[1]王振宇,张飞飞,党懿.脂蛋白a与支架内再狭窄相关性的研究进展[J].心血管病学进展,2023,(9):786.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.005]
 WANG Zhenyu,ZHANG Feifei,DANG Yi.The Correlation Between Lipoprotein (a) and In-Stent Restenosis[J].Advances in Cardiovascular Diseases,2023,(9):786.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.005]
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脂蛋白a与支架内再狭窄相关性的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年9期
页码:
786
栏目:
综述
出版日期:
2023-09-25

文章信息/Info

Title:
The Correlation Between Lipoprotein (a) and In-Stent Restenosis
作者:
王振宇1 张飞飞2 党懿2
(1.河北医科大学研究生院,河北 石家庄 050017;2.河北省人民医院心内科,河北 石家庄 050051)
Author(s):
WANG Zhenyu 1ZHANG Feifei 2DANG Yi 2
Hebei Medical University Graduate School,Shijiazhuang 050017,Hebei,China; 2. Department of Cardiology,Hebei General Hospital,Shijiazhuang 050051,Hebei,China)
关键词:
脂蛋白a支架内再狭窄冠状动脉粥样硬化性心脏病
Keywords:
Lipoprotein a In-stent restenosis Coronary atherosclerotic heart disease
DOI:
10.16806/j.cnki.issn.1004-3934.2023.09.005
摘要:
流行病学研究不断积累的证据表明,血浆中脂蛋白a [Lp(a)]水平的升高是冠状动脉粥样硬化性心脏病的独立危险因素。然而对于Lp(a)诱导支架内再狭窄的直接证据仍缺乏相关基础及临床研究,但目前研究表明Lp(a)可通过促进血栓形成、炎症反应及血管内膜增生影响支架内再狭窄的发生。现就Lp(a)的生物学特性、有关Lp(a)诱导支架内再狭窄的病理生理机制以及针对Lp(a)的相关治疗的研究进展进行综述。
Abstract:
Accumulating evidence from epidemiological studies indicate that elevated plasma concentrations of lipoprotein (a) [Lp(a)] is independent risk factors for coronary atherosclerotic heart disease. However, there is still a lack of relevant basic and clinical research on the direct evidence of Lp(a) induced in-stent restenosis. Current studies have shown that Lp(a) can affect the occurrence of in-stent restenosis by promoting thrombosis,inflammatory response and intimal hyperplasia. This article reviews the biological characteristics of Lp(a),the pathophysiological mechanisms of Lp(a) induced in-stent restenosis,and the research progress in the treatment of Lp(a)

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更新日期/Last Update: 2023-10-17