[1]陈杰 常静 石秋月 陈月茗 李鑫 赵宏.钠-葡萄糖共转运蛋白2抑制剂治疗冠心病患者的疗效及作用机制[J].心血管病学进展,2023,(8):704.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.008]
 CHEN Jie,CHANG Jing,SHI Qiuyue,et al.Therapeutic Effect and Mechanism of Sodium-Glucose Linked Transporter 2 Inhibitor in Patients with Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2023,(8):704.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.008]
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钠-葡萄糖共转运蛋白2抑制剂治疗冠心病患者的疗效及作用机制()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年8期
页码:
704
栏目:
综述
出版日期:
2023-08-25

文章信息/Info

Title:
Therapeutic Effect and Mechanism of Sodium-Glucose Linked Transporter 2 Inhibitor in Patients with Coronary Heart Disease
作者:
陈杰 常静 石秋月 陈月茗 李鑫 赵宏
(重庆医科大学附属第一医院心血管内科,重庆 400010)
Author(s):
CHEN JieCHANG JingSHI QiuyueCHEN YuemingLI XinZHAO Hong
(Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
关键词:
SGLT-2抑制剂冠状动脉疾病心血管效益
Keywords:
Sodium-glucose linked transporter 2 inhibitor Coronary arterial diseaseCardiovascular benefit
DOI:
10.16806/j.cnki.issn.1004-3934.2023.08.008
摘要:
钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)是近年来上市的一种新型降血糖药,主要通过减少肾脏近曲小管中葡萄糖的重吸收来降低血糖。临床上大量的研究表明,SGLT2i对心血管有额外的益处。现围绕着SGLT2i在冠心病的一级预防和二级预防、急性心肌梗死早期、合并心力衰竭的冠心病患者中的疗效及可能的作用机制进行综述。
Abstract:
The sodium-glucose linked transporter 2 inhibitor (SGLT2i),which reduces blood glucose by reducing the reabsorption of glucose in the proximal convoluted tubules of the kidney,is a new type of hypoglycemic drug which has been marketed in recent years. Numerous clinical studies have shown that SGLT2i has additional benefits of cardiovascular system. This article reviews the cardiovascular benefits and possible mechanisms of SGLT2i in patients with coronary heart disease under different disease states

参考文献/References:

[1] Heidenreich PA,Bozkurt B,Aguilar D,et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure:Executive Summary:A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines[J]. Circulation,2022,145(18):e876-e894.

[2] Cefalu WT,Leiter LA,de Bruin TWA,et al. Dapagliflozin’s effects on glycemia and cardiovascular risk factors in high-risk patients with type 2 diabetes:a 24-week,multicenter,randomized,double-blind,placebo-controlled study with a 28-week extension[J]. Diabetes Care,2015,38(7):1218-1227.

[3] Mazidi M,Rezaie P,Gao HK,et al. Effect of sodium-glucose cotransport-2 inhibitors on blood pressure in people with type 2 diabetes mellitus:a systematic review and meta-analysis of 43 randomized control trials with 22 528 patients[J]. J Am Heart Assoc,2017,6(6):e004007.

[4] Zinman B,Wanner C,Lachin JM,et al. Empagliflozin,cardiovascular outcomes,and mortality in type 2 diabetes[J]. N Engl J Med,2015,373(22):2117-2128.

[5] Zhao Y,X u L,T ian D,et al. Effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid level:a meta-analysis of randomized controlled trials[J]. Diabetes Obes Metab,2018,20(2):458- 462.

[6] Nasiri-Ansari N,D imitriadis GK,A grogiannis G,et al. Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice[J]. Cardiovasc Diabetol,2018,17(1):106.

[7] Leng W,O uyang X,L ei X,et al. The SGLT-2 inhibitor dapagliflozin has a therapeutic effect on atherosclerosis in diabetic ApoE-/- mice[J]. Mediators Inflamm,2016,2016:6305735.

[8] D’Onofrio N,Sardu C,T rotta MC,et al. Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques:effects of sodium-glucose co-transporter2 inhibitor treatment[J]. Mol Metab,2021,54:101337.

[9] Neal B,P erkovic V,M ahaffey KW,et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes[J]. N Engl J Med,2017,377(7):644-657.

[10] Wiviott SD,R az I,B onaca MP,et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes[J]. N Engl J Med,2019,380(4):347-357.

[11] Cannon CP,P ratley R,D agogo JS,et al. Cardiovascular outcomes with ertugliflozin in type 2 diabetes[J]. N Engl J Med,2020,383(15):1425-1435.

[12] Khunti K,Kosiborod M,K im DJ,et al. Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors vs other glucose-lowering drugs in 13 countries across three continents:analysis of CVD-REAL data[J]. Cardiovasc Diabetol,2021,20(1):159.

[13] Birkeland KI,J?rgensen ME,Carstensen B,et al. Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic):a multinational observational analysis[J]. Lancet Diabetes Endocrinol,2017,5(9):709-717.

