科大学第二医院心内科,山西 太原 030001)
Author(s):
YU Yongli; LI Yan; GAO Fen
(Department of Cardiovascular Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)
关键词:
铁死亡;  血管紧张素Ⅱ;  心肌肥大
Keywords:
Ferroptosis; Angiontensin; Cardiac hypertrophy
DOI:
10.16806/j.cnki.issn.1004-3934.2023.12.014
摘要:
除肥厚型心肌病外，常见的心肌肥大是指心脏在长期的前后负荷压力下，为维持正常的射血功能而使心肌细胞发生的适应性改变，表现为心肌纤维增粗、需氧量增加，但长期的超负荷工作会引起心室重塑和心脏功能失代偿。血管紧张素Ⅱ（AngⅡ）是一种寡肽类激素，是肾素-血管紧张素-醛固酮系统的重要组成部分，参与心力衰竭、心肌梗死后心脏重构、高血压性心脏病等各种心脏疾病的发生发展，是导致心肌细胞肥大的根本原因，抑制AngⅡ的作用能有效延缓心室重塑。近年来随着对铁死亡研究的深入，有人提出铁死亡在AngⅡ诱导的心肌肥大起到关键作用，抑制心肌细胞铁死亡有望阻止或延缓AngⅡ致心肌肥大。现就铁死亡在AngⅡ诱导的心肌肥大中的作用进行一个简要的综述。
Abstract:
In addition to hypertrophic cardiomyopathy,joint myocardial hypertrophy is an adaptive change in cardiac myocytes to maintain normal ejection function under prolonged anterior and posterior load stress,manifested by thickening myocardial fibers and increased oxygen demand.However,lengthy overload work causes ventricular remodeling and cardiac dysfunction. AngiotensinⅡ（AngⅡ）is an oligopeptide hormone that is a critical component of the renin-angiotensin-aldosterone system and is involved in heart failure,cardiac remodeling after myocardial infarction and hypertensive heart disease. Inhibition of AngⅡ can effectively delay ventricular remodeling. In recent years,with the in-depth study of iron death,it has been proposed that it plays a crucial role in AngⅡ-induced cardiac hypertrophy,and inhibition of cardiomyocyte ferroptosis expected to prevent or delay AngⅡ-induced cardiac hypertrophy. This article briefly reviews the role of iron death in AngⅡ-induced myocardial hypertrophy. 【

参考文献/References:

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更新日期/Last Update: 2024-01-19