[14] Tripolt NJ,Kolesnik E,Pferschy PN,et al. Impact of EMpagliflozin on cardiac function and biomarkers of heart failure in patients with acute MYocardial infarction—The EMMY trial[J]. Am Heart J,2020,221:39-47.

[15] Udell JA,J ones WS,P etrie MC,et al. Sodium glucose cotransporter-2 inhibition for acute myocardial infarction:JACC review topic of the week[J]. J Am Coll Cardiol,2022,79(20):2058-2068.

[16] Shimizu W,K ubota Y,H oshika Y,et al. Effects of empagliflozin versus placebo on cardiac sympathetic activity in acute myocardial infarction patients with type 2 diabetes mellitus:the EMBODY trial[J]. Cardiovasc Diabetol,2020,19(1):148.

[17] Fitchett D. A safety update on sodium glucose co-transporter 2 inhibitors[J]. Diabetes Obes Metab,2019,21 Suppl 2:34-42.

[18] Bhatt DL,Szarek M,Steg PG,et al. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure[J]. N Engl J Med,2021,384(2):117-128.

[19] McMurray JJV,Solomon SD,Inzucchi SE,et al. Dapagliflozin in patients with heart failure and reduced ejection fraction[J]. N Engl J Med,2019,381(21):1995-2008.

[20] Packer M,Anker SD,Butler J,et al. Cardiovascular and renal outcomes with empagliflozin in heart failure[J]. N Engl J Med,2020,383(15):1413-1424.

[21] Cunningham JW,Vaduganathan M,Claggett BL,et al. Dapagliflozin in patients recently hospitalized with heart failure and mildly reduced or preserved ejection fraction[J]. J Am Coll Cardiol,2022,80(14):1302-1310.

[22] Anker SD,Butler J,Filippatos G,et al. Empagliflozin in heart failure with a preserved ejection fraction[J]. N Engl J Med,2021,385(16):1451-1461.

[23] Jaswal JS,Keung W,Wang W,et al. Targeting fatty acid and carbohydrate oxidation—A novel therapeutic intervention in the ischemic and failing heart[J]. Biochim Biophys Acta,2011,1813(7):1333-1350.

[24] Horton JL,Davidson MT,Kurishima C,et al. The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense[J]. JCI Insight,2019,4(4):e124079.

[25] Selvaraj S,Kelly DP,Margulies KB. Implications of altered ketone metabolism and therapeutic ketosis in heart failure[J]. Circulation,2020,141(22):1800-1812.

[26] Santos-Gallego CG,Requena-Ibanez JA,San Antonio R,et al. Empagliflozin ameliorates adverse left?ventricular remodeling in nondiabetic heart failure by enhancing myocardial energetics[J]. J Am Coll Cardiol,2019,73(15):1931-1944.

[27] Verma S,Rawat S,Ho KL,et al. Empagliflozin increases cardiac energy?production?in diabetes:novel translational insights into the heart failure benefits?of?SGLT2 inhibitors[J]. JACC Basic Transl Sci,2018,3(5):575-587.

[28] Liu Y,Wu M,Xu B,et al. Empagliflozin alleviates atherosclerosis progression by inhibiting inflammation and sympathetic activity in a normoglycemic mouse model[J]. J Inflamm Res,2021,14:2277-2287.

[29] Yu YW,Que JQ,Liu S,et al. Sodium-glucose co-transporter-2 inhibitor of dapagliflozin attenuates myocardial ischemia/reperfusion injury by limiting NLRP3 inflammasome activation and modulating autophagy[J]. Front Cardiovasc Med,2021,8:768214.

[30] Li X,R?mer G,Kerindongo RP,et al. Sodium glucose co-transporter 2 inhibitors ameliorate endothelium barrier dysfunction induced by cyclic stretch through inhibition of reactive oxygen species[J]. Int J Mol Sci,2021,22(11):6044.

[31] Ma L,Zou R,Shi W,et al. SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways[J]. Theranostics,2022,12(11):5034-5050.

[32] Zou R,Shi W,Qiu J,et al. Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis[J]. Cardiovasc Diabetol,2022,21(1):106.

[33] Zhang Y,Lin X,Chu Y,et al. Dapagliflozin:a sodium-glucose cotransporter 2 inhibitor,attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGFβ1/Smad signaling[J]. Cardiovasc Diabetol,2021,20(1):121.

[34] Packer M. Molecular,cellular,and clinical evidence that sodium-glucose cotransporter 2 inhibitors act as neurohormonal antagonists when used for the treatment of chronic heart failure[J]. J Am Heart Assoc,2020,9(16):e016270.

[35] Lahnwong S,Palee S,Apaijai N,et al. Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury[J]. Cardiovasc Diabetol,2020,19(1):91.

[36] Maruyama T,Takashima H,Oguma H,et al. Canagliflozin improves erythropoiesis in diabetes patients with anemia of chronic kidney disease[J]. Diabetes Technol Ther,2019,21(12):713-720.

[37] Uthman L,Nederlof R,Eerbeek O,et al. Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts[J]. Cardiovasc Res,2019,115(10):1533-1545.

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更新日期/Last Update: 2023-09-21